The TM2 6' position of GABA(A) receptors mediates alcohol inhibition (Q35688528)

9 August 2017

title

The TM2 6' position of GABA(A) receptors mediates alcohol inhibition (English)

1 reference

9 August 2017

W David Johnson

1

1 reference

9 August 2017

Rebecca J Howard

series ordinal

2

1 reference

9 August 2017

James R Trudell

series ordinal

3

1 reference

9 August 2017

R Adron Harris

series ordinal

4

1 reference

9 August 2017

language of work or name

English

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publication date

9 November 2011

1 reference

Journal of Pharmacology and Experimental Therapeutics

9 August 2017

published in

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9 August 2017

volume

340

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9 August 2017

issue

2

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9 August 2017

page(s)

445-456

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Structural basis for alcohol modulation of a pentameric ligand-gated ion channel

9 August 2017

cites work

1 reference

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12 July 2018

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Crystal Structures of a Cysteine-modified Mutant in Loop D of Acetylcholine-binding Protein

12 July 2018

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12 July 2018

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A transmembrane amino acid in the GABAA receptor β2 subunit critical for the actions of alcohols and anesthetics

12 July 2018

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12 July 2018

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Loop 2 structure in glycine and GABA(A) receptors plays a key role in determining ethanol sensitivity

12 July 2018

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Ethanol's molecular targets

12 July 2018

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The role of GABA(A) receptors in the development of alcoholism

12 July 2018

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GABA(A) receptors and alcohol

12 July 2018

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12 July 2018

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Closed-state cross-linking of adjacent beta1 subunits in alpha1beta1 GABAa receptors via introduced 6' cysteines

12 July 2018

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Channel opening by anesthetics and GABA induces similar changes in the GABAA receptor M2 segment

12 July 2018

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12 July 2018

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12 July 2018

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gamma-Aminobutyric acid A receptor subunit mutant mice: new perspectives on alcohol actions

12 July 2018

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Zinc-mediated inhibition of GABA(A) receptors: discrete binding sites underlie subtype specificity

12 July 2018

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Comparative surface accessibility of a pore-lining threonine residue (T6') in the glycine and GABA(A) receptors

12 July 2018

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Unique assignment of inter-subunit association in GABA(A) alpha 1 beta 3 gamma 2 receptors determined by molecular modeling

12 July 2018

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Anxiety over GABA(A) receptor structure relieved by AChBP.

12 July 2018

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GABA(A) receptor modulation of the rewarding and aversive effects of ethanol

12 July 2018

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Tryptophan scanning mutagenesis in TM2 of the GABA(A) receptor alpha subunit: effects on channel gating and regulation by ethanol

12 July 2018

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Specific binding sites for alcohols and anesthetics on ligand-gated ion channels

12 July 2018

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Anesthesia sensitivity in mice that lack the beta3 subunit of the gamma-aminobutyric acid type A receptor

12 July 2018

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Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.

12 July 2018

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Identification of channel-lining residues in the M2 membrane-spanning segment of the GABA(A) receptor alpha1 subunit

12 July 2018

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Anaesthetic potencies of primary alkanols: implications for the molecular dimensions of the anaesthetic site

12 July 2018

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Genetic manipulation of ion channels: a new approach to structure and mechanism

12 July 2018

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Neurosteroids allosterically modulate binding of the anesthetic etomidate to gamma-aminobutyric acid type A receptors

12 July 2018

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Molecular modeling and mutagenesis reveals a tetradentate binding site for Zn2+ in GABA(A) alphabeta receptors and provides a structural basis for the modulating effect of the gamma subunit

25 September 2018

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Evidence that ethanol acts on a target in Loop 2 of the extracellular domain of alpha1 glycine receptors

25 September 2018

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Knockin mice with ethanol-insensitive alpha1-containing gamma-aminobutyric acid type A receptors display selective alterations in behavioral responses to ethanol

25 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263960

Effect of chronic administration of ethanol on GABAA receptor assemblies derived from alpha2-, alpha3-, beta2- and gamma2-subunits in the rat cerebral cortex

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263960

Sites of excitatory and inhibitory actions of alcohols on neuronal alpha2beta4 nicotinic acetylcholine receptors.

25 September 2018

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Protein mobility and GABA-induced conformational changes in GABA(A) receptor pore-lining M2 segment

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263960

Substituted-cysteine accessibility method

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22072732

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1124/JPET.111.188037

1 reference

9 August 2017

1 reference

9 August 2017

1 reference