The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice (Q40388321)

20 September 2017

The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice (English)

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20 September 2017

8

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20 September 2017

O F Bueno

1

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20 September 2017

L J De Windt

2

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20 September 2017

K M Tymitz

3

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20 September 2017

S A Witt

4

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20 September 2017

T R Kimball

5

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20 September 2017

R Klevitsky

6

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20 September 2017

T E Hewett

7

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20 September 2017

D J Lefer

9

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20 September 2017

C F Peng

10

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20 September 2017

R N Kitsis

11

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20 September 2017

J D Molkentin

12

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20 September 2017

language of work or name

English

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publication date

1 December 2000

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20 September 2017

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19

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23

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20 September 2017

6341-6350

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describes a project that uses

20 September 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC305855/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo: An apoptosis-independent model of dilated heart failure

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Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling.

22 September 2017

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Cardiac-specific overexpression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failure

22 September 2017

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Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice.

22 September 2017

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Low- and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice

22 September 2017

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Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress

22 September 2017

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Organization and regulation of mitogen-activated protein kinase signaling pathways

22 September 2017

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22 September 2017

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Role of the stress-activated protein kinases in endothelin-induced cardiomyocyte hypertrophy

22 September 2017

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Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice

22 September 2017

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A calcineurin-dependent transcriptional pathway for cardiac hypertrophy

22 September 2017

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Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates.

22 September 2017

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A role for the p38 mitogen-activated protein kinase pathway in myocardial cell growth, sarcomeric organization, and cardiac-specific gene expression

22 September 2017

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Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats

22 September 2017

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Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53

22 September 2017

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Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy

22 September 2017

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Transgenic Gαq overexpression induces cardiac contractile failure in mice

22 September 2017

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Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block

22 September 2017

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Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart

22 September 2017

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Ultrasensitivity in the mitogen-activated protein kinase cascade

22 September 2017

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Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

22 September 2017

1 reference

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Differential activation of protein kinase C isoforms by endothelin-1 and phenylephrine and subsequent stimulation of p42 and p44 mitogen-activated protein kinases in ventricular myocytes cultured from neonatal rat hearts

22 September 2017

1 reference

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Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study

22 September 2017

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Inhibition of phosphatidylinositol 3-kinase activity by adenovirus-mediated gene transfer and its effect on insulin action

22 September 2017

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Enhanced left ventricular performance in endurance trained older men.

17 June 2018

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Mitogen-activated protein kinases mediate changes in gene expression, but not cytoskeletal organization associated with cardiac muscle cell hypertrophy

17 June 2018

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Adenovirus-mediated transfer of the muscle glycogen phosphorylase gene into hepatocytes confers altered regulation of glycogen metabolism

17 June 2018

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Increasing complexity of the Ras signaling pathway

17 June 2018

1 reference

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Stimulation of the p38 mitogen-activated protein kinase pathway in neonatal rat ventricular myocytes by the G protein-coupled receptor agonists, endothelin-1 and phenylephrine: a role in cardiac myocyte hypertrophy?

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305855

The MEKK-JNK pathway is stimulated by alpha1-adrenergic receptor and ras activation and is associated with in vitro and in vivo cardiac hypertrophy.

20 August 2018

1 reference

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Transgenic remodeling of the regulatory myosin light chains in the mammalian heart

20 August 2018

1 reference

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Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway. Divergence from downstream CT-1 signals for myocardial cell hypertrophy

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305855

Dissociation of p44 and p42 mitogen-activated protein kinase activation from receptor-induced hypertrophy in neonatal rat ventricular myocytes

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305855

Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305855

Local insulin-like growth factor I expression induces physiologic, then pathologic, cardiac hypertrophy in transgenic mice

20 August 2018

1 reference

12 December 2020

Targeted expression of a dominant-negative K(v)4.2 K(+) channel subunit in the mouse heart

1 reference

12 December 2020

beta(2)-adrenergic receptor overexpression exacerbates development of heart failure after aortic stenosis

1 reference

12 December 2020

Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy

1 reference

12 December 2020

Endothelin-1, phorbol esters and phenylephrine stimulate MAP kinase activities in ventricular cardiomyocytes

1 reference

12 December 2020

Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes

1 reference

12 December 2020

Exercise-induced cardiac hypertrophy is associated with an increased myocardial compliance

1 reference

12 December 2020

"Stress-responsive" mitogen-activated protein kinases (c-Jun N-terminal kinases and p38 mitogen-activated protein kinases) in the myocardium

1 reference

12 December 2020

Oxidative damage of cardiomyocytes is limited by extracellular regulated kinases 1/2-mediated induction of cyclooxygenase-2

1 reference

12 December 2020

Extracellular signal-regulated protein kinase activation is required for the anti-hypertrophic effect of atrial natriuretic factor in neonatal rat ventricular myocytes

1 reference

12 December 2020

The mitochondrial apoptotic pathway is activated by serum and glucose deprivation in cardiac myocytes

1 reference

12 December 2020

The Mitogen-activated Protein Kinase Kinase MEK1 Stimulates a Pattern of Gene Expression Typical of the Hypertrophic Phenotype in Rat Ventricular Cardiomyocytes

1 reference

12 December 2020

Adverse effects of chronic endogenous sympathetic drive induced by cardiac GS alpha overexpression

1 reference

12 December 2020

Depletion of mitogen-activated protein kinase using an antisense oligodeoxynucleotide approach downregulates the phenylephrine-induced hypertrophic response in rat cardiac myocytes

1 reference

12 December 2020

Protein kinase C, but not tyrosine kinases or Ras, plays a critical role in angiotensin II-induced activation of Raf-1 kinase and extracellular signal-regulated protein kinases in cardiac myocytes

1 reference

12 December 2020

Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase Pathways

1 reference

12 December 2020

TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice.

1 reference

12 December 2020

MAPK superfamily plays an important role in daunomycin-induced apoptosis of cardiac myocytes

1 reference

12 December 2020

Identifiers

DOI

10.1093/EMBOJ/19.23.6341

1 reference

20 September 2017

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20 September 2017

PubMed publication ID

11101507

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