V(D)J recombination: how to tame a transposase (Q35830443)

10 August 2017

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title

V(D)J recombination: how to tame a transposase (English)

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10 August 2017

Vicky L Brandt

1

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10 August 2017

David B Roth

series ordinal

2

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10 August 2017

publication date

1 August 2004

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10 August 2017

published in

Immunological Reviews

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10 August 2017

volume

200

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10 August 2017

page(s)

249-260

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Restraining the V(D)J recombinase

10 August 2017

cites work

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations

21 January 2018

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Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system

21 January 2018

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The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

Separation-of-function mutants reveal critical roles for RAG2 in both the cleavage and joining steps of V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

New insights into V(D)J recombination and its role in the evolution of the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

From lymphocytes to sharks: V(D)J recombinase moves to the germline

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

Ku86 is not required for protection of signal ends or for formation of nonstandard V(D)J recombination products

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

V(D)J recombination intermediates and non-standard products in XRCC4-deficient cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

Analysis of variable (diversity) joining recombination in DNAdependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

Rejoining of DNA by the RAG1 and RAG2 proteins.

21 January 2018

1 reference

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Roles of the "dispensable" portions of RAG-1 and RAG-2 in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

Residues critical for retroviral integrative recombination in a region that is highly conserved among retroviral/retrotransposon integrases and bacterial insertion sequence transposases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

DNA transposition: from a black box to a color monitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase

21 January 2018

1 reference

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High-resolution structure of the catalytic domain of avian sarcoma virus integrase

21 January 2018

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Three new structures of the core domain of HIV-1 integrase: an active site that binds magnesium

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: high level of similarity of the active site with other viral integrases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

Two-metal active site binding of a Tn5 transposase synaptic complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

V(D)J Recombination and the Evolution of the Adaptive Immune System

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

Intermediates in V(D)J recombination: a stable RAG1/2 complex sequesters cleaved RSS ends.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

The RAG proteins in V(D)J recombination: more than just a nuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

V(D)J recombination: signal and coding joint resolution are uncoupled and depend on parallel synapsis of the sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

RAG transposase can capture and commit to target DNA before or after donor cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

The Tn10 synaptic complex can capture a target DNA only after transposon excision.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

A RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

A RAG-1/RAG-2 tetramer supports 12/23-regulated synapsis, cleavage, and transposition of V(D)J recombination signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

Assembly of the RAG1/RAG2 synaptic complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

Targeted transposition by the V(D)J recombinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

The C-terminal portion of RAG2 protects against transposition in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

Full-length RAG-2, and Not Full-length RAG-1, Specifically Suppresses RAG-mediated Transposition but Not Hybrid Joint Formation or Disintegration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

Regulation of RAG1/RAG2-mediated transposition by GTP and the C-terminal region of RAG2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

Target DNA structure plays a critical role in Tn7 transposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

Recognition of triple-helical DNA structures by transposon Tn7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

Selective recognition of pyrimidine motif triplexes by a protein encoded by the bacterial transposon Tn7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

In vivo transposition mediated by V(D)J recombinase in human T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

Intermolecular V(D)J recombination is prohibited specifically at the joining step

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

Increased accumulation of hybrid V(D)J joins in cells expressing truncated versus full-length RAGs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

Inversions produced during V(D)J rearrangement at IgH, the immunoglobulin heavy-chain locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

Abnormal deletions in the T-cell receptor delta locus of mouse thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00161.X

10.1111/J.0105-2896.2004.00161.X

21 January 2018

Identifiers

DOI

1 reference

10 August 2017

1 reference