Interference of transcriptional activation by the antineoplastic drug ecteinascidin-743. (Q35802653)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10841573%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

title

Interference of transcriptional activation by the antineoplastic drug ecteinascidin-743 (English)

1 reference

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7 November 2019

2

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7 November 2019

Massimo Broggini

3

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7 November 2019

Maurizio D'Incalci

5

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7 November 2019

author name string

M Minuzzo

1

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7 November 2019

G Faircloth

4

1 reference

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7 November 2019

R Mantovani

6

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7 November 2019

language of work or name

English

0 references

publication date

1 June 2000

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10841573%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

7 November 2019

published in

1 reference

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7 November 2019

volume

97

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7 November 2019

issue

12

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7 November 2019

page(s)

6780-6784

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describes a project that uses

7 November 2019

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC18737/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Poisoning of human DNA topoisomerase I by ecteinascidin 743, an anticancer drug that selectively alkylates DNA in the minor groove

27 July 2018

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Phthalascidin, a synthetic antitumor agent with potency and mode of action comparable to ecteinascidin 743.

27 July 2018

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The cyclin B2 promoter depends on NF-Y, a trimer whose CCAAT-binding activity is cell-cycle regulated

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Xenopus NF-Y pre-sets chromatin to potentiate p300 and acetylation-responsive transcription from the Xenopus hsp70 promoter in vivo

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Taxane-mediated gene induction is independent of microtubule stabilization: induction of transcription regulators and enzymes that modulate inflammation and apoptosis

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How can we use our growing understanding of gene transcription to discover effective new medicines?

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Identification of tumor-specific paclitaxel (Taxol)-responsive regulatory elements in the interleukin-8 promoter

27 July 2018

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Cell-cycle regulation of gene expression by transcriptional repression.

27 July 2018

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DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata

27 July 2018

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Heat shock transcription factors: structure and regulation

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CCAAT-box binding protein NF-Y (CBF, CP1) recognizes the minor groove and distorts DNA.

27 July 2018

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DNA sequence-specific adenine alkylation by the novel antitumor drug tallimustine (FCE 24517), a benzoyl nitrogen mustard derivative of distamycin

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Methylation-associated Transcriptional Silencing of the Major Histocompatibility Complex-linked hsp70 Genes in Mouse Cell Lines

27 July 2018

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Doxorubicin-induced Id2A gene transcription is targeted at an activating transcription factor/cyclic AMP response element motif through novel mechanisms involving protein kinases distinct from protein kinase C and protein kinase A

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Role of chromatin and Xenopus laevis heat shock transcription factor in regulation of transcription from the X. laevis hsp70 promoter in vivo

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25 September 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/10841573

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Molecular and crystal structures of ecteinascidins: potent antitumor compounds from the Caribbean tunicate Ecteinascidia turbinata

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10841573

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.97.12.6780

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10841573%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10841573%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

1 reference