Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2). (Q35814421)

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scientific article published on 24 February 2012

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English	Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).	scientific article published on 24 February 2012

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24 January 2020

Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2) (English)

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24 January 2020

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Plasmodium falciparum

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Chandrakala Pidathala

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24 January 2020

Richard K Amewu

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Sitthivut Charoensutthivarakul

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Ashley J Warman

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Giancarlo Biagini

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Peter Gibbons

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W David Hong

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Raman Sharma

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Abhishek Srivastava

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Lee Taylor

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Alasdair Hill

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Nicholas E Fisher

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Paul M O'Neill

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24 February 2012

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24 January 2020

Journal of Medicinal Chemistry

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24 January 2020

1831-1843

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24 January 2020

Lipophilicity in drug discovery

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1 reference

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1 reference

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1 reference

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Chapter 17 Type II NADH: quinone oxidoreductases of Plasmodium falciparum and Mycobacterium tuberculosis kinetic and high-throughput assays.

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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10.1021/JM201179H

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24 January 2020

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24 January 2020

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24 January 2020

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