The role of von Hippel-Lindau tumor suppressor protein and hypoxia in renal clear cell carcinoma (Q35794374)

10 August 2017

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title

The role of von Hippel-Lindau tumor suppressor protein and hypoxia in renal clear cell carcinoma (English)

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10 August 2017

Roxana I Sufan

1

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PubMed ID

15180922

10 August 2017

Michael A S Jewett

series ordinal

2

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PubMed ID

15180922

10 August 2017

Michael Ohh

series ordinal

3

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10 August 2017

1 July 2004

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American Journal of Physiology - Renal Physiology

10 August 2017

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10 August 2017

287

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10 August 2017

F1-6

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10 August 2017

1

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SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

10 August 2017

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Alternate choice of initiation codon produces a biologically active product of the von Hippel Lindau gene with tumor suppressor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Germline mutations in the von Hippel-Lindau disease tumor suppressor gene: correlations with phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Hereditary Renal-Cell Carcinoma Associated with a Chromosomal Translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Identification of intragenic mutations in the von Hippel-Lindau disease tumour suppressor gene and correlation with disease phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Oncogenic alterations of metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Comparative analysis of laparoscopic versus open partial nephrectomy for renal tumors in 200 patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Mutations of the VHL tumour suppressor gene in renal carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Validation of an integrated staging system toward improved prognostication of patients with localized renal cell carcinoma in an international population

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Tumour suppression by the human von Hippel-Lindau gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

21 January 2018

Cancer statistics, 2003.

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Tissue-specific expression of a constitutional 3;6 translocation: development of multiple bilateral renal-cell carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Consistent chromosome 3p deletion and loss of heterozygosity in renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Identification of the von Hippel-Lindau disease tumor suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Playing Tag with HIF: The VHL Story

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

The genetic basis of cancer of the kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Acidic pH enhances the invasive behavior of human melanoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Identification of the RNA polymerase II subunit hsRPB7 as a novel target of the von Hippel-Lindau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Expression of the von Hippel-Lindau disease tumour suppressor gene during human embryogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Detailed genetic mapping of the von Hippel-Lindau disease tumour suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Perspectives on oxygen sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Human carbonic anhydrases and carbonic anhydrase deficiencies

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Characterization of an oxygen/redox-dependent degradation domain of hypoxia-inducible factor alpha (HIF-alpha) proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Germline mutations in the vhl gene in patients presenting with phaeochromocytomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

In vivo expression of mRNAs encoding hypoxia-inducible factor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Genetic and functional analysis of the von Hippel-Lindau (VHL) tumour suppressor gene promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Oxygen sensing and signaling: impact on the regulation of physiologically important genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Direct Interaction of the β-Domain of VHL Tumor Suppressor Protein with the Regulatory Domain of Atypical PKC Isotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00424.2003

10.1152/AJPRENAL.00424.2003

21 January 2018

Identifiers

DOI

1 reference

10 August 2017

1 reference

PubMed ID

15180922