S1P(1) receptor modulation with cyclical recovery from lymphopenia ameliorates mouse model of multiple sclerosis (Q35688505)

9 August 2017

title

S1P(1) receptor modulation with cyclical recovery from lymphopenia ameliorates mouse model of multiple sclerosis (English)

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9 August 2017

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1 reference

Pedro J Gonzalez-Cabrera

1

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9 August 2017

Stuart M Cahalan

2

1 reference

9 August 2017

Nhan Nguyen

3

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9 August 2017

Gor Sarkisyan

4

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9 August 2017

Nora B Leaf

5

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9 August 2017

Michael D Cameron

6

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9 August 2017

Tomoyuki Kago

7

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9 August 2017

Hugh Rosen

8

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9 August 2017

publication date

26 October 2011

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9 August 2017

published in

Molecular Pharmacology

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9 August 2017

volume

81

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9 August 2017

issue

2

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9 August 2017

page(s)

166-174

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Actions of a picomolar short-acting S1P₁ agonist in S1P₁-eGFP knock-in mice

9 August 2017

cites work

1 reference

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FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

12 July 2018

1 reference

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Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

12 July 2018

1 reference

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Cellular localization of sphingosine-1-phosphate receptor 1 expression in the human central nervous system

12 July 2018

1 reference

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Targeting sphingosine 1-phosphate (S1P) levels and S1P receptor functions for therapeutic immune interventions

12 July 2018

1 reference

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AUY954, a selective S1P(1) modulator, prevents experimental autoimmune neuritis

12 July 2018

1 reference

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B lymphocytes exit lymph nodes through cortical lymphatic sinusoids by a mechanism independent of sphingosine-1-phosphate-mediated chemotaxis.

12 July 2018

1 reference

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12 July 2018

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Immunohistochemical detection of sphingosine-1-phosphate receptor 1 in vascular and lymphatic endothelial cells

12 July 2018

1 reference

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Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions

12 July 2018

1 reference

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FTY720 modulates human oligodendrocyte progenitor process extension and survival.

12 July 2018

1 reference

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Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: consequences for mode of action in multiple sclerosis

12 July 2018

1 reference

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Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics

12 July 2018

1 reference

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Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis

12 July 2018

1 reference

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Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension

12 July 2018

1 reference

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Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263953

Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin.

12 July 2018

1 reference

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Engagement of S1P₁-degradative mechanisms leads to vascular leak in mice

12 July 2018

1 reference

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Differential responses of human microglia and blood-derived myeloid cells to FTY720.

25 September 2018

1 reference

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Reconstitution of circulating lymphocyte counts in FTY720-treated MS patients

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263953

FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263953

Phosphorylated FTY720 promotes astrocyte migration through sphingosine-1-phosphate receptors

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263953

Essential roles of sphingosine 1-phosphate/S1P1 receptor axis in the migration of neural stem cells toward a site of spinal cord injury.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263953

Sphingosine-1-phosphate via activation of a G-protein-coupled receptor(s) enhances the excitability of rat sensory neurons.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263953

Sphingosine-1-phosphate agonists increase macrophage homing, lymphocyte contacts, and endothelial junctional complex formation in murine lymph nodes

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263953

Constitutive expression of the S1P1 receptor in adult tissues.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263953

The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263953

Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263953

Sphingosine-1-phosphate receptor agonism impairs the efficiency of the local immune response by altering trafficking of naive and antigen-activated CD4+ T cells

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263953

Assessment of the role of sphingosine 1-phosphate and its receptors in high-density lipoprotein-induced stimulation of astroglial cell function

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263953

Experimental autoimmune encephalomyelitis in the mouse

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22031473

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Analysis of the mode of action of a novel immunosuppressant FTY720 in mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22031473

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1124/MOL.111.076109

1 reference

9 August 2017

1 reference

9 August 2017

1 reference