Channel opening by anesthetics and GABA induces similar changes in the GABAA receptor M2 segment (Q24683541)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17293408%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

title

Channel opening by anesthetics and GABA induces similar changes in the GABAA receptor M2 segment (English)

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25 December 2019

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4

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25 December 2019

author name string

Ayelet Rosen

series ordinal

1

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25 December 2019

Moez Bali

series ordinal

2

1 reference

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25 December 2019

Jeffrey Horenstein

series ordinal

3

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25 December 2019

language of work or name

English

0 references

publication date

9 February 2007

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25 December 2019

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25 December 2019

volume

92

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25 December 2019

issue

9

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25 December 2019

page(s)

3130-3139

1 reference

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Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

25 December 2019

cites work

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Refined structure of the nicotinic acetylcholine receptor at 4A resolution

7 April 2017

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Methionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anesthetics

7 April 2017

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Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptor

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Comparative surface accessibility of a pore-lining threonine residue (T6') in the glycine and GABA(A) receptors

7 April 2017

1 reference

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Common determinants of single channel conductance within the large cytoplasmic loop of 5-hydroxytryptamine type 3 and alpha4beta2 nicotinic acetylcholine receptors.

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Tandem subunits effectively constrain GABAA receptor stoichiometry and recapitulate receptor kinetics but are insensitive to GABAA receptor-associated protein

28 September 2017

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GABAA receptor structure-function studies: a reexamination in light of new acetylcholine receptor structures

28 September 2017

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28 September 2017

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Minimal structural rearrangement of the cytoplasmic pore during activation of the 5-HT3A receptor

28 September 2017

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Homologous sites of GABA(A) receptor alpha(1), beta(3) and gamma(2) subunits are important for assembly.

28 September 2017

1 reference

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Subunit composition, distribution and function of GABA(A) receptor subtypes

28 September 2017

1 reference

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Structure of the transition state of gating in the acetylcholine receptor channel pore: a phi-value analysis.

28 September 2017

1 reference

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Evidence for a common binding cavity for three general anesthetics within the GABAA receptor.

28 September 2017

1 reference

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Mapping the conformational wave of acetylcholine receptor channel gating

28 September 2017

1 reference

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Which molecular targets are most relevant to general anaesthesia?

28 September 2017

1 reference

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The diversity of GABAA receptors. Pharmacological and electrophysiological properties of GABAA channel subtypes

28 September 2017

1 reference

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Modulation of a recombinant invertebrate gamma-aminobutyric acid receptor-chloride channel complex by isoflurane: effects of a point mutation in the M2 domain

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

Stoichiometry and assembly of a recombinant GABAA receptor subtype.

28 September 2017

1 reference

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A general method for determining helix packing in membrane proteins in situ: helices I and II are close to helix VII in the lactose permease of Escherichia coli

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

Endogenous subunits can cause ambiguities in the pharmacology of exogenous gamma-aminobutyric acidA receptors expressed in human embryonic kidney 293 cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

Identification of channel-lining residues in the M2 membrane-spanning segment of the GABA(A) receptor alpha1 subunit

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed events

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

Interaction of picrotoxin with GABAA receptor channel-lining residues probed in cysteine mutants.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

Chloride Channel Expression with the Tandem Construct of α6-β2 GABAA Receptor Subunit Requires a Monomeric Subunit of α6 or γ2

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

Genetic manipulation of ion channels: a new approach to structure and mechanism

28 September 2017

1 reference

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The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurones

28 September 2017

1 reference

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Thermal motions of surface alpha-helices in the D-galactose chemosensory receptor. Detection by disulfide trapping

28 September 2017

1 reference

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Acetylcholine receptor channel structure probed in cysteine-substitution mutants.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

Endogenous [3H]flunitrazepam binding in human embryonic kidney cell line 293.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

Loose protein packing around the extracellular half of the GABA(A) receptor beta1 subunit M2 channel-lining segment

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

Evidence for a centrally located gate in the pore of a serotonin-gated ion channel.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

The general anesthetic propofol slows deactivation and desensitization of GABA(A) receptors.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

The location of the gate in the acetylcholine receptor channel

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

GABAA receptor needs two homologous domains of the beta-subunit for activation by GABA but not by pentobarbital.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

Catalytic oxidation of sulfhydryl groups by o-phenanthroline copper complex.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

Stoichiometry of a pore mutation that abolishes picrotoxin-mediated antagonism of the GABAA receptor.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

Defining the propofol binding site location on the GABAA receptor

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

The GABAA receptor alpha 1 subunit Pro174-Asp191 segment is involved in GABA binding and channel gating

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

The fourth transmembrane segment forms the interface of the dopamine D2 receptor homodimer.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

Structural evidence that propofol stabilizes different GABA(A) receptor states at potentiating and activating concentrations.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

Dual-function vector for protein expression in both mammalian cells and Xenopus laevis oocytes.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

Evidence for distinct conformations of the two alpha 1 subunits in diazepam-bound GABA(A) receptors

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

Subunit arrangement of gamma-aminobutyric acid type A receptors

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

Protein mobility and GABA-induced conformational changes in GABA(A) receptor pore-lining M2 segment

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

The effects of a point mutation of the beta2 subunit of GABA(A) receptor on direct and modulatory actions of general anesthetics.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

A single hydrophobic residue confers barbiturate sensitivity to gamma-aminobutyric acid type C receptor.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

Double-edged swords: volatile anesthetics both enhance and inhibit ligand-gated ion channels

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the alpha subunit.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852347

Single channel currents activated by gamma-aminobutyric acid, muscimol, and (-)-pentobarbital in cultured mouse spinal neurons

28 November 2018

1 reference

12 December 2020

Human low density lipoprotein receptor expressed in Xenopus oocytes. Conserved signals for O-linked glycosylation and receptor-mediated endocytosis

1 reference

12 December 2020

Location of a threonine residue in the α -subunit M2 transmembrane segment that determines the ion flow through the acetylcholine receptor channel

1 reference

12 December 2020

Asymmetry of the rat acetylcholine receptor subunits in the narrow region of the pore

1 reference

12 December 2020

Location of a high affinity Zn2+ binding site in the channel of alpha1beta1 gamma-aminobutyric acidA receptors

1 reference

12 December 2020

10.1529/BIOPHYSJ.106.094490

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17293408%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17293408%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

PubMed publication ID

17293408

1 reference