Uncoupling protein 1 binds one nucleotide per monomer and is stabilized by tightly bound cardiolipin. (Q35698944)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26038550%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

title

Uncoupling protein 1 binds one nucleotide per monomer and is stabilized by tightly bound cardiolipin (English)

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16 February 2020

1

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16 February 2020

Edmund R.S. Kunji

series ordinal

3

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16 February 2020

author name string

Chrissie Willers

series ordinal

2

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16 February 2020

Paul G Crichton

series ordinal

4

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16 February 2020

language of work or name

English

0 references

publication date

18 May 2015

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Proceedings of the National Academy of Sciences of the United States of America

16 February 2020

published in

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16 February 2020

volume

112

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16 February 2020

page(s)

6973-6978

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16 February 2020

issue

22

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Trends in thermostability provide information on the nature of substrate, inhibitor, and lipid interactions with mitochondrial carriers

16 February 2020

cites work

1 reference

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Structures of yeast mitochondrial ADP/ATP carriers support a domain-based alternating-access transport mechanism

12 July 2018

1 reference

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UCP2 transports C4 metabolites out of mitochondria, regulating glucose and glutamine oxidation.

12 July 2018

1 reference

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Brown and beige fat: development, function and therapeutic potential

12 July 2018

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Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria

12 July 2018

1 reference

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Fatty acids change the conformation of uncoupling protein 1 (UCP1)

12 July 2018

1 reference

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Test systems to study the structure and function of uncoupling protein 1: a critical overview.

12 July 2018

1 reference

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The regulation and physiology of mitochondrial proton leak

12 July 2018

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Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins

12 July 2018

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The changed metabolic world with human brown adipose tissue: therapeutic visions.

12 July 2018

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Mitochondrial carriers function as monomers.

12 July 2018

1 reference

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Cardiolipin and mitochondrial carriers

12 July 2018

1 reference

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High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity

12 July 2018

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Identification and importance of brown adipose tissue in adult humans

12 July 2018

1 reference

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The mechanism of transport by mitochondrial carriers based on analysis of symmetry

12 July 2018

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The ADP and ATP transport in mitochondria and its carrier

12 July 2018

1 reference

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High membrane potential promotes alkenal-induced mitochondrial uncoupling and influences adenine nucleotide translocase conformation

12 July 2018

1 reference

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Microscale fluorescent thermal stability assay for membrane proteins

12 July 2018

1 reference

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Yeast mitochondrial ADP/ATP carriers are monomeric in detergents as demonstrated by differential affinity purification

12 July 2018

1 reference

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The yeast mitochondrial ADP/ATP carrier functions as a monomer in mitochondrial membranes

12 July 2018

1 reference

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Unexpected evidence for active brown adipose tissue in adult humans

12 July 2018

1 reference

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Yeast mitochondrial ADP/ATP carriers are monomeric in detergents

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4460439

Mitochondrial carriers in the cytoplasmic state have a common substrate binding site

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4460439

Structural basis for lipid-mediated interactions between mitochondrial ADP/ATP carrier monomers

12 July 2018

1 reference

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Ubiquinone is not required for proton conductance by uncoupling protein 1 in yeast mitochondria

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4460439

Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4460439

Uncoupling proteins: the issues from a biochemist point of view

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4460439

The mechanism of proton transport mediated by mitochondrial uncoupling proteins

12 July 2018

1 reference

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Effect of fatty acids on H+ transport activity of the reconstituted uncoupling protein.

12 July 2018

1 reference

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Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum

12 July 2018

1 reference

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Molecular aspects of isolated and reconstituted carrier proteins from animal mitochondria

12 July 2018

1 reference

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A procedure for the simultaneous determination of lipid and protein in biomembranes and other biological samples

12 July 2018

1 reference

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An improved procedure for reconstitution of the uncoupling protein and in-depth analysis of H+/OH- transport

12 July 2018

1 reference

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Dangerous liaisons between detergents and membrane proteins. The case of mitochondrial uncoupling protein 2.

12 July 2018

1 reference

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Lipid, detergent, and Coomassie Blue G-250 affect the migration of small membrane proteins in blue native gels: mitochondrial carriers migrate as monomers not dimers.

25 September 2018

1 reference

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Brown adipose tissue activity controls triglyceride clearance.

25 September 2018

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Mitochondrial bovine ADP/ATP carrier in detergent is predominantly monomeric but also forms multimeric species.

25 September 2018

1 reference

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UCP1 and defense against oxidative stress. 4-Hydroxy-2-nonenal effects on brown fat mitochondria are uncoupling protein 1-independent.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4460439

Native UCP1 displays simple competitive kinetics between the regulators purine nucleotides and fatty acids.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4460439

A mitochondrial uncoupling artifact can be caused by expression of uncoupling protein 1 in yeast

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4460439

Photoaffinity labeling of the nucleotide-binding site of the uncoupling protein from hamster brown adipose tissue

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4460439

Identification of the pH sensor for nucleotide binding in the uncoupling protein from brown adipose tissue

25 September 2018

1 reference

12 December 2020

The uncoupling protein from brown adipose tissue mitochondria is a dimer. A hydrodynamic study

1 reference

12 December 2020

Cold-induced alterations of phospholipid fatty acyl composition in brown adipose tissue mitochondria are independent of uncoupling protein-1

1 reference

12 December 2020

The uncoupling protein dimer can form a disulfide cross-link between the mobile C-terminal SH groups

1 reference

12 December 2020

Structure and function of the uncoupling protein from brown adipose tissue

1 reference

12 December 2020

ADP/ATP carrier protein from beef heart mitochondria has high amounts of tightly bound cardiolipin, as revealed by 31P nuclear magnetic resonance

1 reference

12 December 2020

Binding of ATP to uncoupling protein of brown fat mitochondria as studied by means of spin-labeled ATP derivatives

1 reference

12 December 2020

Characteristics of the isolated purine nucleotide binding protein from brown fat mitochondria

1 reference

12 December 2020

Identification by site-directed mutagenesis of three arginines in uncoupling protein that are essential for nucleotide binding and inhibition

1 reference

12 December 2020

[3H]GDP binding and thermogenin amount in brown adipose tissue mitochondria from cold-exposed rats

1 reference

12 December 2020

Isolation of the uncoupling protein from brown adipose tissue mitochondria

1 reference

12 December 2020

Fluorescent nucleotide derivatives as specific probes for the uncoupling protein: thermodynamics and kinetics of binding and the control by pH

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1503833112

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26038550%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26038550%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26038550%20AND%20SRC:MED&resulttype=core&format=json