HIV-1 VACCINES. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies (Q35728947)

9 August 2017

title

HIV-1 VACCINES. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies (English)

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9 August 2017

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Lawrence Corey

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M Juliana McElrath

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Kaitlin Sawatzki

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Kathryn Jones

Kathryn Jones

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Guido Ferrari

Guido Ferrari

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John R. Mascola

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John R Mascola

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David C Montefiori

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Barton F Haynes

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Scott Hammer

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Magdalena E. Sobieszczyk

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Magdalena E Sobieszczyk

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Gary J Nabel

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Barney S Graham

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Lindsey R Baden

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Richard A Koup

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Georgia D Tomaras

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Krissey E Lloyd

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Thomas B Kepler

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Wilton B Williams

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Michael Keefer

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Gavin Churchyard

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Kelly E Seaton

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M Anthony Moody

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S Munir Alam

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Pinghuang Liu

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Justin Pollara

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Kevin Wiehe

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Shelly Karuna

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Doug Grove

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Ashley M Trama

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Matthew Z Tay

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Nathan Vandergrift

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Hua-Xin Liao

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Peter Gilbert

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Janine Maenza

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Nicole Grunenberg

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Robert Parks

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Jae-Sung Yu

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Hongshuo Song

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Axin Hua

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Andrew Foulger

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Feng Gao

6

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Ruijun Zhang

10

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Dawn J Marshall

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John F Whitesides

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Xiaoying Shen

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Cecilia Morgan

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9 August 2017

language of work or name

English

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publication date

30 July 2015

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9 August 2017

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9 August 2017

volume

349

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9 August 2017

issue

6249

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9 August 2017

page(s)

aab1253

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CD40L-adjuvanted DNA/modified vaccinia virus Ankara simian immunodeficiency virus (SIV) vaccine enhances protection against neutralization-resistant mucosal SIV infection

9 August 2017

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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HIV-1 envelope gp41 antibodies can originate from terminal ileum B cells that share cross-reactivity with commensal bacteria

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Reconstructing a B-Cell Clonal Lineage. II. Mutation, Selection, and Affinity Maturation

12 July 2018

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Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers

12 July 2018

1 reference

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Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers

12 July 2018

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Antibody 8ANC195 Reveals a Site of Broad Vulnerability on the HIV-1 Envelope Spike

12 July 2018

1 reference

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IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria

12 July 2018

1 reference

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Specificity and 6-month durability of immune responses induced by DNA and recombinant modified vaccinia Ankara vaccines expressing HIV-1 virus-like particles

12 July 2018

1 reference

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Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer

12 July 2018

1 reference

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Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

12 July 2018

1 reference

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Efficacy trial of a DNA/rAd5 HIV-1 preventive vaccine

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562404

Microbial colonization influences early B-lineage development in the gut lamina propria.

12 July 2018

1 reference

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Infectious virion capture by HIV-1 gp120-specific IgG from RV144 vaccinees

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562404

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562404

A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562404

Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562404

Antigenicity and immunogenicity of RV144 vaccine AIDSVAX clade E envelope immunogen is enhanced by a gp120 N-terminal deletion

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562404

Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562404

Non-neutralizing antibodies in prevention of HIV infection

12 July 2018

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Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family

12 July 2018

1 reference

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Magnitude and breadth of the neutralizing antibody response in the RV144 and Vax003 HIV-1 vaccine efficacy trials

12 July 2018

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Isolation of HIV-1-neutralizing mucosal monoclonal antibodies from human colostrum

12 July 2018

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HIV-1 gp120 vaccine induces affinity maturation in both new and persistent antibody clonal lineages

12 July 2018

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Polyreactive antibodies in adaptive immune responses to viruses

12 July 2018

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H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccination

12 July 2018

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Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated

12 July 2018

1 reference

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Isolation of a human anti-HIV gp41 membrane proximal region neutralizing antibody by antigen-specific single B cell sorting

12 July 2018

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A phase IIA randomized clinical trial of a multiclade HIV-1 DNA prime followed by a multiclade rAd5 HIV-1 vaccine boost in healthy adults (HVTN204)

12 July 2018

1 reference

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Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors

12 July 2018

1 reference

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High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562404

Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562404

Isolation of a monoclonal antibody that targets the alpha-2 helix of gp120 and represents the initial autologous neutralizing-antibody response in an HIV-1 subtype C-infected individual

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562404

Rare antibodies from combinatorial libraries suggests an S.O.S. component of the human immunological repertoire

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562404

Crystal Structure and Size-Dependent Neutralization Properties of HK20, a Human Monoclonal Antibody Binding to the Highly Conserved Heptad Repeat 1 of gp41

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562404

A map of human genome variation from population-scale sequencing

12 July 2018

1 reference

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Safety and immunogenicity study of Multiclade HIV-1 adenoviral vector vaccine alone or as boost following a multiclade HIV-1 DNA vaccine in Africa

12 July 2018

1 reference

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Chiropteran types I and II interferon genes inferred from genome sequencing traces by a statistical gene-family assembler

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562404

Individual variation in the germline Ig gene repertoire inferred from variable region gene rearrangements.

12 July 2018

1 reference

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Priming immunization with DNA augments immunogenicity of recombinant adenoviral vectors for both HIV-1 specific antibody and T-cell responses

12 July 2018

1 reference

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A phase 1/2 study of a multiclade HIV-1 DNA plasmid prime and recombinant adenovirus serotype 5 boost vaccine in HIV-Uninfected East Africans (RV 172).

12 July 2018

1 reference

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Broad neutralization of human immunodeficiency virus type 1 mediated by plasma antibodies against the gp41 membrane proximal external region

12 July 2018

1 reference

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Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen

12 July 2018

1 reference

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Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses

12 July 2018

1 reference

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Initial B-cell responses to transmitted human immunodeficiency virus type 1: virion-binding immunoglobulin M (IgM) and IgG antibodies followed by plasma anti-gp41 antibodies with ineffective control of initial viremia

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562404

Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 DNA candidate vaccine

12 July 2018

1 reference

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Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 candidate vaccine delivered by a replication-defective recombinant adenovirus vector

12 July 2018

1 reference

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A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses

12 July 2018

1 reference

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SoDA: implementation of a 3D alignment algorithm for inference of antigen receptor recombinations

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562404

Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562404

Very low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reduced

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562404

Structure of the Escherichia coli RNA polymerase alpha subunit amino-terminal domain

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562404

Base-calling of automated sequencer traces using phred. II. Error probabilities

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562404

Base-calling of automated sequencer traces using phred. I. Accuracy assessment

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562404

Core structure of gp41 from the HIV envelope glycoprotein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562404

Expression of the immunoglobulin VH gene 51p1 is proportional to its germline gene copy number

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562404

Cross-neutralizing activity against divergent human immunodeficiency virus type 1 isolates induced by the gp41 sequence ELDKWAS.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562404

Identification of common molecular subsequences

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562404

High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies

12 July 2018

1 reference

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Structural basis for HIV-1 neutralization by a gp41 fusion intermediate-directed antibody.

25 September 2018

1 reference

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Evidence for a large compartment of IgM-expressing memory B cells in humans.

25 September 2018

1 reference

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Human IgM+IgD+ B cells, the major B cell subset in the peripheral blood, express V kappa genes with no or little somatic mutation throughout life

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562404

A different ontogenesis for chronic lymphocytic leukemia cases carrying stereotyped antigen receptors: molecular and computational evidence

25 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1126%2FSCIENCE.AAB1253

Phase I clinical evaluation of a six-plasmid multiclade HIV-1 DNA candidate vaccine

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26229114

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Role of BCR affinity in T cell dependent antibody responses in vivo

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26229114

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Antigen drives very low affinity B cells to become plasmacytes and enter germinal centers

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26229114

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCIENCE.AAB1253

1 reference

9 August 2017

1 reference

9 August 2017

1 reference