C/EBPalpha mutations in acute myeloid leukaemias (Q35762456)

10 August 2017

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title

C/EBPalpha mutations in acute myeloid leukaemias (English)

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10 August 2017

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Claus Nerlov

1

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PubMed ID

15122210

10 August 2017

language of work or name

English

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publication date

1 May 2004

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10 August 2017

Nature Reviews Cancer

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10 August 2017

4

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10 August 2017

394-400

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10 August 2017

5

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https://scigraph.springernature.com/pub.10.1038/nrc1363

10 August 2017

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cites work

Disruption of differentiation in human cancer: AML shows the way.

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Impaired energy homeostasis in C/EBP alpha knockout mice

31 March 2020

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Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice

31 March 2020

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Ectopic expression of the CCAAT/enhancer-binding protein alpha promotes the adipogenic program in a variety of mouse fibroblastic cells

31 March 2020

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CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors

31 March 2020

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Distinct C/EBP functions are required for eosinophil lineage commitment and maturation

31 March 2020

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A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: transcriptional activator lacking antimitotic activity

31 March 2020

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Increased expression of eukaryotic translation initiation factors eIF-4E and eIF-2 alpha in response to growth induction by c-myc

31 March 2020

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The amino terminal and E2F interaction domains are critical for C/EBP alpha-mediated induction of granulopoietic development of hematopoietic cells.

31 March 2020

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Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

31 March 2020

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Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia

31 March 2020

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Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias

31 March 2020

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Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA)

31 March 2020

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Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML.

31 March 2020

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The emergence of a C/EBPalpha mutation in the clonal evolution of MDS towards secondary AML.

31 March 2020

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Mutations of CEBPA in acute myeloid leukemia FAB types M1 and M2.

31 March 2020

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Establishment of the acute myeloid leukemia cell line Kasumi-6 from a patient with a dominant-negative mutation in the DNA-binding region of the C/EBPalpha gene.

31 March 2020

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AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia.

31 March 2020

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Down-modulation of the C/EBPalpha transcription factor in core binding factor acute myeloid leukemias

31 March 2020

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BCR-ABL suppresses C/EBPalpha expression through inhibitory action of hnRNP E2.

31 March 2020

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CCAAT/enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells

31 March 2020

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Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes.

31 March 2020

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Regulation of eosinophil-specific gene expression by a C/EBP-Ets complex and GATA-1.

31 March 2020

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CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation

31 March 2020

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Recruitment of p300 by C/EBPbeta triggers phosphorylation of p300 and modulates coactivator activity

31 March 2020

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Cooperation between C/EBPalpha TBP/TFIIB and SWI/SNF recruiting domains is required for adipocyte differentiation

31 March 2020

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CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter

31 March 2020

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Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions

31 March 2020

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CCAAT-enhancer binding protein: a component of a differentiation switch

31 March 2020

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Separation of C/EBPalpha-mediated proliferation arrest and differentiation pathways.

31 March 2020

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CCAAT/enhancer binding protein alpha regulates p21 protein and hepatocyte proliferation in newborn mice

31 March 2020

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C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4

31 March 2020

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The Rb/E2F pathway: expanding roles and emerging paradigms

31 March 2020

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C/EBPalpha inhibits cell growth via direct repression of E2F-DP-mediated transcription

31 March 2020

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E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo

31 March 2020

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c-Myc is a critical target for c/EBPalpha in granulopoiesis.

31 March 2020

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Inhibition of cell proliferation by C/EBP alpha occurs in many cell types, does not require the presence of p53 or Rb, and is not affected by large T-antigen

31 March 2020

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Cell cycle inhibition mediated by the outer surface of the C/EBPα basic region is required but not sufficient for granulopoiesis

31 March 2020

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The CCAAT enhancer-binding protein alpha (C/EBPalpha) requires a SWI/SNF complex for proliferation arrest

31 March 2020

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Rb-mediated chromatin structure regulation and transcriptional repression

31 March 2020

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The in vivo profile of transcription factors during neutrophil differentiation in human bone marrow

31 March 2020

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C/EBPbeta: a major PML-RARA-responsive gene in retinoic acid-induced differentiation of APL cells.

31 March 2020

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C/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesis

31 March 2020

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C/EBPepsilon -/- mice: increased rate of myeloid proliferation and apoptosis

31 March 2020

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Expression of C/EBPbeta from the C/ebpalpha gene locus is sufficient for normal hematopoiesis in vivo.

31 March 2020

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CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia

31 March 2020

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CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein

31 March 2020

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C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice

31 March 2020

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Aging reduces proliferative capacities of liver by switching pathways of C/EBPalpha growth arrest.

31 March 2020

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Glycogen synthase kinase 3 is an insulin-regulated C/EBPalpha kinase

31 March 2020

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Ras signaling enhances the activity of C/EBP alpha to induce granulocytic differentiation by phosphorylation of serine 248.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC1363

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10 August 2017

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PubMed ID

15122210