Beta-cell failure in the pathogenesis of type 2 diabetes mellitus (Q35767284)

10 August 2017

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title

Beta-cell failure in the pathogenesis of type 2 diabetes mellitus (English)

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10 August 2017

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Jeanne H Steppel

1

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PubMed ID

15132880

10 August 2017

Edward S Horton

series ordinal

2

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10 August 2017

1 June 2004

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10 August 2017

Current diabetes report

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10 August 2017

4

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10 August 2017

3

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10 August 2017

169-175

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https://scigraph.springernature.com/pub.10.1007/s11892-004-0019-3

10 August 2017

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cites work

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Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle

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The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes

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Extensive islet amyloid formation is induced by development of Type II diabetes mellitus and contributes to its progression: pathogenesis of diabetes in a mouse model

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Loss of early phase of insulin release in humans impairs glucose tolerance and blunts thermic effect of glucose

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Preservation of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk hispanic women

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History of gestational diabetes leads to distinct metabolic alterations in nondiabetic African-American women with a parental history of type 2 diabetes

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Reduced beta-cell compensation to the insulin resistance associated with obesity in members of caucasian familial type 2 diabetic kindreds.

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Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

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Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM. Evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative.

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Beta-cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the U.S.

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Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats

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Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells

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Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets

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Physiological importance of deficiency in early prandial insulin secretion in non-insulin-dependent diabetes

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Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose

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12 December 2020

10.1007/S11892-004-0019-3

Identifiers

DOI

1 reference

10 August 2017

1 reference

PubMed ID

15132880