Role of MeCP2, DNA methylation, and HDACs in regulating synapse function (Q35680712)

9 August 2017

title

Role of MeCP2, DNA methylation, and HDACs in regulating synapse function (English)

1 reference

9 August 2017

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1

Ege T Kavalali

1 reference

9 August 2017

3

Lisa M Monteggia

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9 August 2017

Erika D Nelson

2

1 reference

9 August 2017

publication date

2 March 2011

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Journal of Neurodevelopmental Disorders

9 August 2017

published in

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9 August 2017

volume

3

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9 August 2017

issue

3

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9 August 2017

page(s)

250-256

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Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

9 August 2017

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Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons.

12 July 2018

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12 July 2018

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12 July 2018

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Histone deacetylases 1 and 2 form a developmental switch that controls excitatory synapse maturation and function

12 July 2018

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HDAC2 negatively regulates memory formation and synaptic plasticity.

12 July 2018

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Non-cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology

12 July 2018

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Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice

12 July 2018

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Deletion of Mecp2 in Sim1-expressing neurons reveals a critical role for MeCP2 in feeding behavior, aggression, and the response to stress.

12 July 2018

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MeCP2, a key contributor to neurological disease, activates and represses transcription

12 July 2018

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Activity-dependent suppression of miniature neurotransmission through the regulation of DNA methylation.

12 July 2018

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The histone deacetylase inhibitor valproic acid enhances acquisition, extinction, and reconsolidation of conditioned fear

12 July 2018

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MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number

12 July 2018

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Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation

12 July 2018

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Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear

12 July 2018

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Covalent modification of DNA regulates memory formation

12 July 2018

1 reference

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Mechanisms of disease: neurogenetics of MeCP2 deficiency

12 July 2018

1 reference

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Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome

12 July 2018

1 reference

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Postnatal loss of methyl-CpG binding protein 2 in the forebrain is sufficient to mediate behavioral aspects of Rett syndrome in mice

12 July 2018

1 reference

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Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome

12 July 2018

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Hippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261274

MECP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisions

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261274

The transcriptional repressor Mecp2 regulates terminal neuronal differentiation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261274

Model of autism: increased ratio of excitation/inhibition in key neural systems

12 July 2018

1 reference

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Signaling from synapse to nucleus: the logic behind the mechanisms

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261274

Expression of various genes is controlled by DNA methylation during mammalian development

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261274

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

12 July 2018

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Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain

12 July 2018

1 reference

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Activity-dependent synaptogenesis in the adult Mammalian cortex

12 July 2018

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Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261274

Postmortem brain abnormalities of the glutamate neurotransmitter system in autism

12 July 2018

1 reference

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Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261274

A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261274

Rett syndrome: methyl-CpG-binding protein 2 mutations and phenotype-genotype correlations

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261274

Functional consequences of Rett syndrome mutations on human MeCP2.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261274

Dendritic anomalies in disorders associated with mental retardation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261274

Maintenance-type DNA methyltransferase is highly expressed in post-mitotic neurons and localized in the cytoplasmic compartment

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261274

Rett syndrome and beyond: recurrent spontaneous and familial MECP2 mutations at CpG hotspots

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261274

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261274

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261274

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261274

A progressive syndrome of autism, dementia, ataxia, and loss of purposeful hand use in girls: Rett's syndrome: report of 35 cases

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261274

Systemic or intrahippocampal delivery of histone deacetylase inhibitors facilitates fear extinction

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261274

Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261274

MeCP2-dependent transcriptional repression regulates excitatory neurotransmission

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261274

Mutations found within exon 1 of MECP2 in Danish patients with Rett syndrome

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261274

Increased dendritic complexity and axonal length in cultured mouse cortical neurons overexpressing methyl-CpG-binding protein MeCP2.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261274

Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261274

Mild overexpression of MeCP2 causes a progressive neurological disorder in mice.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261274

The metabotropic glutamate receptor 8 gene at 7q31: partial duplication and possible association with autism

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261274

MECP2 mutations account for most cases of typical forms of Rett syndrome.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261274

Rett syndrome: analysis of MECP2 and clinical characterization of 31 patients.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261274

The methyl-CpG binding protein MeCP2 is essential for embryonic development in the mouse.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261274

DNA mismatch repair and DNA methylation in adult brain neurons.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261274

Expression of DNA methyltransferase gene in mature and immature neurons as well as proliferating cells in mice

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261274

Prevalence of fragile X syndrome

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21484197

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Effects of Rett syndrome mutations of the methyl-CpG binding domain of the transcriptional repressor MeCP2 on selectivity for association with methylated DNA

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21484197

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S11689-011-9078-3

1 reference

9 August 2017

1 reference

9 August 2017

1 reference