BRAFV600E Co-opts a Conserved MHC Class I Internalization Pathway to Diminish Antigen Presentation and CD8+ T-cell Recognition of Melanoma (Q35688821)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25795007%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

title

BRAFV600E Co-opts a Conserved MHC Class I Internalization Pathway to Diminish Antigen Presentation and CD8+ T-cell Recognition of Melanoma (English)

1 reference

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3 March 2020

3

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14

Patrick Hwu

1 reference

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3 March 2020

11

Chantale Bernatchez

1 reference

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3 March 2020

13

Michael A Davies

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3 March 2020

4

Amjad Talukder

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3 March 2020

5

Jahan S Khalili

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3 March 2020

6

Tania Rodriguez-Cruz

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3 March 2020

8

Mayra Whittington

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3 March 2020

9

Wanleng Deng

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3 March 2020

15

Gregory Lizée

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3 March 2020

author name string

Sherille D Bradley

1

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3 March 2020

Zeming Chen

2

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3 March 2020

Shujuan Liu

7

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3 March 2020

Fenge Li

10

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3 March 2020

Laszlo G Radvanyi

12

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3 March 2020

language of work or name

1 reference

20 March 2015

1 reference

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Cancer Immunology Research

3 March 2020

published in

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3 March 2020

volume

3

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3 March 2020

issue

6

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3 March 2020

page(s)

602-609

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The MAPK pathway is a predominant regulator of HLA-A expression in esophageal and gastric cancer

3 March 2020

cites work

1 reference

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Adaptor protein 1 promotes cross-presentation through the same tyrosine signal in major histocompatibility complex class I as that targeted by HIV-1.

12 July 2018

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Vemurafenib enhances MHC induction in BRAF(V600E) homozygous melanoma cells

12 July 2018

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Host immunity contributes to the anti-melanoma activity of BRAF inhibitors

12 July 2018

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BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma.

12 July 2018

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BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice

12 July 2018

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Expression of MHC Class I on breast cancer cells correlates inversely with HER2 expression

12 July 2018

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Endogenous viral antigen processing generates peptide-specific MHC class I cell-surface clusters

12 July 2018

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Oncogenic BRAF(V600E) promotes stromal cell-mediated immunosuppression via induction of interleukin-1 in melanoma

12 July 2018

1 reference

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Cross-presentation by dendritic cells

12 July 2018

1 reference

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Natural splice variant of MHC class I cytoplasmic tail enhances dendritic cell-induced CD8+ T-cell responses and boosts anti-tumor immunity

12 July 2018

1 reference

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Hallmarks of Cancer: The Next Generation

12 July 2018

1 reference

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Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4457616

MHC class I endosomal and lysosomal trafficking coincides with exogenous antigen loading in dendritic cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4457616

Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3

12 July 2018

1 reference

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Gene transfer of tumor-reactive TCR confers both high avidity and tumor reactivity to nonreactive peripheral blood mononuclear cells and tumor-infiltrating lymphocytes

12 July 2018

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The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells

12 July 2018

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Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation

12 July 2018

1 reference

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Viral interference with antigen presentation

12 July 2018

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Natural selection of tumor variants in the generation of "tumor escape" phenotypes

12 July 2018

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Phosphorylation of class I MHC molecules in the absence of phorbol esters is an intracellular event and may be characteristic of trafficking molecules

12 July 2018

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Recycling MHC class I molecules and endosomal peptide loading

12 July 2018

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Spontaneous internalization of Class I major histocompatibility complex molecules in T lymphoid cells

12 July 2018

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Constitutive endocytosis of HLA class I antigens requires a specific portion of the intracytoplasmic tail that shares structural features with other endocytosed molecules

12 July 2018

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Forging a link between oncogenic signaling and immunosuppression in melanoma

12 July 2018

1 reference

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Selective BRAF inhibitors induce marked T-cell infiltration into human metastatic melanoma

25 September 2018

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Misfolding of major histocompatibility complex class I molecules in activated T cells allows cis-interactions with receptors and signaling molecules and is associated with tyrosine phosphorylation

25 September 2018

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25 September 2018

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Human and murine class I MHC antigens share conserved serine 335, the site of HLA phosphorylation in vivo

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25795007

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Post-transcriptional downregulation of MHC class I expression in oncogene-transformed cells is reverted by IFN-gamma and TNF-alpha

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25795007

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/2326-6066.CIR-15-0030

1 reference

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3 March 2020

1 reference

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3 March 2020

PubMed publication ID

25795007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25795007%20AND%20SRC:MED&resulttype=core&format=json