Polynuclear platinum anticancer drugs are more potent than cisplatin and induce cell cycle arrest in glioma. (Q35800638)

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28 January 2020

title

Polynuclear platinum anticancer drugs are more potent than cisplatin and induce cell cycle arrest in glioma (English)

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28 January 2020

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7

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author name string

Christine Billecke

1

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28 January 2020

Susan Finniss

2

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28 January 2020

Laura Tahash

3

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28 January 2020

Cathie Miller

4

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28 January 2020

Tom Mikkelsen

5

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28 January 2020

Nicholas P Farrell

6

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publication date

24 May 2006

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28 January 2020

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28 January 2020

volume

8

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28 January 2020

issue

3

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28 January 2020

page(s)

215-226

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Synthesis, characterization, and cytotoxicity of a novel highly charged trinuclear platinum compound. Enhancement of cellular uptake with charge

28 January 2020

cites work

1 reference

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Akt activation suppresses Chk2-mediated, methylating agent-induced G2 arrest and protects from temozolomide-induced mitotic catastrophe and cellular senescence

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Roles of tyrosine phosphorylation and cleavage of protein kinase Cdelta in its protective effect against tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis

11 July 2018

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Phase II studies of BBR3464, a novel tri-nuclear platinum complex, in patients with gastric or gastro-oesophageal adenocarcinoma.

11 July 2018

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Polynuclear platinum drugs.

11 July 2018

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EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

11 July 2018

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

11 July 2018

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Gene expression profiles in the cellular response to a multinuclear platinum complex

11 July 2018

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Long range 1,4 and 1,6-interstrand cross-links formed by a trinuclear platinum complex. Minor groove preassociation affects kinetics and mechanism of cross-link formation as well as adduct structure.

11 July 2018

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Cisplatin: mode of cytotoxic action and molecular basis of resistance

11 July 2018

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Chk1 and Chk2 kinases in checkpoint control and cancer

11 July 2018

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Validating survivin as a cancer therapeutic target

11 July 2018

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ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53.

11 July 2018

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The molecular basis and potential role of survivin in cancer diagnosis and therapy

11 July 2018

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Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53.

11 July 2018

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Requirement for ERK activation in cisplatin-induced apoptosis

11 July 2018

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Effect of extracellular signal-regulated kinase on p53 accumulation in response to cisplatin

11 July 2018

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BBR 3464: a novel triplatinum complex, exhibiting a preclinical profile of antitumor efficacy different from cisplatin

11 July 2018

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Cellular pharmacology of polynuclear platinum anti-cancer agents

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1871949

Comparison of cytotoxicity and cellular accumulation of polynuclear platinum complexes in L1210 murine leukemia cell lines

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1871949

Inhibition of extracellular signal-regulated protein kinase or c-Jun N-terminal protein kinase cascade, differentially activated by cisplatin, sensitizes human ovarian cancer cell line

11 July 2018

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A novel charged trinuclear platinum complex effective against cisplatin-resistant tumours: hypersensitivity of p53-mutant human tumour xenografts

11 July 2018

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Cisplatin-induced activation of mitogen-activated protein kinases in ovarian carcinoma cells: inhibition of extracellular signal-regulated kinase activity increases sensitivity to cisplatin

11 July 2018

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Biological consequences of trinuclear platinum complexes: comparison of [[trans-PtCl(NH3)2]2mu-(trans-Pt(NH3)2(H2N(CH2)6-NH2)2)]4+ (BBR 3464) with its noncovalent congeners

11 July 2018

1 reference

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Cooperative function of Chk1 and p38 pathways in activating G2 arrest following exposure to temozolomide

25 September 2018

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A phase I study of the trinuclear platinum compound, BBR 3464, in combination with protracted venous infusional 5-fluorouracil in patients with advanced cancer.

25 September 2018

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Reaction of polynuclear platinum antitumor compounds with reduced glutathione studied by multinuclear (1H, 1H-15N gradient heteronuclear single-quantum coherence, and 195Pt) NMR spectroscopy

25 September 2018

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Ras-mediated activation of ERK by cisplatin induces cell death independently of p53 in osteosarcoma and neuroblastoma cell lines.

25 September 2018

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DNA interstrand cross-links of the novel antitumor trinuclear platinum complex BBR3464. Conformation, recognition by high mobility group domain proteins, and nucleotide excision repair

25 September 2018

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A comparison of DNA binding profiles of dinuclear platinum compounds with polyamine linkers and the trinuclear platinum phase II clinical agent BBR3464.

25 September 2018

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In vitro and in vivo antitumor activity of the novel trinuclear platinum complex BBR 3464 in neuroblastoma.

25 September 2018

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The novel trinuclear platinum complex BBR3464 induces a cellular response different from cisplatin.

25 September 2018

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The Jun kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin

25 September 2018

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Response of brain tumors to chemotherapy, evaluated in a clinically relevant xenograft model

25 September 2018

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The cellular basis of the efficacy of the trinuclear platinum complex BBR 3464 against cisplatin-resistant cells

25 September 2018

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12 December 2020

Clinical and pharmacological phase I study with accelerated titration design of a daily times five schedule of BBR3464, a novel cationic triplatinum complex

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12 December 2020

Conformation, recognition by high mobility group domain proteins, and nucleotide excision repair of DNA intrastrand cross-links of novel antitumor trinuclear platinum complex BBR3464

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12 December 2020

Analysis of events associated with cell cycle arrest at G2 phase and cell death induced by cisplatin

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12 December 2020

A combined assay of cell viability and in vitro cytotoxicity with a highly water-soluble tetrazolium salt, neutral red and crystal violet

1 reference

12 December 2020

DNA modifications by a novel bifunctional trinuclear platinum phase I anticancer agent

1 reference

12 December 2020

10.1215/15228517-2006-004

Identifiers

DOI

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28 January 2020

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28 January 2020

PubMed publication ID

16723633

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