Alzheimer's disease: the two-hit hypothesis (Q35708114)

9 August 2017

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title

Alzheimer's disease: the two-hit hypothesis (English)

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9 August 2017

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3

George Perry

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9 August 2017

1

Xiongwei Zhu

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9 August 2017

4

Mark A Smith

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9 August 2017

2

Arun K Raina

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9 August 2017

publication date

1 April 2004

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9 August 2017

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9 August 2017

volume

3

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9 August 2017

issue

4

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9 August 2017

page(s)

219-226

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

9 August 2017

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7 January 2021

G1 phase progression: cycling on cue

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Apoptosis and the cell cycle.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Cell cycle events in neurons. Proliferation or death?

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditions.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Cell cycle markers in the hippocampus in Alzheimer's disease.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Ki-67 immunoreactivity in Alzheimer's disease and other neurodegenerative disorders

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

DNA replication precedes neuronal cell death in Alzheimer's disease.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Ectopic localization of phosphorylated histone H3 in Alzheimer's disease: a mitotic catastrophe?

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Elevated luteinizing hormone expression colocalizes with neurons vulnerable to Alzheimer's disease pathology

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Cell cycle proteins in Alzheimer's disease: plenty of wheels but no cycle.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Neuronal CDK7 in hippocampus is related to aging and Alzheimer disease.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Mitotic phosphoepitopes precede paired helical filaments in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Trk receptor alterations in Alzheimer's disease.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Detection of NGF-like activity in human brain tissue: increased levels in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Normal β-NGF content in Alzheimer's disease cerebral cortex and hippocampus

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Immunoreactive epidermal growth factor receptors in neuritic plaques from patients with Alzheimer's disease.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Epidermal growth factor receptor expression in demented and aged human brain.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

PDGF is associated with neuronal and glial alterations of Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Hepatocyte growth factor (HGF/SF) in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Insulin-like growth factor-I (IGF-I) immunoreactivity in the Alzheimer's disease temporal cortex and hippocampus.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Insulin-like growth factors and insulin-like growth factor binding proteins in cerebrospinal fluid and serum of patients with dementia of the Alzheimer type.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Basic fibroblast growth factor in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Induction of basic Fibroblast Growth Factor in Alzheimerʼs disease pathology

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Characterization of cytokine production, screening of lymphocyte subset patterns and in vitro apoptosis in healthy and Alzheimer's Disease (AD) individuals.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Cyclooxygenase (COX)-2 and cell cycle activity in a transgenic mouse model of Alzheimer's disease neuropathology.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Mitotic signaling by beta-amyloid causes neuronal death

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F x DP, in B-amyloid-induced neuronal death

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Effect of advanced glycation endproducts on cell cycle and their relevance for Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Increased expression of cyclooxygenases and peroxisome proliferator-activated receptor-gamma in Alzheimer's disease brains

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

The role of mitogen-activated protein kinase pathways in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Elevated expression of p21ras is an early event in Alzheimer's disease and precedes neurofibrillary degeneration

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Aberrant expression of nNOS in pyramidal neurons in Alzheimer's disease is highly co-localized with p21ras and p16INK4a.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Signal transduction abnormalities in Alzheimer's disease: evidence of a pathogenic stimuli

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Distribution, levels, and activation of MEK1 in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Amyloid precursor protein in senile plaques of Alzheimer disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Phosphorylated c-MYC expression in Alzheimer disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Radical AGEing in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Neuronal oxidative stress precedes amyloid-beta deposition in Down syndrome

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Oxidative damage is the earliest event in Alzheimer disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Mitochondrial membrane fluidity and oxidative damage to mitochondrial DNA in aged and AD human brain.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Mitochondrial DNA damage as a mechanism of cell loss in Alzheimer's disease.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Quantitative assessment of DNA fragmentation and beta-amyloid deposition in insular cortex and midfrontal gyrus from patients with Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

DNA strand breaks in Alzheimer's disease.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

DNA damage distribution in the human brain as shown by in situ end labeling; area-specific differences in aging and Alzheimer disease in the absence of apoptotic morphology.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

DNA double-strand breaks measured by pulsed-field gel electrophoresis in irradiated lymphocytes from normal humans and those with Alzheimer's disease.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Oxidative damage in Alzheimer's.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

The nitration product 5-nitro-gamma-tocopherol is increased in the Alzheimer brain

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase-related protein 2, alpha-enolase and heat shock cognate 71.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Widespread peroxynitrite-mediated damage in Alzheimer's disease.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Proteomic identification of nitrated proteins in Alzheimer's disease brain

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking in Alzheimer disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Apolipoprotein E allele-dependent antioxidant activity in brains with Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Selective increase in lipid peroxidation in the inferior temporal cortex in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Decrease and structural modifications of phosphatidylethanolamine plasmalogen in the brain with Alzheimer disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Active glycation in neurofibrillary pathology of Alzheimer disease: N(epsilon)-(carboxymethyl) lysine and hexitol-lysine

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Advanced glycation end products contribute to amyloidosis in Alzheimer disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Increased protein glycation in cerebrospinal fluid of Alzheimer's disease.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Plasma protein glycation in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Advanced glycation end products co-localized with astrocytes and microglial cells in Alzheimer's disease brain

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

An immunochemical study on tau glycation in paired helical filaments

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Inducible nitric oxide synthase immunoreactivity in the Alzheimer disease hippocampus: association with Hirano bodies, neurofibrillary tangles, and senile plaques.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

The expression of key oxidative stress-handling genes in different brain regions in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Risk of Alzheimer's disease and duration of NSAID use.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

JNK and p38 stresskinases--degenerative effectors of signal-transduction-cascades in the nervous system

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

JNK activation is associated with intracellular beta-amyloid accumulation.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

A suicide note from Alzheimer disease neurons?

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Do neurons have a choice in death?

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Increased immunoreactivity for Jun- and Fos-related proteins in Alzheimer's disease: association with pathology

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Transient adaptation of oxidative stress in mammalian cells.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Transient adaptation to oxidative stress in yeast.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Regulation of glutathione S-transferase Ya subunit gene expression: identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Oxidative damage and cerebral aging

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Amyloid, the presenilins and Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Amyloid beta protein precursor is a mitogen

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

A possible role for the Alzheimer amyloid precursor protein in the regulation of epidermal basal cell proliferation

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

The biological role of the Alzheimer amyloid precursor protein in epithelial cells

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Alzheimer's disease: a dysfunction of the amyloid precursor protein(1).

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Reduction of trophic support enhances apoptosis in PC12 cells expressing Alzheimer's APP mutation and sensitizes cells to staurosporine-induced cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Beta-amyloid precursor protein transgenic mice that harbor diffuse A beta deposits but do not form plaques show increased ischemic vulnerability: role of inflammation

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Aberrant stress response associated with severe hypoglycemia in a transgenic mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Presenilin overexpression arrests cells in the G1 phase of the cell cycle. Arrest potentiated by the Alzheimer's disease PS2(N141I)mutant

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Familial Alzheimer's disease presenilin-1 mutants potentiate cell cycle arrest

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Presenilin 1 overexpressions in Chinese hamster ovary (CHO) cells decreases the phosphorylation of retinoblastoma protein: relevance for neurodegeneration.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Impaired cell cycle control of neuronal precursor cells in the neocortical primordium of presenilin-1-deficient mice

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Deficiency of presenilin-1 increases calcium-dependent vulnerability of neurons to oxidative stress in vitro

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Neurons overexpressing mutant presenilin-1 are more sensitive to apoptosis induced by endoplasmic reticulum-Golgi stress.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologically

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

A one-hit model of cell death in inherited neuronal degenerations

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

Brain trauma induces massive hippocampal neuron death linked to a surge in beta-amyloid levels in mice overexpressing mutant amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900707-0

7 January 2021

10.1016/S1474-4422(04)00707-0

Identifiers

DOI

1 reference

9 August 2017

1 reference