High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation. (Q35790526)

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scientific article published on 28 September 2015

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English	High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation.	scientific article published on 28 September 2015

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25 February 2020

High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation (English)

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Shun Shimohama

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25 February 2020

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Masato Maesako

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25 February 2020

Maiko Uemura

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Yoshitaka Tashiro

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25 February 2020

Kazuki Sasaki

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25 February 2020

Kiwamu Watanabe

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25 February 2020

Yasuha Noda

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25 February 2020

Karin Ueda

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25 February 2020

Megumi Asada-Utsugi

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25 February 2020

Masakazu Kubota

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25 February 2020

Katsuya Okawa

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25 February 2020

Kengo Uemura

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25 February 2020

Ayae Kinoshita

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25 February 2020

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28 September 2015

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25 February 2020

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25 February 2020

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25 February 2020

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25 February 2020

e0131199

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25 February 2020

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Creative Commons Attribution 4.0 International

28 September 2015

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Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy

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Continuation of exercise is necessary to inhibit high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice

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27 July 2018

Metabolic stress modulates Alzheimer's β-secretase gene transcription via SIRT1-PPARγ-PGC-1 in neurons

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27 July 2018

Exercise is more effective than diet control in preventing high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice

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27 July 2018

Adaptor protein 2-mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing.

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27 July 2018

Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis

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27 July 2018

Midlife overweight and obesity increase late-life dementia risk: a population-based twin study

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27 July 2018

Effect of glycogen synthase kinase 3 β-mediated presenilin 1 phosphorylation on amyloid β production is negatively regulated by insulin receptor cleavage

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27 July 2018

Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice

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The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential

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Aggregation of vascular risk factors and risk of incident Alzheimer disease

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Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2

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Characterization of the glycosylation profiles of Alzheimer's beta -secretase protein Asp-2 expressed in a variety of cell lines.

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Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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27 July 2018

Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant mu2 subunit and its effects on endocytosis

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Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

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Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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27 July 2018

Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

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27 July 2018

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

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Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

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A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

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25 September 2018

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25 September 2018

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25 September 2018

Protein organization in clathrin trimers

1 reference

https://pubmed.ncbi.nlm.nih.gov/26414661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced release of amyloid beta-protein from codon 670/671 "Swedish" mutant beta-amyloid precursor protein occurs in both secretory and endocytic pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/26414661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1371/JOURNAL.PONE.0131199

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25 February 2020

2015PLoSO..1031199M

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25 February 2020

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25 February 2020

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