Human cytomegalovirus UL40 signal peptide regulates cell surface expression of the NK cell ligands HLA-E and gpUL18 (Q35828380)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22345649%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

title

Human cytomegalovirus UL40 signal peptide regulates cell surface expression of the NK cell ligands HLA-E and gpUL18 (English)

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23 January 2020

5

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23 January 2020

Virginie Prod'Homme

1

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23 January 2020

Marius K Lemberg

4

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23 January 2020

Brian P McSharry

6

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23 January 2020

Eddie C. Wang

7

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23 January 2020

Veronique Braud

11

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Gavin W G Wilkinson

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23 January 2020

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Andrew J Davison

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23 January 2020

author name string

Peter Tomasec

2

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23 January 2020

Charles Cunningham

3

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23 January 2020

Simone Cuff

8

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23 January 2020

Bruno Martoglio

9

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23 January 2020

language of work or name

English

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publication date

15 February 2012

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23 January 2020

published in

Journal of Immunology

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23 January 2020

volume

188

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23 January 2020

issue

6

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23 January 2020

page(s)

2794-2804

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Reconstruction of the complete human cytomegalovirus genome in a BAC reveals RL13 to be a potent inhibitor of replication.

23 January 2020

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11 July 2018

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11 July 2018

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Structural elements underlying the high binding affinity of human cytomegalovirus UL18 to leukocyte immunoglobulin-like receptor-1

11 July 2018

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The human cytomegalovirus MHC class I homolog UL18 inhibits LIR-1+ but activates LIR-1- NK cells.

11 July 2018

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Purification and HPLC-MS analysis of a naturally processed HCMV-derived peptide isolated from the HEK-293T/HLA-E+/Ul40+ cell transfectants and presented at the cell surface in the context of HLA-E.

11 July 2018

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Expansion of CD94/NKG2C+ NK cells in response to human cytomegalovirus-infected fibroblasts.

11 July 2018

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Characterization of a highly glycosylated form of the human cytomegalovirus HLA class I homologue gpUL18

11 July 2018

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The HLA-A2 restricted T cell epitope HCV core 35-44 stabilizes HLA-E expression and inhibits cytolysis mediated by natural killer cells

11 July 2018

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The dynamic life of natural killer cells

11 July 2018

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HLA-E-restricted recognition of cytomegalovirus-derived peptides by human CD8+ cytolytic T lymphocytes

11 July 2018

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Crystal structure of HLA-A2 bound to LIR-1, a host and viral major histocompatibility complex receptor

11 July 2018

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11 July 2018

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11 July 2018

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Immunomodulation by cytomegaloviruses: manipulative strategies beyond evasion

11 July 2018

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Identification of signal peptide peptidase, a presenilin-type aspartic protease

11 July 2018

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UL40-mediated NK evasion during productive infection with human cytomegalovirus.

11 July 2018

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Intramembrane proteolysis of signal peptides: an essential step in the generation of HLA-E epitopes

11 July 2018

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Human telomerase reverse transcriptase-immortalized MRC-5 and HCA2 human fibroblasts are fully permissive for human cytomegalovirus

11 July 2018

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Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor

11 July 2018

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The structure and stability of an HLA-A*0201/octameric tax peptide complex with an empty conserved peptide-N-terminal binding site

11 July 2018

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Cutting edge: the human cytomegalovirus UL40 gene product contains a ligand for HLA-E and prevents NK cell-mediated lysis

11 July 2018

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Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40.

11 July 2018

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The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral homolog UL18.

11 July 2018

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Association of a syndrome resembling Wegener's granulomatosis with low surface expression of HLA class-I molecules

11 July 2018

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HLA-E surface expression depends on binding of TAP-dependent peptides derived from certain HLA class I signal sequences

11 July 2018

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HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C

11 July 2018

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Recognition of human histocompatibility leukocyte antigen (HLA)-E complexed with HLA class I signal sequence-derived peptides by CD94/NKG2 confers protection from natural killer cell-mediated lysis

11 July 2018

1 reference

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TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide

11 July 2018

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Characterization of a murine cytomegalovirus class I major histocompatibility complex (MHC) homolog: comparison to MHC molecules and to the human cytomegalovirus MHC homolog.

11 July 2018

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A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules

11 July 2018

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The human major histocompatibility complex class Ib molecule HLA-E binds signal sequence-derived peptides with primary anchor residues at positions 2 and 9

11 July 2018

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Protein insertion into the endoplasmic reticulum of permeabilized cells

11 July 2018

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Ribosome-SRP-signal sequence interactions. The relay helix hypothesis

11 July 2018

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Predicting the orientation of eukaryotic membrane-spanning proteins

11 July 2018

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A complex between the MHC class I homologue encoded by human cytomegalovirus and beta 2 microglobulin

11 July 2018

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HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides

11 July 2018

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HLA-A2.1-associated peptides from a mutant cell line: a second pathway of antigen presentation

11 July 2018

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Construction and characterization of a human cytomegalovirus mutant with the UL18 (class I homolog) gene deleted

11 July 2018

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The UL16 gene of human cytomegalovirus encodes a glycoprotein that is dispensable for growth in vitro

11 July 2018

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Constitutive and enhanced expression from the CMV major IE promoter in a defective adenovirus vector

11 July 2018

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UL40 human cytomegalovirus variability evolution patterns over time in renal transplant recipients.

11 July 2018

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Adenovirus E3/19K promotes evasion of NK cell recognition by intracellular sequestration of the NKG2D ligands major histocompatibility complex class I chain-related proteins A and B.

24 September 2018

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The crystal structure of H-2D(b) complexed with a partial peptide epitope suggests a major histocompatibility complex class I assembly intermediate.

24 September 2018

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Imprint of human cytomegalovirus infection on the NK cell receptor repertoire

24 September 2018

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Genetic content of wild-type human cytomegalovirus.

24 September 2018

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Analysis of polypeptides by sodium dodecyl sulfate-polyacrylamide gel electrophoresis alongside in vitro-generated reference peptides

24 September 2018

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The MHC class I homolog of human cytomegalovirus is resistant to down-regulation mediated by the unique short region protein (US)2, US3, US6, and US11 gene products.

24 September 2018

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The MHC class I homolog encoded by human cytomegalovirus binds endogenous peptides.

24 September 2018

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NKp46 and DNAM-1 NK-cell receptors drive the response to human cytomegalovirus-infected myeloid dendritic cells overcoming viral immune evasion strategies

24 September 2018

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Synergistic effect of IFN-gamma and human cytomegalovirus protein UL40 in the HLA-E-dependent protection from NK cell-mediated cytotoxicity

6 December 2018

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12 December 2020

Signal sequences: more than just greasy peptides

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12 December 2020

Interactions between NKG2x immunoreceptors and HLA-E ligands display overlapping affinities and thermodynamics

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12 December 2020

HIV-1 infection leads to increased HLA-E expression resulting in impaired function of natural killer cells

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12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.1102068

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22345649%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22345649%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22345649%20AND%20SRC:MED&resulttype=core&format=json