Exposing a hidden functional site of C-reactive protein by site-directed mutagenesis (Q35728529)

9 August 2017

Exposing a hidden functional site of C-reactive protein by site-directed mutagenesis (English)

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9 August 2017

Sanjay K Singh

1

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9 August 2017

Avinash Thirumalai

2

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9 August 2017

David J Hammond

3

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9 August 2017

Michael K Pangburn

4

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9 August 2017

Vinod K Mishra

5

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9 August 2017

David A Johnson

6

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9 August 2017

Antonio E Rusiñol

7

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9 August 2017

Alok Agrawal

8

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9 August 2017

language of work or name

English

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publication date

9 December 2011

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Journal of Biological Chemistry

9 August 2017

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9 August 2017

287

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9 August 2017

5

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9 August 2017

3550-3558

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describes a project that uses

9 August 2017

site-directed mutagenesis

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Molecular chaperones in protein folding and proteostasis

inferred from title

cites work

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Progress and challenges in translating the biology of atherosclerosis

12 July 2018

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No reduction of atherosclerosis in C-reactive protein (CRP)-deficient mice

12 July 2018

1 reference

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Atherosclerosis-related functions of C-reactive protein

12 July 2018

1 reference

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Identification of acidic pH-dependent ligands of pentameric C-reactive protein

12 July 2018

1 reference

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A unifying biologic explanation for "high-sensitivity" C-reactive protein and "low-grade" inflammation

12 July 2018

1 reference

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Lack of effect of a single injection of human C-reactive protein on murine lupus or nephrotoxic nephritis

12 July 2018

1 reference

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Human C-reactive protein does not promote atherosclerosis in transgenic rabbits.

12 July 2018

1 reference

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Macrophages create an acidic extracellular hydrolytic compartment to digest aggregated lipoproteins

12 July 2018

1 reference

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The binding of C-reactive protein, in the presence of phosphoethanolamine, to low-density lipoproteins is due to phosphoethanolamine-generated acidic pH.

12 July 2018

1 reference

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ESBRI: a web server for evaluating salt bridges in proteins

12 July 2018

1 reference

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The protective function of human C-reactive protein in mouse models of Streptococcus pneumoniae infection

12 July 2018

1 reference

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C-reactive protein and systemic lupus erythematosus

12 July 2018

1 reference

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Plant immunity requires conformational changes [corrected] of NPR1 via S-nitrosylation and thioredoxins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271008

C-reactive protein-bound enzymatically modified low-density lipoprotein does not transform macrophages into foam cells

12 July 2018

1 reference

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Human C-reactive protein promotes oxidized low density lipoprotein uptake and matrix metalloproteinase-9 release in Wistar rats

12 July 2018

1 reference

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Human C-reactive protein slows atherosclerosis development in a mouse model with human-like hypercholesterolemia

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271008

Defective complement control of factor H (Y402H) and FHL-1 in age-related macular degeneration

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271008

The factor H variant associated with age-related macular degeneration (His-384) and the non-disease-associated form bind differentially to C-reactive protein, fibromodulin, DNA, and necrotic cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271008

Human C-reactive protein protects mice from Streptococcus pneumoniae infection without binding to pneumococcal C-polysaccharide

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271008

Enhanced extracellular lipid accumulation in acidic environments.

12 July 2018

1 reference

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Role of the property of C-reactive protein to activate the classical pathway of complement in protecting mice from pneumococcal infection

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271008

Transgenic human C-reactive protein is not proatherogenic in apolipoprotein E-deficient mice.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271008

12 July 2018

1 reference

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Studies of acute phase protein. I. An immunohistochemical method for the localization of Cx-reactive protein in rabbits. Association with necrosis in local inflammatory lesions

12 July 2018

1 reference

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THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUM

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271008

C-reactive protein binds to both oxidized LDL and apoptotic cells through recognition of a common ligand: Phosphorylcholine of oxidized phospholipids

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271008

Relationship between ion pair geometries and electrostatic strengths in proteins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271008

Regulation of complement activation by C-reactive protein: targeting the complement inhibitory activity of factor H by an interaction with short consensus repeat domains 7 and 8-11.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271008

The physiological structure of human C-reactive protein and its complex with phosphocholine

12 July 2018

1 reference

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SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271008

Does an acidic pH explain why low density lipoprotein is oxidised in atherosclerotic lesions?

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271008

Three dimensional structure of human C-reactive protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271008

Kinetic and thermodynamic analysis of the control of C3b by the complement regulatory proteins factors H and I

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271008

Specificity of C-reactive protein for choline phosphate residues of pneumococcal C-polysaccharide.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271008

Probing the phosphocholine-binding site of human C-reactive protein by site-directed mutagenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271008

Decrease in pH strongly enhances binding of native, proteolyzed, lipolyzed, and oxidized low density lipoprotein particles to human aortic proteoglycans

12 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.310011

Hypoxia-sensitive molecules may modulate the development of atherosclerosis in sleep apnoea syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.310011

Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.310011

Binding of C-reactive protein to modified low-density-lipoprotein particles: identification of cholesterol as a novel ligand for C-reactive protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.310011

Role of C-reactive protein in atherogenesis: can the apolipoprotein E knockout mouse provide the answer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.310011

No effect of C-reactive protein on early atherosclerosis development in apolipoprotein E*3-leiden/human C-reactive protein transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.310011

Continuously-infused human C-reactive protein is neither proatherosclerotic nor proinflammatory in apolipoprotein E-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.310011

Significance of the pH-induced conformational changes in the structure of C-reactive protein measured by dual polarization interferometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.310011

A redox switch in C-reactive protein modulates activation of endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.310011

Prevention and reversal of nephritis in MRL/lpr mice with a single injection of C-reactive protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.310011

Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.310011

No effect of C-reactive protein on early atherosclerosis in LDLR-/- / human C-reactive protein transgenic mice

21 January 2018

1 reference

12 December 2020

Delayed lupus onset in (NZB x NZW)F1 mice expressing a human C-reactive protein transgene

1 reference

12 December 2020

Models to study atherosclerosis: a mechanistic insight

1 reference

12 December 2020

C-reactive protein inhibits pneumococcal activation of the alternative pathway by increasing the interaction between factor H and C3b

1 reference

12 December 2020

pH Heterogeneity of human and rabbit atherosclerotic plaques; a new insight into detection of vulnerable plaque

1 reference

12 December 2020

7-Hydroperoxycholesterol and its products in oxidized low density lipoprotein and human atherosclerotic plaque

1 reference

12 December 2020

Interactions of C-reactive protein with low-density lipoproteins: implications for an active role of modified C-reactive protein in atherosclerosis

1 reference

12 December 2020

Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts*1

1 reference

12 December 2020

Complement and atherogenesis: binding of CRP to degraded, nonoxidized LDL enhances complement activation

1 reference

12 December 2020

Modulation of stimulus-dependent human platelet activation by C-reactive protein modified with active oxygen species

1 reference

12 December 2020

C-reactive protein and annexin A5 bind to distinct sites of negatively charged phospholipids present in oxidized low-density lipoprotein

1 reference

12 December 2020

Evidence of hypoxic areas within the arterial wall in vivo

1 reference

12 December 2020

Effects of calcium, magnesium, and phosphorylcholine on secondary structures of human C-reactive protein and serum amyloid P component observed by infrared spectroscopy

1 reference

12 December 2020

Comparative analyses of pentraxins: implications for protomer assembly and ligand binding

1 reference

12 December 2020

Calcium ion binding regions in C-reactive protein: location and regulation of conformational changes

1 reference

12 December 2020

C-reactive protein in the arterial intima: role of C-reactive protein receptor-dependent monocyte recruitment in atherogenesis

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M111.310011

1 reference

9 August 2017

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9 August 2017

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