SKI-606, an Src inhibitor, reduces tumor growth, invasion, and distant metastasis in a mouse model of thyroid cancer (Q35803670)

10 August 2017

SKI-606, an Src inhibitor, reduces tumor growth, invasion, and distant metastasis in a mouse model of thyroid cancer (English)

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10 August 2017

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ChEBI release 2020-05-28

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Won Gu Kim

1

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10 August 2017

Celine J Guigon

2

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10 August 2017

Laura Fozzatti

3

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10 August 2017

Jeong Won Park

4

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10 August 2017

Changxue Lu

5

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10 August 2017

Mark C Willingham

6

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10 August 2017

Sheue-yann Cheng

7

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10 August 2017

language of work or name

English

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publication date

23 January 2012

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10 August 2017

Clinical Cancer Research

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10 August 2017

18

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10 August 2017

5

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10 August 2017

1281-1290

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describes a project that uses

10 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3294177/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Advances in targeting SRC in the treatment of breast cancer and other solid malignancies

11 July 2018

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Novel dual Src/Abl inhibitors for hematologic and solid malignancies

11 July 2018

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SKI-606 (Bosutinib) blocks prostate cancer invasion, growth, and metastasis in vitro and in vivo through regulation of genes involved in cancer growth and skeletal metastasis.

11 July 2018

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Inhibition of mTORC1 signaling reduces tumor growth but does not prevent cancer progression in a mouse model of thyroid cancer.

11 July 2018

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Growth activation alone is not sufficient to cause metastatic thyroid cancer in a mouse model of follicular thyroid carcinoma

11 July 2018

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Src signaling in cancer invasion

11 July 2018

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The BRAFV600E oncogene induces transforming growth factor beta secretion leading to sodium iodide symporter repression and increased malignancy in thyroid cancer

11 July 2018

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Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer

11 July 2018

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Src kinases as therapeutic targets for cancer

11 July 2018

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Characterisation of fibronectin-mediated FAK signalling pathways in lung cancer cell migration and invasion

11 July 2018

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Efficacy and pharmacodynamic effects of bosutinib (SKI-606), a Src/Abl inhibitor, in freshly generated human pancreas cancer xenografts

11 July 2018

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Reorganization of the integrin alpha2 subunit controls cell adhesion and cancer cell invasion in prostate cancer

11 July 2018

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International patterns and trends in thyroid cancer incidence, 1973-2002

11 July 2018

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PTEN deficiency accelerates tumour progression in a mouse model of thyroid cancer

11 July 2018

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Targeting Src in breast cancer

11 July 2018

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SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells

11 July 2018

1 reference

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A Src/Abl kinase inhibitor, SKI-606, blocks breast cancer invasion, growth, and metastasis in vitro and in vivo

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294177

European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium

11 July 2018

1 reference

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Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: benefits and limits of radioiodine therapy.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294177

SKI-606 decreases growth and motility of colorectal cancer cells by preventing pp60(c-Src)-dependent tyrosine phosphorylation of beta-catenin and its nuclear signaling

11 July 2018

1 reference

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An unliganded thyroid hormone beta receptor activates the cyclin D1/cyclin-dependent kinase/retinoblastoma/E2F pathway and induces pituitary tumorigenesis

11 July 2018

1 reference

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Increased expression of focal adhesion kinase in thyroid cancer: immunohistochemical study

11 July 2018

1 reference

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Differential regulation of cell motility and invasion by FAK

11 July 2018

1 reference

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Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions

11 July 2018

1 reference

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Mice with a targeted mutation in the thyroid hormone beta receptor gene exhibit impaired growth and resistance to thyroid hormone

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294177

Role of c-Src tyrosine kinase in EGF-induced mitogenesis.

11 July 2018

1 reference

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Focal adhesion kinase as a marker of invasive potential in differentiated human thyroid cancer

11 July 2018

1 reference

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Cadherin cell adhesion receptors as a morphogenetic regulator

11 July 2018

1 reference

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SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models

11 July 2018

1 reference

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Alterations in genomic profiles during tumor progression in a mouse model of follicular thyroid carcinoma.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294177

SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294177

Clinical significance of E-cadherin as a prognostic marker in thyroid carcinomas

25 September 2018

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12 December 2020

Prognostic value of E-cadherin expression in thyroid follicular carcinoma

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12 December 2020

AKT activation promotes metastasis in a mouse model of follicular thyroid carcinoma

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12 December 2020

Hypothyroidism in patients with metastatic renal cell carcinoma treated with sunitinib

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12 December 2020

Evaluation of FAK and Src expression in human benign and malignant thyroid lesions

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12 December 2020

10.1158/1078-0432.CCR-11-2892

Identifiers

DOI

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10 August 2017

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10 August 2017

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