SUMOylation regulates telomere length homeostasis by targeting Cdc13. (Q35794091)

10 August 2017

SUMOylation regulates telomere length homeostasis by targeting Cdc13. (English)

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10 August 2017

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SUMO family protein SMT3 YDR510W

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ATP-dependent DNA helicase YKU70 YMR284W

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Rtt107p YHR154W

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Recombinase RAD52 YML032C

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Slx4p YLR135W

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Telomere-binding protein CDC13 YDL220C

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ATP-dependent DNA helicase YKU80 YMR106C

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DNA helicase PIF1 YML061C

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Xiaolan Zhao

5

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author name string

Lisa E Hang

1

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10 August 2017

Xianpeng Liu

2

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10 August 2017

Iris Cheung

3

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10 August 2017

Yan Yang

4

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10 August 2017

10 July 2011

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Nature Structural & Molecular Biology

10 August 2017

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10 August 2017

18

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10 August 2017

8

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10 August 2017

920-926

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https://scigraph.springernature.com/pub.10.1038/nsmb.2100

10 August 2017

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cites work

Structural bases of dimerization of yeast telomere protein Cdc13 and its interaction with the catalytic subunit of DNA polymerase α

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

CST meets shelterin to keep telomeres in check

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

Sumoylation of the BLM ortholog, Sgs1, promotes telomere-telomere recombination in budding yeast.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

DNA damage signalling prevents deleterious telomere addition at DNA breaks

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

Structural and Functional Insights into the Roles of the Mms21 Subunit of the Smc5/6 Complex

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

A genome-wide screen for essential yeast genes that affect telomere length maintenance

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

Rapid Cdc13 turnover and telomere length homeostasis are controlled by Cdk1-mediated phosphorylation of Cdc13.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

Distinct roles for yeast Stn1 in telomere capping and telomerase inhibition

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

Cdk1-dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

How telomerase reaches its end: mechanism of telomerase regulation by the telomeric complex.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

Topoisomerase I-dependent viability loss in saccharomyces cerevisiae mutants defective in both SUMO conjugation and DNA repair

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

Role of SUMO in the dynamics of telomere maintenance in fission yeast

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

Regulation of telomere elongation by the cyclin-dependent kinase CDK1.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

Control of Rad52 recombination activity by double-strand break-induced SUMO modification

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

Chromosome end protection plasticity revealed by Stn1p and Ten1p bypass of Cdc13p

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

Ku: a multifunctional protein involved in telomere maintenance

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

Defining the SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiae

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

Cell cycle-dependent regulation of yeast telomerase by Ku.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

Global analysis of protein sumoylation in Saccharomyces cerevisiae

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

Protein modification by SUMO

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

Interaction of Saccharomyces Cdc13p with Pol1p, Imp4p, Sir4p and Zds2p is involved in telomere replication, telomere maintenance and cell growth control

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

An E3-like factor that promotes SUMO conjugation to the yeast septins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

Telomerase subunit overexpression suppresses telomere-specific checkpoint activation in the yeast yku80 mutant

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

Cdc13 delivers separate complexes to the telomere for end protection and replication

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

Cdc13 both positively and negatively regulates telomere replication

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

Telomere-binding and Stn1p-interacting activities are required for the essential function of Saccharomyces cerevisiae Cdc13p

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

Cdc13 cooperates with the yeast Ku proteins and Stn1 to regulate telomerase recruitment

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated est1 protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

Identification of the single-strand telomeric DNA binding domain of the Saccharomyces cerevisiae Cdc13 protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

Subtelomeric repeat amplification is associated with growth at elevated temperature in yku70 mutants of Saccharomyces cerevisiae

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

Identification of yeast mutants with altered telomere structure

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

Sumoylation of RecQ helicase controls the fate of dysfunctional telomeres.

12 July 2018

1 reference

Multiple domains in Siz SUMO ligases contribute to substrate selectivity.

21 January 2018

1 reference

The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku.

21 January 2018

1 reference

Telomere length homeostasis is achieved via a switch between telomerase- extendible and -nonextendible states.

21 January 2018

1 reference

Global analysis of protein expression in yeast

21 January 2018

1 reference

The Slx5-Slx8 complex affects sumoylation of DNA repair proteins and negatively regulates recombination

21 January 2018

1 reference

Cell cycle-regulated attachment of the ubiquitin-related protein SUMO to the yeast septins

21 January 2018

1 reference

SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage

21 January 2018

1 reference

Cooperation of sumoylated chromosomal proteins in rDNA maintenance

21 January 2018

1 reference

Nucleoporins prevent DNA damage accumulation by modulating Ulp1-dependent sumoylation processes

21 January 2018

1 reference

TEL2, an essential gene required for telomere length regulation and telomere position effect in Saccharomyces cerevisiae

21 January 2018

1 reference

Two paralogs involved in transcriptional silencing that antagonistically control yeast life span

21 January 2018

1 reference

The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1.

21 January 2018

1 reference

The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291484

Global Map of SUMO Function Revealed by Protein-Protein Interaction and Genetic Networks

25 September 2018

1 reference

Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase

21 January 2018

1 reference

Cell cycle restriction of telomere elongation

31 March 2020

1 reference

Est1 and Cdc13 as comediators of telomerase access

31 March 2020

1 reference

Est1p as a cell cycle-regulated activator of telomere-bound telomerase

31 March 2020

1 reference

Delivery of yeast telomerase to a DNA break depends on the recruitment functions of Cdc13 and Est1

31 March 2020

1 reference

Curing Saccharomyces cerevisiae of the 2 micron plasmid by targeted DNA damage

31 March 2020

1 reference

Cloning-free genome alterations in saccharomyces cereuisiae using adaptamer-mediated PCR

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NSMB.2100

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Dimensions Publication ID

10 August 2017

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10 August 2017

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