Raltegravir in HIV-1 infection: Safety and Efficacy in Treatment-naïve Patients (Q35789343)

10 August 2017

title

Raltegravir in HIV-1 infection: Safety and Efficacy in Treatment-naïve Patients (English)

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10 August 2017

1 reference

Krishan K Pandey

1

1 reference

10 August 2017

publication date

1 December 2011

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Clinical medicine reviews in therapeutics

10 August 2017

published in

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10 August 2017

volume

2012

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10 August 2017

issue

4

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10 August 2017

page(s)

13-30

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No effect of raltegravir intensification on viral replication markers in the blood of HIV-1-infected patients receiving antiretroviral therapy

10 August 2017

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Earlier versus later start of antiretroviral therapy in HIV-infected adults with tuberculosis

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Efficacy of a nucleoside-sparing regimen of darunavir/ritonavir plus raltegravir in treatment-naive HIV-1-infected patients (ACTG A5262).

12 July 2018

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Switching between raltegravir resistance pathways analyzed by deep sequencing

12 July 2018

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Dolutegravir (S/GSK1349572) exhibits significantly slower dissociation than raltegravir and elvitegravir from wild-type and integrase inhibitor-resistant HIV-1 integrase-DNA complexes

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Clinical pharmacology profile of raltegravir, an HIV-1 integrase strand transfer inhibitor

12 July 2018

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Long-term safety from the raltegravir clinical development program

12 July 2018

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12 July 2018

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12 July 2018

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Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.

12 July 2018

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Cross-Resistance Profile Determination of Two Second-Generation HIV-1 Integrase Inhibitors Using a Panel of Recombinant Viruses Derived from Raltegravir-Treated Clinical Isolates

12 July 2018

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Lopinavir/Ritonavir: a review of its use in the management of HIV-1 infection

12 July 2018

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Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy

12 July 2018

1 reference

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Physical Trapping of HIV-1 Synaptic Complex by Different Structural Classes of Integrase Strand Transfer Inhibitors

12 July 2018

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The effect of raltegravir intensification on low-level residual viremia in HIV-infected patients on antiretroviral therapy: a randomized controlled trial

12 July 2018

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The HIV-1 integrase mutations Y143C/R are an alternative pathway for resistance to Raltegravir and impact the enzyme functions

12 July 2018

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12 July 2018

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Short-course raltegravir intensification does not reduce persistent low-level viremia in patients with HIV-1 suppression during receipt of combination antiretroviral therapy

12 July 2018

1 reference

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Retroviral intasome assembly and inhibition of DNA strand transfer

12 July 2018

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12 July 2018

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Early emergence of raltegravir resistance mutations in patients receiving HAART salvage regimens

12 July 2018

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HIV-1 Integrase Strand Transfer Inhibitors: Novel Insights into their Mechanism of Action.

12 July 2018

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Impact of Y143 HIV-1 integrase mutations on resistance to raltegravir in vitro and in vivo

12 July 2018

1 reference

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Elvitegravir: a new HIV integrase inhibitor

12 July 2018

1 reference

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Longitudinal analysis of raltegravir susceptibility and integrase replication capacity of human immunodeficiency virus type 1 during virologic failure

12 July 2018

1 reference

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Natural polymorphisms of human immunodeficiency virus type 1 integrase and inherent susceptibilities to a panel of integrase inhibitors

12 July 2018

1 reference

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Selective-advantage profile of human immunodeficiency virus type 1 integrase mutants explains in vivo evolution of raltegravir resistance genotypes.

12 July 2018

1 reference

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Effect of rifampin, a potent inducer of drug-metabolizing enzymes, on the pharmacokinetics of raltegravir

12 July 2018

1 reference

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Molecular Interactions between HIV-1 integrase and the two viral DNA ends within the synaptic complex that mediates concerted integration

12 July 2018

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Characterization and structural analysis of HIV-1 integrase conservation

12 July 2018

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Functional and structural characterization of the integrase from the prototype foamy virus

12 July 2018

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Inhibition of human immunodeficiency virus type 1 concerted integration by strand transfer inhibitors which recognize a transient structural intermediate

12 July 2018

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Rapid and durable antiretroviral effect of the HIV-1 Integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: results of a 48-week controlled study

12 July 2018

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In vitro inhibition of UDP glucuronosyltransferases by atazanavir and other HIV protease inhibitors and the relationship of this property to in vivo bilirubin glucuronidation

12 July 2018

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Integrase inhibitors to treat HIV/AIDS.

12 July 2018

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A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase

12 July 2018

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Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes

12 July 2018

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HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase

12 July 2018

1 reference

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Structure-based mutational analysis of the C-terminal DNA-binding domain of human immunodeficiency virus type 1 integrase: critical residues for protein oligomerization and DNA binding

12 July 2018

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Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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The DNA-binding domain of HIV-1 integrase has an SH3-like fold

12 July 2018

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Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro

12 July 2018

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Residues critical for retroviral integrative recombination in a region that is highly conserved among retroviral/retrotransposon integrases and bacterial insertion sequence transposases

12 July 2018

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Raltegravir once daily or twice daily in previously untreated patients with HIV-1: a randomised, active-controlled, phase 3 non-inferiority trial.

12 July 2018

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Long-term treatment with raltegravir or efavirenz combined with tenofovir/emtricitabine for treatment-naive human immunodeficiency virus-1-infected patients: 156-week results from STARTMRK.

25 September 2018

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A randomized cross-over study to compare raltegravir and efavirenz (SWITCH-ER study).

25 September 2018

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Clinical efficacy of raltegravir against B and non-B subtype HIV-1 in phase III clinical studies

25 September 2018

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Transmission of integrase strand-transfer inhibitor multidrug-resistant HIV-1: case report and response to raltegravir-containing antiretroviral therapy

25 September 2018

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Postprandial lipid effects of low-dose ritonavir vs. raltegravir in HIV-uninfected adults

25 September 2018

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Substitution of raltegravir for ritonavir-boosted protease inhibitors in HIV-infected patients: the SPIRAL study

25 September 2018

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Effect of low-, moderate-, and high-fat meals on raltegravir pharmacokinetics

25 September 2018

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Raltegravir versus Efavirenz regimens in treatment-naive HIV-1-infected patients: 96-week efficacy, durability, subgroup, safety, and metabolic analyses

25 September 2018

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HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects.

25 September 2018

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25 September 2018

1 reference

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Genotypic/phenotypic patterns of HIV-1 integrase resistance to raltegravir.

25 September 2018

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Sustained antiretroviral effect of raltegravir after 96 weeks of combination therapy in treatment-naive patients with HIV-1 infection

25 September 2018

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Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-naive patients with HIV-1 infection: a multicentre, double-blind randomised controlled trial

25 September 2018

1 reference

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Evolution of raltegravir resistance during therapy.

25 September 2018

1 reference

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Pharmacokinetics of raltegravir in individuals with UGT1A1 polymorphisms

25 September 2018

1 reference

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Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection

25 September 2018

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Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection

25 September 2018

1 reference

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Safety, tolerability, and pharmacokinetics of raltegravir after single and multiple doses in healthy subjects.

25 September 2018

1 reference

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Metabolism and disposition in humans of raltegravir (MK-0518), an anti-AIDS drug targeting the human immunodeficiency virus 1 integrase enzyme

25 September 2018

1 reference

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Induction of CYP3A4 by efavirenz in primary human hepatocytes: comparison with rifampin and phenobarbital

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289997

Cross-resistance Profile of the Novel Integrase Inhibitor Dolutegravir (S/GSK1349572) Using Clonal Viral Variants Selected in Patients Failing Raltegravir

25 September 2018

1 reference

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Initial results reported on raltegravir once-daily dosing

15 November 2018

1 reference

12 December 2020

Clinical experience of raltegravir-containing regimens in HIV-infected patients during rifampicin-containing treatment of tuberculosis

1 reference

12 December 2020

Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals

1 reference

12 December 2020

Pharmacokinetics of double-dose raltegravir in two patients with HIV infection and tuberculosis

1 reference

12 December 2020

Identifiers

DOI

10.4137/CMRT.S5022

1 reference

10 August 2017

1 reference

10 August 2017

1 reference