ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53. (Q40753388)

23 September 2017

ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53. (English)

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23 September 2017

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3

Atsushi Hirao

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23 September 2017

Damu Tang

1

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23 September 2017

Dongcheng Wu

2

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23 September 2017

Jill M Lahti

4

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23 September 2017

Lieqi Liu

5

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23 September 2017

Brie Mazza

6

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23 September 2017

Vincent J Kidd

7

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23 September 2017

Tak W Mak

8

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23 September 2017

Alistair J Ingram

9

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23 September 2017

language of work or name

English

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publication date

30 January 2002

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Journal of Biological Chemistry

23 September 2017

8

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based on heuristic

inferred from page(s)

published in

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23 September 2017

277

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23 September 2017

12710-12717

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23 September 2017

15

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p53 is required for radiation-induced apoptosis in mouse thymocytes

23 September 2017

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https://api.crossref.org/works/10.1074%2FJBC.M111598200

p53 sends nucleotides to repair DNA.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M111598200

A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

21 January 2018

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The DNA damage response: putting checkpoints in perspective

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M111598200

Checkpoints: How to activate p53

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M111598200

Mdm2 promotes the rapid degradation of p53

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M111598200

Regulation of p53 stability by Mdm2

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M111598200

Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M111598200

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M111598200

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

JNK targets p53 ubiquitination and degradation in nonstressed cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M111598200

p38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M111598200

Making new connections: role of ERK/MAP kinase signaling in neuronal plasticity

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M111598200

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

Ras promotes cell survival in Drosophila by downregulating hid expression

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M111598200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

Signal transduction. How receptors turn Ras on.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M111598200

The 3Rs of life: Ras, Raf and growth regulation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M111598200

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

Effect of extracellular signal-regulated kinase on p53 accumulation in response to cisplatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

Requirement for ERK activation in cisplatin-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

Caspase-8 activation and bid cleavage contribute to MCF7 cellular execution in a caspase-3-dependent manner during staurosporine-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

Akt is activated in response to an apoptotic signal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

Cleavage of DFF-45/ICAD by multiple caspases is essential for its function during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

Etoposide (VP-16-213). Current status of an active anticancer drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

Purification and characterization of ATM from human placenta. A manganese-dependent, wortmannin-sensitive serine/threonine protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

Genetic instabilities in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

Lessons from hereditary colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

Radiation, DNA damage and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

p53, the cellular gatekeeper for growth and division

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

E1A signaling to p53 involves the p19(ARF) tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

Cycloheximide-induced T-cell death is mediated by a Fas-associated death domain-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111598200

21 January 2018

Identifiers

DOI

10.1074/JBC.M111598200

1 reference

23 September 2017

1 reference