Mitochondrial DNA damage is a hallmark of chemically induced and the R6/2 transgenic model of Huntington's disease (Q35706627)

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24 December 2019

title

Mitochondrial DNA damage is a hallmark of chemically induced and the R6/2 transgenic model of Huntington's disease (English)

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24 December 2019

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6

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24 December 2019

author name string

Karina Acevedo-Torres

1

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24 December 2019

Lexsy Berríos

2

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24 December 2019

Nydia Rosario

3

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24 December 2019

Vanessa Dufault

4

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24 December 2019

Serguei Skatchkov

5

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24 December 2019

Carlos A Torres-Ramos

7

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24 December 2019

Sylvette Ayala-Torres

8

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24 December 2019

language of work or name

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20 November 2008

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24 December 2019

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24 December 2019

volume

8

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24 December 2019

issue

1

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24 December 2019

page(s)

126-136

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OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells

24 December 2019

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3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme

27 July 2018

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Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro

27 July 2018

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Electrophysiological and morphological changes in striatal spiny neurons in R6/2 Huntington's disease transgenic mice

27 July 2018

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Oxidative stress and neuronal DNA fragmentation mediate age-dependent vulnerability to the mitochondrial toxin, 3-nitropropionic acid, in the mouse striatum

27 July 2018

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Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease

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Efficient repair of abasic sites in DNA by mitochondrial enzymes

27 July 2018

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Repair of oxidative damage to nuclear and mitochondrial DNA in mammalian cells

27 July 2018

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3-Nitropropionic acid animal model and Huntington's disease

27 July 2018

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Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia.

27 July 2018

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Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

27 July 2018

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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

27 July 2018

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Chronic 3-nitropropionic acid treatment in baboons replicates the cognitive and motor deficits of Huntington's disease

27 July 2018

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The base excision repair pathway

27 July 2018

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

27 July 2018

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Brain enzyme and clinical alterations induced in rats and mice by nitroaliphatic toxicants

27 July 2018

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Regional mitochondrial respiratory activity in Huntington's disease brain

27 July 2018

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Radiation-induced decomposition of the purine bases within DNA and related model compounds

27 July 2018

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Repair of alkali-labile sites within the mitochondrial DNA of RINr 38 cells after exposure to the nitrosourea streptozotocin

27 July 2018

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Dose ranging and efficacy study of high-dose coenzyme Q10 formulations in Huntington's disease mice

27 July 2018

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Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner.

25 September 2018

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3-nitropropionic acid-induced hydrogen peroxide, mitochondrial DNA damage, and cell death are attenuated by Bcl-2 overexpression in PC12 cells

25 September 2018

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25 September 2018

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25 September 2018

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Cell sorting experiments link persistent mitochondrial DNA damage with loss of mitochondrial membrane potential and apoptotic cell death

25 September 2018

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Age-dependent decline of DNA repair activity for oxidative lesions in rat brain mitochondria

25 September 2018

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Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease

25 September 2018

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25 September 2018

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Striatal oxidative damage parallels the expression of a neurological phenotype in mice transgenic for the mutation of Huntington's disease

25 September 2018

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Mitochondrial dysfunction and free radical damage in the Huntington R6/2 transgenic mouse.

25 September 2018

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Oxidative damage to mitochondrial DNA in Huntington's disease parietal cortex

25 September 2018

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Biochemical abnormalities and excitotoxicity in Huntington's disease brain.

25 September 2018

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Increased vulnerability to 3-nitropropionic acid in an animal model of Huntington's disease.

25 September 2018

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Partial inhibition of brain succinate dehydrogenase by 3-nitropropionic acid is sufficient to initiate striatal degeneration in rat.

25 September 2018

1 reference

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Quantifiable bradykinesia, gait abnormalities and Huntington's disease-like striatal lesions in rats chronically treated with 3-nitropropionic acid

25 September 2018

1 reference

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Mitochondrial defect in Huntington's disease caudate nucleus

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268004

Age-dependent vulnerability of the striatum to the mitochondrial toxin 3-nitropropionic acid.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268004

Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid

25 September 2018

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12 December 2020

Neuroprotective strategies for treatment of lesions produced by mitochondrial toxins: implications for neurodegenerative diseases

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12 December 2020

Involvement of oxidative stress in 3-nitropropionic acid neurotoxicity

1 reference

12 December 2020

Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells

1 reference

12 December 2020

Detection of DNA base-excision repair activity for oxidative lesions in adult rat brain mitochondria

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12 December 2020

Analysis of gene-specific DNA damage and repair using quantitative polymerase chain reaction

1 reference

12 December 2020

10.1016/J.DNAREP.2008.09.004

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18935984%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

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24 December 2019

PubMed publication ID

18935984

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