Mapping early conformational changes in alphaIIb and beta3 during biogenesis reveals a potential mechanism for alphaIIbbeta3 adopting its bent conformation (Q35804502)

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scientific article published on 5 January 2007

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English	Mapping early conformational changes in alphaIIb and beta3 during biogenesis reveals a potential mechanism for alphaIIbbeta3 adopting its bent conformation	scientific article published on 5 January 2007

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scholarly article

1 reference

Europe PubMed Central

10 August 2017

Mapping early conformational changes in alphaIIb and beta3 during biogenesis reveals a potential mechanism for alphaIIbbeta3 adopting its bent conformation (English)

1 reference

Europe PubMed Central

10 August 2017

author name string

W Beau Mitchell

1

1 reference

Europe PubMed Central

10 August 2017

Jihong Li

2

1 reference

Europe PubMed Central

10 August 2017

Marta Murcia

3

1 reference

Europe PubMed Central

10 August 2017

Nathalie Valentin

4

1 reference

Europe PubMed Central

10 August 2017

Peter J Newman

5

1 reference

Europe PubMed Central

10 August 2017

Barry S Coller

6

1 reference

Europe PubMed Central

10 August 2017

language of work or name

0 references

publication date

5 January 2007

1 reference

Europe PubMed Central

10 August 2017

1 reference

Europe PubMed Central

10 August 2017

109

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Europe PubMed Central

10 August 2017

9

1 reference

Europe PubMed Central

10 August 2017

3725-3732

1 reference

Europe PubMed Central

10 August 2017

Drug insight: using monoclonal antibodies to treat multiple sclerosis

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Beyond lectins: the calnexin/calreticulin chaperone system of the endoplasmic reticulum

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alphaIIbbeta3 biogenesis is controlled by engagement of alphaIIb in the calnexin cycle via the N15-linked glycan

1 reference

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Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics

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A novel adaptation of the integrin PSI domain revealed from its crystal structure

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Integrin beta3 regions controlling binding of murine mAb 7E3: implications for the mechanism of integrin alphaIIbbeta3 activation

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Protein structure prediction and analysis using the Robetta server.

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Two novel mutations in the alpha IIb calcium-binding domains identify hydrophobic regions essential for alpha IIbbeta 3 biogenesis

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1 reference

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Integrin activation and structural rearrangement

1 reference

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Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand

1 reference

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Crystal structure of the extracellular segment of integrin alpha Vbeta3

1 reference

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Anti-GPIIb/IIIa drugs: current strategies and future directions

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Modeling of loops in protein structures

1 reference

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11 July 2018

A recombinant soluble form of the integrin alpha IIb beta 3 (GPIIb-IIIa) assumes an active, ligand-binding conformation and is recognized by GPIIb-IIIa-specific monoclonal, allo-, auto-, and drug-dependent platelet antibodies

1 reference

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Platelet GPIIb/IIIa antagonists: the first anti-integrin receptor therapeutics.

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Assembly of protein tertiary structures from fragments with similar local sequences using simulated annealing and Bayesian scoring functions

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Folding of the beta-propeller domain of the integrin alphaL subunit is independent of the I domain and dependent on the beta2 subunit

1 reference

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Folding of the conserved domain but not of flanking regions in the integrin beta2 subunit requires association with the alpha subunit

1 reference

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Long range propagation of conformational changes in integrin alpha IIb beta 3.

1 reference

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Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta 3 subunit

1 reference

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A murine monoclonal antibody that completely blocks the binding of fibrinogen to platelets produces a thrombasthenic-like state in normal platelets and binds to glycoproteins IIb and/or IIIa

1 reference

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Platelet-collagen adhesion: inhibition by a monoclonal antibody that binds glycoprotein IIb.

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Quantitation of membrane glycoprotein IIIa on intact human platelets using the monoclonal antibody, AP-3.

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Biosynthesis and processing of platelet GPIIb-IIIa in human megakaryocytes

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Biogenesis of the platelet receptor for fibrinogen: evidence for separate precursors for glycoproteins IIb and IIIa

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A new murine monoclonal antibody reports an activation-dependent change in the conformation and/or microenvironment of the platelet glycoprotein IIb/IIIa complex

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Localization of internal pools of membrane glycoproteins involved in platelet adhesive responses

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Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers.

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Agonist-specific structural rearrangements of integrin alpha IIbbeta 3. Confirmation of the bent conformation in platelets at rest and after activation

1 reference

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Calcium cation regulation of glycoprotein IIb-IIIa complex formation in platelet plasma membranes

1 reference

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Occupancy of an adhesive glycoprotein receptor modulates expression of an antigenic site involved in cell adhesion

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Isolation and structural characterization of the polypeptide subunits of membrane glycoprotein IIb-IIIa from human platelets

1 reference

https://pubmed.ncbi.nlm.nih.gov/17209052

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based on heuristic

inferred from PubMed ID database lookup

Calcium regulation of glycoproteins IIb and IIIa in human platelet membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17209052

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the binding of an alloimmune and two murine monoclonal antibodies to the platelet glycoprotein IIb-IIIa complex receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17209052

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based on heuristic

inferred from PubMed ID database lookup

Resting platelets contain a substantial centrally located pool of glycoprotein IIb-IIIa complex which may be accessible to some but not other extracellular proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/17209052

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based on heuristic

inferred from PubMed ID database lookup

The in vitro synthesis of polypeptides for the platelet membrane glycoproteins IIb and IIIa

1 reference

https://pubmed.ncbi.nlm.nih.gov/17209052

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosynthesis and assembly of platelet GPIIb-IIIa in human megakaryocytes: evidence that assembly between pro-GPIIb and GPIIIa is a prerequisite for expression of the complex on the cell surface

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Further characterization of the loop structure of platelet glycoprotein IIIa: partial mapping of functionally significant glycoprotein IIIa epitopes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17209052

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based on heuristic

inferred from PubMed ID database lookup

Activation of the fibrinogen binding site on platelets isolated from a patient with the Strasbourg I variant of Glanzmann's thrombasthenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17209052

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based on heuristic

inferred from PubMed ID database lookup

Partial inhibition of platelet aggregation and fibrinogen binding by a murine monoclonal antibody to GPIIIa: requirement for antibody bivalency

1 reference

https://pubmed.ncbi.nlm.nih.gov/17209052

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based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/17209052

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based on heuristic

inferred from PubMed ID database lookup

Association between ligand-induced conformational changes of integrin IIbbeta3 and IIbbeta3-mediated intracellular Ca2+ signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/17209052

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1182/BLOOD-2006-11-058420

1 reference

Europe PubMed Central

10 August 2017

1 reference

Europe PubMed Central

10 August 2017

1 reference

Europe PubMed Central

10 August 2017

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