RNA-sequencing reveals transcriptional up-regulation of Trem2 in response to bexarotene treatment. (Q35662879)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26071899%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

title

RNA-sequencing reveals transcriptional up-regulation of Trem2 in response to bexarotene treatment (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26071899%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

3

1 reference

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17 February 2020

Kyong Nyon Nam

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26071899%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

Nicholas F. Fitz

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26071899%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

Radosveta Koldamova

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26071899%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

author name string

Iliya Lefterov

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26071899%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

Jonathan Schug

2

1 reference

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17 February 2020

publication date

10 June 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26071899%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

published in

Neurobiology of Disease

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26071899%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

volume

82

1 reference

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17 February 2020

page(s)

132-140

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26071899%20AND%20SRC:MED&resulttype=core&format=json

Promotion of expression of interferon-stimulated genes in U937 monocytic cells by HIV RNAs, measured using stable isotope labeling with amino acids in cell culture (SILAC).

17 February 2020

cites work

1 reference

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APOE Genotype Alters Immunoglobulin Subtypes in Knock-In Mice

12 July 2018

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TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.

12 July 2018

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TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model

12 July 2018

1 reference

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Linking Genetics of Brain Changes to Alzheimer's Disease: Sparse Whole Genome Association Scan of Regional MRI Volumes in the ADNI and AddNeuroMed Cohorts

12 July 2018

1 reference

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Il10 deficiency rebalances innate immunity to mitigate Alzheimer-like pathology

12 July 2018

1 reference

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IL-10 alters immunoproteostasis in APP mice, increasing plaque burden and worsening cognitive behavior.

12 July 2018

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Effects of n-3 FA supplementation on the release of proresolving lipid mediators by blood mononuclear cells: the OmegAD study

12 July 2018

1 reference

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IFITM-Family Proteins: The Cell's First Line of Antiviral Defense

12 July 2018

1 reference

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Alzheimer's disease is associated with altered expression of genes involved in immune response and mitochondrial processes in astrocytes

12 July 2018

1 reference

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Regulation of synaptic plasticity and cognition by SUMO in normal physiology and Alzheimer's disease

12 July 2018

1 reference

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Common variants associated with general and MMR vaccine-related febrile seizures

12 July 2018

1 reference

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What happens to microglial TREM2 in Alzheimer's disease: Immunoregulatory turned into immunopathogenic?

12 July 2018

1 reference

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Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo.

12 July 2018

1 reference

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Complement, c1q, and c1q-related molecules regulate macrophage polarization

12 July 2018

1 reference

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The interferon-induced gene Ifi27l2a is active in lung macrophages and lymphocytes after influenza A infection but deletion of Ifi27l2a in mice does not increase susceptibility to infection

12 July 2018

1 reference

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Inhibition of the CXCL12/CXCR4 chemokine axis with AMD3100, a CXCR4 small molecule inhibitor, worsens murine hepatic injury

12 July 2018

1 reference

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HDL and cognition in neurodegenerative disorders.

12 July 2018

1 reference

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Complement protein C1q promotes macrophage anti-inflammatory M2-like polarization during the clearance of atherogenic lipoproteins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640940

TYROBP in Alzheimer's disease

12 July 2018

1 reference

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The neuroprotective effect of Klotho is mediated via regulation of members of the redox system

12 July 2018

1 reference

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The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages.

12 July 2018

1 reference

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TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640940

Complement protein C1q and adiponectin stimulate Mer tyrosine kinase-dependent engulfment of apoptotic cells through a shared pathway

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640940

ATP-binding cassette transporter A1: from metabolism to neurodegeneration

12 July 2018

1 reference

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Apolipoprotein D takes center stage in the stress response of the aging and degenerative brain

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640940

Macroglia-microglia interactions via TSPO signaling regulates microglial activation in the mouse retina

12 July 2018

1 reference

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voom: Precision weights unlock linear model analysis tools for RNA-seq read counts

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640940

The retinoid X receptor agonist bexarotene relieves positive symptoms of schizophrenia: a 6-week, randomized, double-blind, placebo-controlled multicenter trial.

12 July 2018

1 reference

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TREM2 and the neuroimmunology of Alzheimer's disease

12 July 2018

1 reference

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Genome-wide approaches reveal EGR1-controlled regulatory networks associated with neurodegeneration

12 July 2018

1 reference

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Gene expression profiling by mRNA sequencing reveals increased expression of immune/inflammation-related genes in the hippocampus of individuals with schizophrenia

12 July 2018

1 reference

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The microglial sensome revealed by direct RNA sequencing

12 July 2018

1 reference

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Small, dense high-density lipoprotein-3 particles are enriched in negatively charged phospholipids: relevance to cellular cholesterol efflux, antioxidative, antithrombotic, anti-inflammatory, and antiapoptotic functionalities.

12 July 2018

1 reference

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The hypoxia-inducible transcription factor ZNF395 is controlled by IĸB kinase-signaling and activates genes involved in the innate immune response and cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640940

Irgm1-deficient mice exhibit Paneth cell abnormalities and increased susceptibility to acute intestinal inflammation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640940

Plasminogen activator inhibitor-2 polymorphism associates with recurrent coronary event risk in patients with high HDL and C-reactive protein levels

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640940

Comment on "ApoE-Directed Therapeutics Rapidly Clear -Amyloid and Reverse Deficits in AD Mouse Models"

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640940

Comment on "ApoE-Directed Therapeutics Rapidly Clear -Amyloid and Reverse Deficits in AD Mouse Models"

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640940

Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease

12 July 2018

1 reference

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From development to dysfunction: microglia and the complement cascade in CNS homeostasis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640940

Genome-wide alteration of histone H3K9 acetylation pattern in mouse offspring prenatally exposed to arsenic

12 July 2018

1 reference

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Variant of TREM2 Associated with the Risk of Alzheimer's Disease

12 July 2018

1 reference

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C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-β neurotoxicity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640940

Complement component C1q regulates macrophage expression of Mer tyrosine kinase to promote clearance of apoptotic cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640940

Molecular cloning of chicken interleukin-5 receptor α-chain and analysis of its binding specificity

12 July 2018

1 reference

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ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models

12 July 2018

1 reference

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CTRP family: linking immunity to metabolism

12 July 2018

1 reference

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Comprehensive gene expression profiling in the prefrontal cortex links immune activation and neutrophil infiltration to antinociception.

12 July 2018

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Molecular mechanisms for synchronized transcription of three complement C1q subunit genes in dendritic cells and macrophages

12 July 2018

1 reference

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Structural Basis for Fc RIIa Recognition of Human IgG and Formation of Inflammatory Signaling Complexes

12 July 2018

1 reference

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Comparative analysis of RNA-Seq alignment algorithms and the RNA-Seq unified mapper (RUM).

12 July 2018

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Controlling the response: predictive modeling of a highly central, pathogen-targeted core response module in macrophage activation

12 July 2018

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Apolipoprotein A-I deficiency increases cerebral amyloid angiopathy and cognitive deficits in APP/PS1DeltaE9 mice

12 July 2018

1 reference

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Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease

12 July 2018

1 reference

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Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice

12 July 2018

1 reference

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Interferon-inducible p200-family proteins as novel sensors of cytoplasmic DNA: role in inflammation and autoimmunity

12 July 2018

1 reference

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The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus

12 July 2018

1 reference

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PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance

12 July 2018

1 reference

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Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR.

12 July 2018

1 reference

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A C-type lectin MGL1/CD301a plays an anti-inflammatory role in murine experimental colitis

12 July 2018

1 reference

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PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale

12 July 2018

1 reference

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ApoE promotes the proteolytic degradation of Abeta

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640940

The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640940

22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640940

Intravenous immunoglobulin promotes antitumor responses by modulating macrophage polarization.

12 July 2018

1 reference

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Haematopoietic stem cell induction by somite-derived endothelial cells controlled by meox1.

25 September 2018

1 reference

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Reversal of apoE4-driven brain pathology and behavioral deficits by bexarotene.

25 September 2018

1 reference

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Transthyretin suppresses the toxicity of oligomers formed by misfolded proteins in vitro

25 September 2018

1 reference

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Effect of proinflammatory gene polymorphisms on the risk of Alzheimer's disease

25 September 2018

1 reference

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Inflammatory components in human Alzheimer's disease and after active amyloid-β42 immunization

25 September 2018

1 reference

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Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models".

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640940

Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models".

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640940

Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640940

Injury-induced type I IFN signaling regulates inflammatory responses in the central nervous system.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640940

Bexarotene as add-on to antipsychotic treatment in schizophrenia patients: a pilot open-label trial

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640940

Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640940

Differentiation of mouse embryonic stem cells into a defined neuronal lineage

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640940

Whole-blood transcriptional profiling of interferon-inducible genes identifies highly upregulated IFI27 in primary myelofibrosis

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26071899

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.NBD.2015.05.019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26071899%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26071899%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

1 reference