The role of vitamin D in the FGF23, klotho, and phosphate bone-kidney endocrine axis (Q35784205)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21932165%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

review article

1 reference

title

The role of vitamin D in the FGF23, klotho, and phosphate bone-kidney endocrine axis (English)

1 reference

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13 February 2020

0 references

8

1 reference

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13 February 2020

author name string

Mark R Haussler

1

1 reference

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13 February 2020

G Kerr Whitfield

2

1 reference

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13 February 2020

Ichiro Kaneko

3

1 reference

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13 February 2020

Ryan Forster

4

1 reference

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13 February 2020

Rimpi Saini

5

1 reference

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13 February 2020

Jui-Cheng Hsieh

6

1 reference

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13 February 2020

Carol A Haussler

7

1 reference

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13 February 2020

publication date

1 March 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21932165%20AND%20SRC:MED&resulttype=core&format=json

Reviews in Endocrine and Metabolic Disorders

13 February 2020

published in

1 reference

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13 February 2020

volume

13

1 reference

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13 February 2020

issue

1

1 reference

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13 February 2020

page(s)

57-69

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https://scigraph.springernature.com/pub.10.1007/s11154-011-9199-8

13 February 2020

exact match

0 references

cites work

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The FGF23-Klotho axis: endocrine regulation of phosphate homeostasis

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Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome

12 July 2018

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1,25-Dihydroxyvitamin D3/VDR-mediated induction of FGF23 as well as transcriptional control of other bone anabolic and catabolic genes that orchestrate the regulation of phosphate and calcium mineral metabolism.

12 July 2018

1 reference

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FGF23 induces expression of two isoforms of NAB2, which are corepressors of Egr-1.

12 July 2018

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Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts

12 July 2018

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Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D.

12 July 2018

1 reference

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Hereditary hypophosphatemic rickets with hypercalciuria is caused by mutations in the sodium-phosphate cotransporter gene SLC34A3.

12 July 2018

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1alpha,25-Dihydroxyvitamin D3 upregulates FGF23 gene expression in bone: the final link in a renal-gastrointestinal-skeletal axis that controls phosphate transport

12 July 2018

1 reference

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Cellular signaling by fibroblast growth factor receptors

12 July 2018

1 reference

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Circulating FGF-23 is regulated by 1alpha,25-dihydroxyvitamin D3 and phosphorus in vivo

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3288475

FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3288475

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3288475

Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system

12 July 2018

1 reference

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1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system

12 July 2018

1 reference

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In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage

12 July 2018

1 reference

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Regulation of intestinal Na+-dependent phosphate co-transporters by a low-phosphate diet and 1,25-dihydroxyvitamin D3

12 July 2018

1 reference

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Regulation of type II renal Na+-dependent inorganic phosphate transporters by 1,25-dihydroxyvitamin D3. Identification of a vitamin D-responsive element in the human NAPi-3 gene

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3288475

Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3288475

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3288475

Active serum vitamin D levels are inversely correlated with coronary calcification

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3288475

Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3288475

Sirtuin 1 retards hyperphosphatemia-induced calcification of vascular smooth muscle cells.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3288475

Ablation of vitamin D signaling rescues bone, mineral, and glucose homeostasis in Fgf-23 deficient mice.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3288475

Genetic dissection of phosphate- and vitamin D-mediated regulation of circulating Fgf23 concentrations

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3288475

Vitamin D and phosphate regulate fibroblast growth factor-23 in K-562 cells

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3288475

Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: A longitudinal, nested case‐control study in the Nordic countries

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3288475

Klotho protein protects against endothelial dysfunction.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3288475

Vitamin D and prevention of cancer--ready for prime time?

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21932165

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Endothelial dysfunction in the klotho mouse and downregulation of klotho gene expression in various animal models of vascular and metabolic diseases

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21932165

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

[Fibroblast growth factor (FGF) 23 works as a phosphate-regulating hormone and is involved in the pathogenesis of several disorders of phosphate metabolism]

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21932165

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S11154-011-9199-8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21932165%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21932165%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference