Phosphotyrosine signaling analysis of site-specific mutations on EGFRvIII identifies determinants governing glioblastoma cell growth (Q35793511)

10 August 2017

title

Phosphotyrosine signaling analysis of site-specific mutations on EGFRvIII identifies determinants governing glioblastoma cell growth (English)

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10 August 2017

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10 August 2017

Alexander M Xu

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Frank B Furnari

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Frank B Furnari

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Forest M. White

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Forest M White

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author name string

Emily R Miraldi

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10 August 2017

Vibin A Kundukulam

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10 August 2017

Amanda M Del Rosario

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10 August 2017

Ryan A Flynn

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10 August 2017

Webster K Cavenee

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10 August 2017

publication date

11 May 2010

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10 August 2017

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10 August 2017

volume

6

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10 August 2017

issue

7

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10 August 2017

page(s)

1227-1237

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An integrated comparative phosphoproteomic and bioinformatic approach reveals a novel class of MPM-2 motifs upregulated in EGFRvIII-expressing glioblastoma cells

10 August 2017

cites work

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Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

12 July 2018

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Pyruvate kinase M2 is a phosphotyrosine-binding protein

12 July 2018

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Evolvable signaling networks of receptor tyrosine kinases: relevance of robustness to malignancy and to cancer therapy

12 July 2018

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Uncovering therapeutic targets for glioblastoma: a systems biology approach

12 July 2018

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Malignant astrocytic glioma: genetics, biology, and paths to treatment

12 July 2018

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Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma

12 July 2018

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Differential function of PTPalpha and PTPalpha Y789F in T cells and regulation of PTPalpha phosphorylation at Tyr-789 by CD45.

12 July 2018

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Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

12 July 2018

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Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses.

12 July 2018

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Genetic pathways to primary and secondary glioblastoma

12 July 2018

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Modeling HER2 effects on cell behavior from mass spectrometry phosphotyrosine data

12 July 2018

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Data-driven modelling of signal-transduction networks

12 July 2018

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Effects of HER2 overexpression on cell signaling networks governing proliferation and migration

12 July 2018

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ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice

12 July 2018

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Phosphotyrosine interactome of the ErbB-receptor kinase family

12 July 2018

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Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

12 July 2018

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A quantitative protein interaction network for the ErbB receptors using protein microarrays

12 July 2018

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Transactivating agonists of the EGF receptor require Tyr 845 phosphorylation for induction of DNA synthesis

12 July 2018

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Global phosphoproteome of HT-29 human colon adenocarcinoma cells

12 July 2018

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Enhanced transformation by a plasma membrane-associated met oncoprotein: activation of a phosphoinositide 3'-kinase-dependent autocrine loop involving hyaluronic acid and CD44.

12 July 2018

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Phosphotyrosine 1173 mediates binding of the protein-tyrosine phosphatase SHP-1 to the epidermal growth factor receptor and attenuation of receptor signaling

12 July 2018

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Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain

12 July 2018

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The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling

12 July 2018

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Enhanced tumorigenic behavior of glioblastoma cells expressing a truncated epidermal growth factor receptor is mediated through the Ras-Shc-Grb2 pathway

12 July 2018

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Differential modulation of mitogen-activated protein (MAP) kinase/extracellular signal-related kinase kinase and MAP kinase activities by a mutant epidermal growth factor receptor

12 July 2018

1 reference

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Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

12 July 2018

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A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity

12 July 2018

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Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

12 July 2018

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Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: implications for the etiology of multiple human cancers

12 July 2018

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Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo

12 July 2018

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Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor

12 July 2018

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Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

12 July 2018

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A module of negative feedback regulators defines growth factor signaling

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291333

Suppression of the phosphorylation of receptor tyrosine phosphatase-alpha on the Src-independent site tyrosine 789 by reactive oxygen species

25 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291333

Human Protein Tyrosine Phosphatase 1C (PTPN6) Gene Structure: Alternate Promoter Usage and Exon Skipping Generate Multiple Transcripts

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291333

25 September 2018

Identifiers

DOI

10.1039/C001196G

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10 August 2017

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10 August 2017

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