Versatile pathway-centric approach based on high-throughput sequencing to anticancer drug discovery (Q35849603)

10 August 2017

Versatile pathway-centric approach based on high-throughput sequencing to anticancer drug discovery (English)

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high-throughput sequencing

10 August 2017

1 reference

1 reference

Hairi Li

1

1 reference

10 August 2017

Hongyan Zhou

2

1 reference

10 August 2017

Dong Wang

3

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10 August 2017

Jinsong Qiu

4

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10 August 2017

Yu Zhou

5

1 reference

10 August 2017

Xiangqiang Li

6

1 reference

10 August 2017

Michael G Rosenfeld

7

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10 August 2017

Sheng Ding

8

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10 August 2017

Xiang-Dong Fu

9

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10 August 2017

language of work or name

English

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publication date

6 March 2012

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10 August 2017

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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10 August 2017

109

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10 August 2017

12

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10 August 2017

4609-4614

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RASL-seq for massively parallel and quantitative analysis of gene expression

10 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311343

A novel two-stage, transdisciplinary study identifies digoxin as a possible drug for prostate cancer treatment

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311343

How were new medicines discovered?

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311343

Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311343

A multiplex RNA-seq strategy to profile poly(A+) RNA: application to analysis of transcription response and 3' end formation.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311343

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311343

Cardiac glycosides are potent inhibitors of interferon-β gene expression

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311343

Pharmacological targeting of constitutively active truncated androgen receptor by nigericin and suppression of hormone-refractory prostate cancer cell growth.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311343

Differential androgen receptor signals in different cells explain why androgen-deprivation therapy of prostate cancer fails

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311343

How to improve R&D productivity: the pharmaceutical industry's grand challenge

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311343

Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311343

Identification of selective inhibitors of cancer stem cells by high-throughput screening

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311343

Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311343

Identification of AML1-ETO modulators by chemical genomics

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311343

Non-competitive androgen receptor inhibition in vitro and in vivo.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311343

A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311343

Determination of tag density required for digital transcriptome analysis: application to an androgen-sensitive prostate cancer model

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311343

Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311343

Novel therapeutic applications of cardiac glycosides

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311343

Evidence for calpain-mediated androgen receptor cleavage as a mechanism for androgen independence

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311343

Rethinking target discovery in polygenic diseases.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311343

Drugs, their targets and the nature and number of drug targets

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311343

Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311343

Two-dimensional transcriptome profiling: identification of messenger RNA isoform signatures in prostate cancer from archived paraffin-embedded cancer specimens

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311343

Linking tumor cell cytotoxicity to mechanism of drug action: an integrated analysis of gene expression, small-molecule screening and structural databases

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311343

A versatile assay for high-throughput gene expression profiling on universal array matrices

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311343

Molecular determinants of resistance to antiandrogen therapy

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311343

Effects of bufalin and cinobufagin on the proliferation of androgen dependent and independent prostate cancer cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311343

Profiling alternative splicing on fiber-optic arrays

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311343

Antiandrogens in prostate cancer

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311343

Essential role for estrogen receptor beta in stromal-epithelial regulation of prostatic hyperplasia.

11 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1200305109

A cellular conformation-based screen for androgen receptor inhibitors

21 January 2018

1 reference

PubMed

12 December 2020

Cardiac glycosides stimulate Ca2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells

1 reference

PubMed

12 December 2020

Gene expression-based high-throughput screening(GE-HTS) and application to leukemia differentiation

1 reference

PubMed

12 December 2020

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1200305109

1 reference

10 August 2017

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10 August 2017

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