Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation (Q35828643)

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scientific article published on 30 January 2007

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English	Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation	scientific article published on 30 January 2007

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scholarly article

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Europe PubMed Central

PMC publication ID

10 August 2017

Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation (English)

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Europe PubMed Central

PMC publication ID

10 August 2017

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Paul Dent

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Europe PubMed Central

10 August 2017

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Yun Dai

1

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Europe PubMed Central

PMC publication ID

10 August 2017

Payal Khanna

2

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Europe PubMed Central

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10 August 2017

Shuang Chen

3

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Europe PubMed Central

PMC publication ID

10 August 2017

Xin-Yan Pei

4

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Europe PubMed Central

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10 August 2017

Steven Grant

6

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10 August 2017

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publication date

30 January 2007

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Europe PubMed Central

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10 August 2017

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Europe PubMed Central

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10 August 2017

109

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10 August 2017

10

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

4415-4423

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Activation of Ras up-regulates pro-apoptotic BNIP3 in nitric oxide-induced cell death

1 reference

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Dissecting the roles of checkpoint kinase 1/CDC2 and mitogen-activated protein kinase kinase 1/2/extracellular signal-regulated kinase 1/2 in relation to 7-hydroxystaurosporine-induced apoptosis in human multiple myeloma cells

1 reference

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Statin use and cancer risk: an epidemiologic review

1 reference

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Targeting the mitogen-activated protein kinase pathway in the treatment of malignant melanoma

1 reference

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1 reference

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Transient exposure of mammary tumors to PD184352 and UCN-01 causes tumor cell death in vivo and prolonged suppression of tumor regrowth

1 reference

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Therapy insight: Potential of statins for cancer chemoprevention and therapy

1 reference

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1 reference

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HMG-CoA reductase inhibitors (statins) as anticancer drugs (review).

1 reference

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1 reference

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The role of statins in cancer prevention and treatment.

1 reference

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27 July 2018

The farnesyltransferase inhibitor L744832 potentiates UCN-01-induced apoptosis in human multiple myeloma cells

1 reference

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Protein farnesylation: implications for normal physiology, malignant transformation, and cancer therapy

1 reference

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27 July 2018

Effects of statins and farnesyltransferase inhibitors on the development and progression of cancer

1 reference

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1 reference

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27 July 2018

Blocking the Raf/MEK/ERK pathway sensitizes acute myelogenous leukemia cells to lovastatin-induced apoptosis

1 reference

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27 July 2018

In vitro combination treatment with perifosine and UCN-01 demonstrates synergism against prostate (PC-3) and lung (A549) epithelial adenocarcinoma cell lines

1 reference

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Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01.

1 reference

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27 July 2018

The HMG-CoA reductase inhibitor simvastatin overcomes cell adhesion-mediated drug resistance in multiple myeloma by geranylgeranylation of Rho protein and activation of Rho kinase

1 reference

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Small molecule inhibitors targeting cyclin-dependent kinases as anticancer agents

1 reference

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27 July 2018

Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885487

27 July 2018

Farnesyl transferase inhibitors: mechanism of action, translational studies and clinical evaluation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885487

27 July 2018

Targeting RAS signalling pathways in cancer therapy

1 reference

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27 July 2018

Activation of N-ras and K-ras induced by interleukin-6 in a myeloma cell line: implications for disease progression and therapeutic response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885487

27 July 2018

Induction of p202, a modulator of apoptosis, during oncogenic transformation of NIH 3T3 cells by activated H-Ras (Q61L) contributes to cell survival

1 reference

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HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis

1 reference

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Consequences of mevalonate depletion. Differential transcriptional, translational, and post-translational up-regulation of Ras, Rap1a, RhoA, AND RhoB.

1 reference

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1 reference

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1 reference

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1 reference

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Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies?

1 reference

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Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

1 reference

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1 reference

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1 reference

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IL-6 triggers cell growth via the Ras-dependent mitogen-activated protein kinase cascade.

1 reference

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Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

1 reference

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1 reference

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Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain

1 reference

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1 reference

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Recent advances in understanding the antineoplastic mechanisms of farnesyltransferase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885487

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Pharmacodynamic effects of high dose lovastatin in subjects with advanced malignancies

1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885487

24 September 2018

Review of UCN-01 development: a lesson in the importance of clinical pharmacology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885487

24 September 2018

A phase I and pharmacokinetic study of short infusions of UCN-01 in patients with refractory solid tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885487

24 September 2018

Simvastatin inhibits T-cell activation by selectively impairing the function of Ras superfamily GTPases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885487

24 September 2018

Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885487

24 September 2018

Inhibition of protein geranylgeranylation induces apoptosis in myeloma plasma cells by reducing Mcl-1 protein levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885487

24 September 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885487

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885487

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1 reference

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1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885487

24 September 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885487

24 September 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885487

24 September 2018

Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885487

24 September 2018

Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885487

24 September 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885487

24 September 2018

Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885487

24 September 2018

Potentiation of 1-beta-D-arabinofuranosylcytosine-mediated mitochondrial damage and apoptosis in human leukemia cells (U937) overexpressing bcl-2 by the kinase inhibitor 7-hydroxystaurosporine (UCN-01).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885487

24 September 2018

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885487

24 September 2018

Increased sensitivity of acute myeloid leukemias to lovastatin-induced apoptosis: A potential therapeutic approach

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885487

15 November 2018

Different structural requirements within the switch II region of the Ras protein for interactions with specific downstream targets

1 reference

https://pubmed.ncbi.nlm.nih.gov/17264303

12 December 2020

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10.1182/BLOOD-2006-09-047076

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

ResearchGate publication ID

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