Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression (Q35760817)

10 August 2017

Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression (English)

1 reference

10 August 2017

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1 reference

1 reference

6

Lars Zender

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Günter Fingerle-Rowson

4

object named as

Günter Fingerle-Rowson

0 references

Matthias Dobbelstein

object named as

Matthias Dobbelstein

7

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author name string

Ramona Schulz

1

1 reference

10 August 2017

Natalia D Marchenko

2

1 reference

10 August 2017

Lena Holembowski

3

1 reference

10 August 2017

Günter Fingerle-Rowson

4

1 reference

10 August 2017

Marina Pesic

5

1 reference

10 August 2017

Lars Zender

6

1 reference

10 August 2017

Ute M Moll

8

1 reference

10 August 2017

language of work or name

English

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publication date

23 January 2012

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Journal of Experimental Medicine

10 August 2017

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10 August 2017

209

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10 August 2017

275-289

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10 August 2017

2

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describes a project that uses

10 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3280870/fullTextXML

inferred from PubMed Central ID database lookup

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Intratumor injection of the Hsp90 inhibitor 17AAG decreases tumor growth and induces apoptosis in a prostate cancer xenograft model

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IL-8 secreted in a macrophage migration-inhibitory factor- and CD74-dependent manner regulates B cell chronic lymphocytic leukemia survival

2 October 2017

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Null mutation for macrophage migration inhibitory factor (MIF) is associated with less aggressive bladder cancer in mice

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Macrophage migration inhibitory factor coordinates DNA damage response with the proteasomal control of the cell cycle

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Macrophage migration inhibitory factor (MIF) promotes cell survival by activation of the Akt pathway and role for CSN5/JAB1 in the control of autocrine MIF activity

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An acetylation site in the middle domain of Hsp90 regulates chaperone function

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Amplification of tumor hypoxic responses by macrophage migration inhibitory factor-dependent hypoxia-inducible factor stabilization.

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Inhibition of macrophage migration inhibitory factor or its receptor (CD74) attenuates growth and invasion of DU-145 prostate cancer cells

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2 October 2017

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2 October 2017

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2 October 2017

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Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors

2 October 2017

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A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

2 October 2017

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Macrophage migration inhibitory factor: a regulator of innate immunity

2 October 2017

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The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting

2 October 2017

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Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu

2 October 2017

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Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

2 October 2017

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The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents

2 October 2017

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TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90

2 October 2017

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Inhibition of MDM2 by hsp90 contributes to mutant p53 stabilization

2 October 2017

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The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting

2 October 2017

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HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice

2 October 2017

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A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis

2 October 2017

1 reference

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Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin

2 October 2017

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Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

2 October 2017

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Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

2 October 2017

1 reference

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Expression of macrophage migration inhibitory factor and CD74 in cervical squamous cell carcinoma.

2 October 2017

1 reference

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Elevated expression of macrophage migration inhibitory factor correlates with tumor recurrence and poor prognosis of patients with gliomas

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280870

HSP90 inhibition is effective in breast cancer: a phase II trial of tanespimycin (17-AAG) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280870

Histone deacetylase inhibitors repress macrophage migration inhibitory factor (MIF) expression by targeting MIF gene transcription through a local chromatin deacetylation.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280870

A tautomerase-null macrophage migration-inhibitory factor (MIF) gene knock-in mouse model reveals that protein interactions and not enzymatic activity mediate MIF-dependent growth regulation

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280870

Macrophage migration inhibitory factor (MIF) plays a critical role in pathogenesis of ultraviolet-B (UVB) -induced nonmelanoma skin cancer (NMSC).

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280870

MIF loss impairs Myc-induced lymphomagenesis.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280870

Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280870

Macrophage migration inhibitory factor MIF interferes with the Rb-E2F pathway

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280870

Macrophage migration inhibitory factor expression is increased in pituitary adenoma cell nuclei.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280870

Quantification of macrophage migration inhibitory factor mRNA expression in non-small cell lung cancer tissues and its clinical significance.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280870

17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280870

Expression of macrophage migration inhibitory factor in human breast cancer: association with nodal spread.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280870

Increased expression of macrophage migration inhibitory factor during progression to hypopharyngeal squamous cell carcinoma

25 September 2018

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12 December 2020

Protein expression profiles in human breast ductal carcinoma and histologically normal tissue

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12 December 2020

Pharmacokinetics and pharmacodynamics of 17-demethoxy 17-[[(2-dimethylamino)ethyl]amino]geldanamycin (17DMAG, NSC 707545) in C.B-17 SCID mice bearing MDA-MB-231 human breast cancer xenografts

1 reference

12 December 2020

Overexpression of macrophage migration inhibitory factor induces angiogenesis and deteriorates prognosis after radical resection for hepatocellular carcinoma

1 reference

12 December 2020

Therapeutic effects of radiolabeled 17-allylamino-17-demethoxygeldanamycin on human H460 nonsmall-cell lung carcinoma xenografts in mice

1 reference

12 December 2020

Increased stability of macrophage migration inhibitory factor (MIF) in DU-145 prostate cancer cells

1 reference

12 December 2020

Macrophage migration inhibitory factor: a probable link between inflammation and cancer

1 reference

12 December 2020

Macrophage migration inhibitory factor (MIF) gene polymorphisms are associated with increased prostate cancer incidence

1 reference

12 December 2020

Macrophage migration inhibitory factor deficiency is associated with altered cell growth and reduced susceptibility to Ras-mediated transformation

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20111117

1 reference

10 August 2017

1 reference

10 August 2017

1 reference