ATM deficiency impairs thymocyte maturation because of defective resolution of T cell receptor alpha locus coding end breaks (Q35748584)

10 August 2017

ATM deficiency impairs thymocyte maturation because of defective resolution of T cell receptor alpha locus coding end breaks (English)

1 reference

10 August 2017

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4

Richard J Hodes

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10 August 2017

Melanie S Vacchio

1

1 reference

10 August 2017

Alexandru Olaru

series ordinal

2

1 reference

10 August 2017

Ferenc Livak

series ordinal

3

1 reference

10 August 2017

language of work or name

English

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publication date

3 April 2007

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Proceedings of the National Academy of Sciences of the United States of America

10 August 2017

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10 August 2017

104

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10 August 2017

15

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10 August 2017

6323-6328

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ATM deficiency disrupts Tcra locus integrity and the maturation of CD4+CD8+ thymocytes.

10 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851038

The ATM-dependent DNA damage signaling pathway

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851038

ATM stabilizes DNA double-strand-break complexes during V(D)J recombination.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851038

ATM-dependent DNA damage surveillance in T-cell development and leukemogenesis: the DSB connection

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851038

Revision of T cell receptor {alpha} chain genes is required for normal T lymphocyte development.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851038

Regulated costimulation in the thymus is critical for T cell development: dysregulated CD28 costimulation can bypass the pre-TCR checkpoint

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851038

ATM is required for efficient recombination between immunoglobulin switch regions

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851038

Immunoglobulin class switch recombination is impaired in Atm-deficient mice

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851038

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851038

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851038

CD28 costimulation is required for in vivo induction of peripheral tolerance in CD8 T cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851038

RAG-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851038

Sensing of intermediates in V(D)J recombination by ATM.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851038

The role of recombination activating gene (RAG) reinduction in thymocyte development in vivo

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851038

The many substrates and functions of ATM

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851038

Immature thymocytes undergoing receptor rearrangements are resistant to an Atm-dependent death pathway activated in mature T cells by double-stranded DNA breaks

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851038

Recombinase-activating gene (RAG) 2-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851038

Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851038

Structure and function of the pre-T cell receptor

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851038

The genetic defect in ataxia-telangiectasia

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851038

Identification of V(D)J recombination coding end intermediates in normal thymocytes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851038

Atm-deficient mice: a paradigm of ataxia telangiectasia

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851038

T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851038

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851038

Hybrid T cell receptor genes formed by interlocus recombination in normal and ataxia-telangiectasis lymphocytes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851038

Exclusion and inclusion of α and β T cell receptor alleles

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851038

Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851038

Rescue of defective T cell development and function in Atm-/- mice by a functional TCR alpha beta transgene

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851038

Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo

25 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0611222104

A novel role for CD28 in thymic selection: elimination of CD28/B7 interactions increases positive selection

21 January 2018

1 reference

12 December 2020

Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo

1 reference

12 December 2020

Abnormal rearrangement within the alpha/delta T-cell receptor locus in lymphomas from Atm-deficient mice

1 reference

12 December 2020

Inhibition of T cell receptor expression and function in immature CD4+CD8+ cells by CD4

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0611222104

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10 August 2017

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10 August 2017

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