Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation. (Q35848377)

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13 January 2020

title

Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation (English)

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13 January 2020

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Tracy I George

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Michael C. Heinrich

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Stephen J Galli

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Len Neckers

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author name string

Jason Gotlib

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Caroline Berubé

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Joseph D Growney

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Christopher Williams

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Tomohiro Kajiguchi

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Jia Ruan

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Stan L Lilleberg

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Jeffrey A Durocher

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Jack H Lichy

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Yanfeng Wang

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Pamela S Cohen

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Daniel A Arber

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D Gary Gilliland

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Steven E Coutré

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language of work or name

English

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publication date

21 June 2005

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volume

106

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issue

8

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13 January 2020

page(s)

2865-2870

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Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412.

13 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895309

PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder

11 July 2018

1 reference

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Response to therapy with interferon alpha-2b and prednisolone in aggressive systemic mastocytosis: report of five cases and review of the literature.

11 July 2018

1 reference

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17-Allylamino-17-demethoxygeldanamycin (17-AAG) is effective in down-regulating mutated, constitutively activated KIT protein in human mast cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895309

Diagnosis and treatment of systemic mastocytosis: state of the art.

11 July 2018

1 reference

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PKC412 overcomes resistance to imatinib in a murine model of FIP1L1-PDGFRα-induced myeloproliferative disease.

11 July 2018

1 reference

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Aggressive systemic mastocytosis and related mast cell disorders: current treatment options and proposed response criteria

11 July 2018

1 reference

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Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412.

11 July 2018

1 reference

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The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895309

The complexity of KIT gene mutations and chromosome rearrangements and their clinical correlation in gastrointestinal stromal (pacemaker cell) tumors

11 July 2018

1 reference

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Signal transducer and activator of transcription 3 activation is required for Asp(816) mutant c-Kit-mediated cytokine-independent survival and proliferation in human leukemia cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895309

Phase I and pharmacokinetic study of PKC412, an inhibitor of protein kinase C.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895309

Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895309

The kit ligand, stem cell factor

11 July 2018

1 reference

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Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder

11 July 2018

1 reference

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Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412.

11 July 2018

1 reference

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Cladribine therapy for systemic mastocytosis.

24 September 2018

1 reference

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Imatinib for systemic mast-cell disease

24 September 2018

1 reference

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Effects of tyrosine kinase inhibitor STI571 on human mast cells bearing wild-type or mutated c-kit

24 September 2018

1 reference

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Signal transduction by several KIT juxtamembrane domain mutations

24 September 2018

1 reference

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Treatment of adult systemic mastocytosis with interferon-alpha: results of a multicentre phase II trial on 20 patients

24 September 2018

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Serum tryptase measurements in patients with myelodysplastic syndromes

24 September 2018

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PKC412--a protein kinase inhibitor with a broad therapeutic potential

24 September 2018

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12 December 2020

High sensitivity scanning of colorectal tumors and matched plasma DNA for mutations in APC, TP53, K-RAS, and BRAF genes with a novel DHPLC fluorescence detection platform

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12 December 2020

Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm

1 reference

12 December 2020

FLT3 Inhibitors in the Treatment of AML

1 reference

12 December 2020

10.1182/BLOOD-2005-04-1568

Identifiers

DOI

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13 January 2020

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13 January 2020

PubMed publication ID

15972446

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