Gi-biased β2AR signaling links GRK2 upregulation to heart failure (Q35766985)

10 August 2017

title

Gi-biased β2AR signaling links GRK2 upregulation to heart failure (English)

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10 August 2017

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6

Erhe Gao

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Yibin Wang

object named as

Yibin Wang

8

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Edward G. Lakatta

11

object named as

Edward G Lakatta

1 reference

10 August 2017

Weizhong Zhu

1

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10 August 2017

Natalia Petrashevskaya

2

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10 August 2017

Shuxun Ren

3

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10 August 2017

Aizhi Zhao

4

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10 August 2017

Khalid Chakir

5

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10 August 2017

J Kurt Chuprun

7

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10 August 2017

Mark Talan

9

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10 August 2017

Gerald W Dorn

10

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10 August 2017

Walter J Koch

12

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10 August 2017

Arthur M Feldman

13

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10 August 2017

Rui-Ping Xiao

14

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10 August 2017

publication date

15 December 2011

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10 August 2017

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10 August 2017

volume

110

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10 August 2017

issue

2

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10 August 2017

page(s)

265-274

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Cardiac pressure overload hypertrophy is differentially regulated by β-adrenergic receptor subtypes

10 August 2017

cites work

1 reference

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2 October 2017

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Level of G protein–Coupled Receptor Kinase-2 Determines Myocardial Ischemia/Reperfusion Injury via Pro- and Anti-Apoptotic Mechanisms

2 October 2017

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Reduction of sympathetic activity via adrenal-targeted GRK2 gene deletion attenuates heart failure progression and improves cardiac function after myocardial infarction

2 October 2017

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Agonist dose-dependent phosphorylation by protein kinase A and G protein-coupled receptor kinase regulates beta2 adrenoceptor coupling to G(i) proteins in cardiomyocytes

2 October 2017

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Targeted transgenesis reveals discrete attenuator functions of GRK and PKA in airway beta2-adrenergic receptor physiologic signaling

2 October 2017

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GRK mythology: G-protein receptor kinases in cardiovascular disease

2 October 2017

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2 October 2017

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2 October 2017

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Differential functional expression of human myocardial G protein receptor kinases in left ventricular cardiac diseases

2 October 2017

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2 October 2017

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Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system

2 October 2017

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The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals

2 October 2017

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Beta-adrenergic signaling in the heart: dual coupling of the beta2-adrenergic receptor to G(s) and G(i) proteins

2 October 2017

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Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure

2 October 2017

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Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes

2 October 2017

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Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice.

2 October 2017

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Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.

2 October 2017

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Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function

2 October 2017

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Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling.

2 October 2017

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Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras

2 October 2017

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Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor

2 October 2017

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Loss of beta-adrenoceptor response in myocytes overexpressing the Na+/Ca(2+)-exchanger

2 October 2017

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The beta(2)-adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through G(i)-dependent coupling to phosphatidylinositol 3'-kinase

12 July 2018

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Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted mice

12 July 2018

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Targeted inhibition of cardiomyocyte Gi signaling enhances susceptibility to apoptotic cell death in response to ischemic stress

12 July 2018

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Cardioprotective and survival benefits of long-term combined therapy with beta2 adrenoreceptor (AR) agonist and beta1 AR blocker in dilated cardiomyopathy postmyocardial infarction.

25 September 2018

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Norepinephrine- and epinephrine-induced distinct beta2-adrenoceptor signaling is dictated by GRK2 phosphorylation in cardiomyocytes.

25 September 2018

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Lymphocyte levels of GRK2 (betaARK1) mirror changes in the LVAD-supported failing human heart: lower GRK2 associated with improved beta-adrenergic signaling after mechanical unloading.

25 September 2018

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Angiotensin converting enzyme inhibitors attenuated the expression of G-protein coupled receptor kinases in heart failure patients.

25 September 2018

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Crosstalk of beta-adrenergic receptor subtypes through Gi blunts beta-adrenergic stimulation of L-type Ca2+ channels in canine heart failure.

25 September 2018

1 reference

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Enhanced G(i) signaling selectively negates beta2-adrenergic receptor (AR)--but not beta1-AR-mediated positive inotropic effect in myocytes from failing rat hearts

25 September 2018

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Caveolar localization dictates physiologic signaling of beta 2-adrenoceptors in neonatal cardiac myocytes

25 September 2018

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Dilated cardiomyopathy and sudden death resulting from constitutive activation of protein kinase a.

25 September 2018

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Overexpression of beta 1 and beta 2 adrenergic receptors in rat atrial myocytes. Differential coupling to G protein-gated inward rectifier K(+) channels via G(s) and G(i)/o.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282829

Executive Summary: Heart Disease and Stroke Statistics—2010 Update

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282829

Cardiomyopathy induced by cardiac Gs alpha overexpression

15 November 2018

1 reference

12 December 2020

Minimally invasive aortic banding in mice: effects of altered cardiomyocyte insulin signaling during pressure overload

1 reference

12 December 2020

Na+/Ca2+ exchange linking beta2-adrenergic G(i) signaling to heart failure: associated defect of adrenergic contractile support

1 reference

12 December 2020

Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure

1 reference

12 December 2020

Hypersensitivity of Gi protein mediated muscarinic receptor adenylyl cyclase in chronic ischaemic heart failure in the rat

1 reference

12 December 2020

Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart

1 reference

12 December 2020

Increased levels of inhibitory G protein in myocardium with heart failure

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12 December 2020

Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes

1 reference

12 December 2020

Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure

1 reference

12 December 2020

The enigma of beta2-adrenergic receptor Gi signaling in the heart: the good, the bad, and the ugly

1 reference

12 December 2020

10.1161/CIRCRESAHA.111.253260

Identifiers

DOI

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10 August 2017

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10 August 2017

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