Separation-of-function mutants reveal critical roles for RAG2 in both the cleavage and joining steps of V(D)J recombination (Q42642005)

4 November 2017

title

Separation-of-function mutants reveal critical roles for RAG2 in both the cleavage and joining steps of V(D)J recombination (English)

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4 November 2017

Qiu JX

1

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4 November 2017

Kale SB

series ordinal

2

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4 November 2017

Yarnell Schultz H

series ordinal

3

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4 November 2017

Roth DB

series ordinal

4

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4 November 2017

publication date

1 January 2001

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4 November 2017

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4 November 2017

volume

7

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4 November 2017

issue

1

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4 November 2017

page(s)

77-87

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Postcleavage sequence specificity in V(D)J recombination

4 November 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

Hairpin coding end opening is mediated by RAG1 and RAG2 proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

V(D)J recombination in Ku86-deficient mice: distinct effects on coding, signal, and hybrid joint formation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

The three chemical steps of Tn10/IS10 transposition involve repeated utilization of a single active site

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

Analysis of regions of RAG-2 important for V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

The RAG proteins and V(D)J recombination: complexes, ends, and transposition

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

Antigen receptor gene rearrangement

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

V(D)J recombination intermediates and non-standard products in XRCC4-deficient cells

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

Wild-type V(D)J recombination in scid pre-B cells

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

Hairpin opening by single-strand-specific nucleases

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

Conditional RAG-1 mutants block the hairpin formation step of V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

T cell receptor gamma and delta gene junctional sequences in SCID mice: excessive P nucleotide insertion

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

Mutational analysis of the Mu transposase. Contributions of two distinct regions of domain II to recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

Junctional sequences of T cell receptor gamma delta genes: implications for gamma delta T cell lineages and for a novel intermediate of V-(D)-J joining.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

Coding joint formation in a cell-free V(D)J recombination system

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

P nucleotide insertions and the resolution of hairpin DNA structures in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

Novel strand exchanges in V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

Rejoining of DNA by the RAG1 and RAG2 proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

High frequency of normal DJH joints in B cell progenitors in severe combined immunodeficiency mice

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

Cell-free V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

Definition of a core region of RAG-2 that is functional in V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

The RAG1/RAG2 complex constitutes a 3' flap endonuclease: implications for junctional diversity in V(D)J and transpositional recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

V(D)J recombination: modulation of RAG1 and RAG2 cleavage activity on 12/23 substrates by whole cell extract and DNA-bending proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

Coding joint formation of endogenous T cell receptor genes in lymphoid cells from scid mice: unusual P-nucleotide additions in VJ-coding joints

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

Joining-deficient RAG1 mutants block V(D)J recombination in vivo and hairpin opening in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

Severe combined immunodeficiency (SCID) in man: B cell-negative (B-) SCID patients exhibit an irregular recombination pattern at the JH locus

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

DNA hairpin opening mediated by the RAG1 and RAG2 proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

The 12/23 rule is enforced at the cleavage step of V(D)J recombination in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

Initiation of V(D)J recombination in vivo: role of recombination signal sequences in formation of single and paired double-strand breaks

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

V(D)J recombination signal recognition: distinct, overlapping DNA-protein contacts in complexes containing RAG1 with and without RAG2.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

RAG-2 promotes heptamer occupancy by RAG-1 in the assembly of a V(D)J initiation complex

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

Impairment of V(D)J recombination in double-strand break repair mutants

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900156-3

7 January 2021

10.1016/S1097-2765(01)00156-3

Identifiers

DOI

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4 November 2017

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