Mechanisms of apoptosis in the heart (Q35697472)

9 August 2017

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title

Mechanisms of apoptosis in the heart (English)

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9 August 2017

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Asa B Gustafsson

1

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PubMed ID

15031632

9 August 2017

Roberta A Gottlieb

series ordinal

2

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9 August 2017

1 November 2003

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Journal of Clinical Immunology

9 August 2017

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9 August 2017

23

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9 August 2017

6

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9 August 2017

447-459

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https://scigraph.springernature.com/pub.10.1023/b:joci.0000010421.56035.60

9 August 2017

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cites work

MAPK superfamily plays an important role in daunomycin-induced apoptosis of cardiac myocytes

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12 December 2020

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

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12 December 2020

beta-Adrenergic pathway induces apoptosis through calcineurin activation in cardiac myocytes

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12 December 2020

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

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12 December 2020

BCL-2 family: regulators of cell death

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12 December 2020

Inducible expression of BNIP3 provokes mitochondrial defects and hypoxia-mediated cell death of ventricular myocytes.

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12 December 2020

Inhibition of death receptor signals by cellular FLIP

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12 December 2020

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

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12 December 2020

Stimulation of c-Jun kinase and mitogen-activated protein kinase by ischemia and reperfusion in the perfused rat heart

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12 December 2020

Apoptosis, oncosis, and necrosis. An overview of cell death

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12 December 2020

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

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12 December 2020

Attenuation of postischemic reperfusion injury is related to prevention of [Ca2+]m overload in rat hearts

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12 December 2020

Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure

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12 December 2020

Mitochondrial reactive oxygen species in cell death signaling

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12 December 2020

FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

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12 December 2020

Calpain activity alters in rat myocardial subfractions after ischemia or reperfusion

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12 December 2020

Calpain inhibitor-1 reduces infarct size and DNA fragmentation of myocardium in ischemic/reperfused rat heart

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12 December 2020

Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia

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12 December 2020

Mitochondria as the central control point of apoptosis

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12 December 2020

The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

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12 December 2020

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

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12 December 2020

Randomised investigation of effects of pentoxifylline on left-ventricular performance in idiopathic dilated cardiomyopathy.

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12 December 2020

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

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12 December 2020

Conversion of Bcl-2 to a Bax-like death effector by caspases

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12 December 2020

Hypoxia induces the expression of the pro-apoptotic gene BNIP3

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12 December 2020

Direct activation of mitochondrial apoptosis machinery by c-Jun N-terminal kinase in adult cardiac myocytes

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12 December 2020

Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death

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12 December 2020

The cardiac Fas (APO-1/CD95) Receptor/Fas ligand system : relation to diastolic wall stress in volume-overload hypertrophy in vivo and activation of the transcription factor AP-1 in cardiac myocytes

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12 December 2020

Overexpression of MnSOD protects against myocardial ischemia/reperfusion injury in transgenic mice.

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12 December 2020

Decreased expression of high-molecular-weight calmodulin-binding protein and its correlation with apoptosis in ischemia-reperfused rat heart

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12 December 2020

Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway. Divergence from downstream CT-1 signals for myocardial cell hypertrophy

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12 December 2020

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

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12 December 2020

A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen

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12 December 2020

Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family

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12 December 2020

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

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12 December 2020

Glucose uptake and glycolysis reduce hypoxia-induced apoptosis in cultured neonatal rat cardiac myocytes

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12 December 2020

Carvedilol inhibits activation of stress-activated protein kinase and reduces reperfusion injury in perfused rabbit heart

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12 December 2020

Caspases: enemies within

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12 December 2020

Bcl-2 and Bax expression in adult rat hearts after coronary occlusion: age-associated differences.

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12 December 2020

Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis

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12 December 2020

Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell

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12 December 2020

Tumor necrosis factor-alpha and tumor necrosis factor receptors in the failing human heart

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12 December 2020

Fas pathway is a critical mediator of cardiac myocyte death and MI during ischemia-reperfusion in vivo

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12 December 2020

Necrosis and apoptosis: distinct modes of cell death with fundamentally different significance

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12 December 2020

Stretch-induced programmed myocyte cell death

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12 December 2020

Mitochondria and apoptosis

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12 December 2020

Bid is cleaved by calpain to an active fragment in vitro and during myocardial ischemia/reperfusion

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12 December 2020

Inhibition of extracellular signal-regulated kinase enhances Ischemia/Reoxygenation-induced apoptosis in cultured cardiac myocytes and exaggerates reperfusion injury in isolated perfused heart

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12 December 2020

Hypoxia induces apoptosis with enhanced expression of Fas antigen messenger RNA in cultured neonatal rat cardiomyocytes

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12 December 2020

Caspase inhibition reduces myocyte cell death induced by myocardial ischemia and reperfusion in vivo

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12 December 2020

The mitochondrial apoptotic pathway is activated by serum and glucose deprivation in cardiac myocytes

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12 December 2020

Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarction

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12 December 2020

A novel domain within the 55 kd TNF receptor signals cell death

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12 December 2020

Staurosporine-induced apoptosis in cardiomyocytes: A potential role of caspase-3.

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12 December 2020

Apoptosis in human acute myocardial infarction

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12 December 2020

"Stress-responsive" mitogen-activated protein kinases (c-Jun N-terminal kinases and p38 mitogen-activated protein kinases) in the myocardium

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12 December 2020

Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy

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12 December 2020

Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death)

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12 December 2020

The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice

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12 December 2020

Mitochondrial endonuclease G is important for apoptosis in C. elegans.

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12 December 2020

Calcineurin functions in Ca(2+)-activated cell death in mammalian cells

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12 December 2020

Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death

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12 December 2020

Functional consequences of caspase activation in cardiac myocytes

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12 December 2020

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

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12 December 2020

Caspases on the brain

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12 December 2020

Antioxidants attenuate myocyte apoptosis in the remote non-infarcted myocardium following large myocardial infarction

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12 December 2020

Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis

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12 December 2020

Effect of beta-blockers on circulating levels of inflammatory and anti-inflammatory cytokines in patients with dilated cardiomyopathy

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12 December 2020

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

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12 December 2020

Circulating tumour necrosis factor-alpha (cachectin) in myocardial infarction.

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12 December 2020

Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats

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12 December 2020

Direct measurement of free radical generation following reperfusion of ischemic myocardium

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12 December 2020

The mitochondrial death/life regulator in apoptosis and necrosis

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12 December 2020

Elevated circulating levels and cardiac secretion of soluble Fas ligand in patients with congestive heart failure

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12 December 2020

Thapsigargin induces a calmodulin/calcineurin-dependent apoptotic cascade responsible for the death of prostatic cancer cells.

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12 December 2020

Modulation of cytokine-induced cardiac myocyte apoptosis by nitric oxide, Bak, and Bcl-x.

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12 December 2020

The tissue distribution of tumor necrosis factor biosynthesis during endotoxemia

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12 December 2020

Tumor necrosis factor-alpha pretreatment is protective in a rat model of myocardial ischemia-reperfusion injury

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12 December 2020

Apoptosis in heart failure: release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathy

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12 December 2020

Tumor necrosis factor-alpha gene and protein expression in adult feline myocardium after endotoxin administration

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12 December 2020

Evidence of Apoptosis in Arrhythmogenic Right Ventricular Dysplasia

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12 December 2020

Morphological and molecular characterization of adult cardiomyocyte apoptosis during hypoxia and reoxygenation

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12 December 2020

Calcium-activated neutral protease inhibitor (E-64c) and reperfusion for experimental myocardial infarction

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12 December 2020

Expression and functional significance of tumor necrosis factor receptors in human myocardium

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12 December 2020

Release of cytochrome c from heart mitochondria is induced by high Ca2+ and peroxynitrite and is responsible for Ca(2+)-induced inhibition of substrate oxidation.

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12 December 2020

Lethal effect of the anti-Fas antibody in mice

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12 December 2020

Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human

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12 December 2020

Regulation of bcl-2 family proteins during development and in response to oxidative stress in cardiac myocytes: association with changes in mitochondrial membrane potential

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12 December 2020

Pharmacology of caspase inhibitors in rabbit cardiomyocytes subjected to metabolic inhibition and recovery

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12 December 2020

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

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12 December 2020

Attenuation of ischemia/reperfusion injury in rats by a caspase inhibitor

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12 December 2020

Heart-targeted overexpression of caspase3 in mice increases infarct size and depresses cardiac function.

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12 December 2020

An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

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12 December 2020

Distinct initiator caspases are required for the induction of apoptosis in cardiac myocytes during ischaemia versus reperfusion injury

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12 December 2020

Activation of the JNK pathway is important for cardiomyocyte death in response to simulated ischemia

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12 December 2020

Expression of bcl-2 protein, an inhibitor of apoptosis, and Bax, an accelerator of apoptosis, in ventricular myocytes of human hearts with myocardial infarction

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12 December 2020

Involvement of CD95/Apo1/Fas in Cell Death After Myocardial Ischemia

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12 December 2020

Nifedipine does not induce but rather prevents apoptosis in cardiomyocytes

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12 December 2020

Calcineurin transgenic mice have mitochondrial dysfunction and elevated superoxide production

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12 December 2020

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

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12 December 2020

Tumor Necrosis Factor Soluble Receptors in Patients With Various Degrees of Congestive Heart Failure

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12 December 2020

Intracellular calcium, DNase activity and myocyte apoptosis in aging Fischer 344 rats

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12 December 2020

Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo: An apoptosis-independent model of dilated heart failure

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12 December 2020

Upregulation of the Bcl-2 family of proteins in end stage heart failure

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12 December 2020

Chronic Hypoxia Induces Apoptosis in Cardiac Myocytes: A Possible Role for Bcl-2-like Proteins

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12 December 2020

Fas-mediated apoptosis in adriamycin-induced cardiomyopathy in rats: In vivo study

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12 December 2020

Deoxyribonuclease I in mammalian tissues. Specificity of inhibition by actin

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12 December 2020

Reactive oxygen species regulate FLICE inhibitory protein (FLIP) and susceptibility to Fas-mediated apoptosis in cardiac myocytes

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12 December 2020

Increased cardiomyocyte apoptosis and changes in proapoptotic and antiapoptotic genes bax and bcl-2 during left ventricular adaptations to chronic pressure overload in the rat

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12 December 2020

Caspase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury

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12 December 2020

Negative lusitropy and abnormal calcium handling in hypoxic cardiac myocytes exposed to the calcium-sensitizer EMD 53998

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12 December 2020

Norepinephrine stimulates apoptosis in adult rat ventricular myocytes by activation of the beta-adrenergic pathway

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12 December 2020

Preconditioning rabbit cardiomyocytes: role of pH, vacuolar proton ATPase, and apoptosis

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12 December 2020

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

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12 December 2020

Overexpression of Bcl-2 attenuates apoptosis and protects against myocardial I/R injury in transgenic mice

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12 December 2020

ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases

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12 December 2020

Ultrastructural quantitation of mitochondria and myofilaments in cardiac muscle from 10 different animal species including man

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12 December 2020

The apoptotic regulatory protein ARC (apoptosis repressor with caspase recruitment domain) prevents oxidant stress-mediated cell death by preserving mitochondrial function

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12 December 2020

Calcium-activated neutral protease (calpain) system: structure, function, and regulation

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12 December 2020

Suppression or induction of apoptosis by opposing pathways downstream from calcium-activated calcineurin

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12 December 2020

Stimulation of the stress-activated mitogen-activated protein kinase subfamilies in perfused heart. p38/RK mitogen-activated protein kinases and c-Jun N-terminal kinases are activated by ischemia/reperfusion

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12 December 2020

Reperfusion injury induces apoptosis in rabbit cardiomyocytes

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12 December 2020

Tumor necrosis factor-alpha confers resistance to hypoxic injury in the adult mammalian cardiac myocyte.

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12 December 2020

Apoptosis in rat cardiac myocytes induced by Fas ligand: priming for Fas-mediated apoptosis with doxorubicin

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12 December 2020

Differential Activation of Signal Transduction Pathways in Human Hearts With Hypertrophy Versus Advanced Heart Failure

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12 December 2020

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

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12 December 2020

Blocking caspase-activated apoptosis improves contractility in failing myocardium

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12 December 2020

Activation of c-Jun N-terminal kinase promotes survival of cardiac myocytes after oxidative stress

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12 December 2020

Apoptosis in the failing human heart

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12 December 2020

Significant levels of oxidants are generated by isolated cardiomyocytes during ischemia prior to reperfusion

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12 December 2020

The mitochondrial permeability transition pore and its role in cell death

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12 December 2020

Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex.

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12 December 2020

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

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12 December 2020

Plasma Fas ligand, an inducer of apoptosis, and plasma soluble Fas, an inhibitor of apoptosis, in patients with chronic congestive heart failure.

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12 December 2020

Hypoxia predisposes neonatal rat ventricular myocytes to apoptosis induced by activation of the Fas (CD95/Apo-1) receptor: Fas activation and apoptosis in hypoxic myocytes

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12 December 2020

The stress-activated protein kinase subfamily of c-Jun kinases

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12 December 2020

Calcineurin is downstream of the inositol 1,4,5-trisphosphate receptor in the apoptotic and cell growth pathways.

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12 December 2020

Overexpression of thioredoxin-1 in transgenic mice attenuates adriamycin-induced cardiotoxicity

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12 December 2020

Apoptosis meets signal transduction: elimination of a BAD influence

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12 December 2020

Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

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12 December 2020

Reperfusion, not simulated ischemia, initiates intrinsic apoptosis injury in chick cardiomyocytes

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12 December 2020

Different signaling pathways induce apoptosis in endothelial cells and cardiac myocytes during ischemia/reperfusion injury

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12 December 2020

The mitochondrial permeability transition in toxic, hypoxic and reperfusion injury

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12 December 2020

Overexpression of Bax Protein and Enhanced Apoptosis in the Left Ventricle of Spontaneously Hypertensive Rats

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12 December 2020

Activation of c-Jun N-terminal kinases and p38-mitogen-activated protein kinases in human heart failure secondary to ischaemic heart disease

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12 December 2020

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

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12 December 2020

Apoptosis in ischemic and reperfused rat myocardium

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12 December 2020

Apoptotic pathway activation from mitochondria and death receptors without caspase-3 cleavage in failing human myocardium: fragile balance of myocyte survival?

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12 December 2020

Sensitivity to apoptosis signal, clearance rate, and ultrastructure of fas ligand-induced apoptosis in in vivo adult cardiac cells

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12 December 2020

Endonuclease G is an apoptotic DNase when released from mitochondria

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12 December 2020

Elevated DNase I levels in human idiopathic dilated cardiomyopathy: an indicator of apoptosis?

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12 December 2020

ARC inhibits cytochrome c release from mitochondria and protects against hypoxia-induced apoptosis in heart-derived H9c2 cells

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12 December 2020

Targeted disruption of the mouse Sod I gene makes the hearts vulnerable to ischemic reperfusion injury

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12 December 2020

Viral gene transfer of the antiapoptotic factor Bcl-2 protects against chronic postischemic heart failure

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12 December 2020

TAT protein transduction into isolated perfused hearts: TAT-apoptosis repressor with caspase recruitment domain is cardioprotective

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12 December 2020

Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats

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12 December 2020

An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischemia

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12 December 2020

Alternative splicing of the primary Fas transcript generating soluble Fas antagonists is suppressed in the failing human ventricular myocardium

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12 December 2020

Protection by Cyclosporin A of ischemia/reperfusion-induced damage in isolated rat hearts.

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12 December 2020

Mediation of cardioprotection by transforming growth factor-beta

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12 December 2020

Cocaine induces apoptosis in fetal myocardial cells through a mitochondria-dependent pathway

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12 December 2020

Caspase activation and mitochondrial cytochrome C release during hypoxia-mediated apoptosis of adult ventricular myocytes

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12 December 2020

Molecular characterization of mitochondrial apoptosis-inducing factor

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12 December 2020

Apoptosis in myocytes in end-stage heart failure

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12 December 2020

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

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12 December 2020

Essential myosin light chain as a target for caspase-3 in failing myocardium

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12 December 2020

Inhibition of anoxia-induced injury in heart myocytes by cyclosporin A

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12 December 2020

Tissue-specific pattern of stress kinase activation in ischemic/reperfused heart and kidney

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12 December 2020

Regulation of cardiomyocyte apoptosis in ischemic reperfused mouse heart by glutathione peroxidase

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12 December 2020

Caspases: the executioners of apoptosis

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12 December 2020

The Bcl-2 protein family: arbiters of cell survival

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12 December 2020

The voltage-independent B-type Ca2+ channel modulates apoptosis of cardiac myocytes

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12 December 2020

10.1023/B:JOCI.0000010421.56035.60

Identifiers

DOI

1 reference

PubMed ID

15031632

Dimensions Publication ID

9 August 2017

0 references

1 reference

PubMed ID

15031632