Pathogenic factors in vascular dementia and Alzheimer's disease. Multiple actions of heparin that probably are beneficial (Q35852208)

10 August 2017

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title

Pathogenic factors in vascular dementia and Alzheimer's disease. Multiple actions of heparin that probably are beneficial (English)

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10 August 2017

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Hyman Engelberg

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PubMed ID

15286460

10 August 2017

language of work or name

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30 July 2004

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Dementia and Geriatric Cognitive Disorders

10 August 2017

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10 August 2017

18

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10 August 2017

3-4

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10 August 2017

278-298

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Diagnosis, management, and treatment of Alzheimer disease: a guide for the internist

10 August 2017

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A population-based study on the incidence of dementia disorders between 85 and 88 years of age.

21 January 2018

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From mechanisms to drugs in Alzheimer's disease.

21 January 2018

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Midlife cardiovascular risk factors, ApoE, and cognitive decline in elderly male twins.

21 January 2018

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The role of APOE epsilon4 in modulating effects of other risk factors for cognitive decline in elderly persons

21 January 2018

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Cerebrovascular disease and threshold for dementia in the early stages of Alzheimer's disease.

21 January 2018

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Untangling vascular dementia.

21 January 2018

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Cerebral perfusion SPET correlated with Braak pathological stage in Alzheimer's disease.

21 January 2018

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Molecular biology of Alzheimer's disease

21 January 2018

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Platelet activation in Alzheimer disease.

21 January 2018

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Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor

21 January 2018

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Cysteine 73 in bleomycin hydrolase is critical for amyloid precursor protein processing

21 January 2018

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The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II.

21 January 2018

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Calcium-dependent polymerization of human serum amyloid P component is inhibited by heparin and dextran sulfate

21 January 2018

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Interaction between Alzheimer's disease beta A4 precursor protein (APP) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans

21 January 2018

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21 January 2018

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Circular-dichroism studies on two murine serum amyloid A proteins

21 January 2018

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An important role of heparan sulfate proteoglycan (Perlecan) in a model system for the deposition and persistence of fibrillar A beta-amyloid in rat brain

21 January 2018

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Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: implications for Alzheimer's disease

21 January 2018

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Conformational changes and disease--serpins, prions and Alzheimer's.

21 January 2018

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Cationic dyes reveal proteoglycans structurally integrated within the characteristic lesions of Alzheimer's disease

21 January 2018

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Alternative conformations of amyloidogenic proteins govern their behavior

21 January 2018

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Common core structure of amyloid fibrils by synchrotron X-ray diffraction.

21 January 2018

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Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy.

21 January 2018

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A molecular model for self-assembly of amyloid fibrils: immunoglobulin light chains.

21 January 2018

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Amyloid precursor protein, copper and Alzheimer's disease

21 January 2018

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Abnormal localization of iron regulatory protein in Alzheimer's disease.

21 January 2018

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Selective accumulation of aluminum and iron in the neurofibrillary tangles of Alzheimer's disease: a laser microprobe (LAMMA) study

21 January 2018

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The galvanization of beta-amyloid in Alzheimer's disease

21 January 2018

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Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits

21 January 2018

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Regional membrane phospholipid alterations in Alzheimer's disease.

21 January 2018

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Active glycation in neurofibrillary pathology of Alzheimer disease: N(epsilon)-(carboxymethyl) lysine and hexitol-lysine

21 January 2018

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Lymphocyte oxidative DNA damage and plasma antioxidants in Alzheimer disease.

21 January 2018

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Hydrogen peroxide mediates amyloid beta protein toxicity

21 January 2018

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Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid

21 January 2018

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A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

21 January 2018

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Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases

21 January 2018

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Role of activating protein-1 in the regulation of the vascular cell adhesion molecule-1 gene expression by tumor necrosis factor-alpha

21 January 2018

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Trans-repressor activity of nuclear glycosaminoglycans on Fos and Jun/AP-1 oncoprotein-mediated transcription

21 January 2018

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Endogenous heparin activity deficiency: the 'missing link' in atherogenesis?

21 January 2018

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Endogenous heparinase-sensitive anticoagulant activity in human plasma

21 January 2018

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Heterozygous lipoprotein lipase deficiency: frequency in the general population, effect on plasma lipid levels, and risk of ischemic heart disease.

21 January 2018

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Lipoprotein lipase increases lipoprotein binding to the artery wall and increases endothelial layer permeability by formation of lipolysis products

21 January 2018

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Chemokines: leucocyte recruitment and activation cytokines.

21 January 2018

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On the edge: the physiological and pathophysiological role of chemokines during inflammatory and immunological responses

21 January 2018

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Chemokine receptors: gateways to inflammation and infection

21 January 2018

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Human chemokines: an update

21 January 2018

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Chemokines and their receptors in the central nervous system

21 January 2018

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Detection of complement alternative pathway mRNA and proteins in the Alzheimer's disease brain.

21 January 2018

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Cytokines associated with amyloid plaques in Alzheimer's disease brain stimulate human glial and neuronal cell cultures to secrete early complement proteins, but not C1-inhibitor.

21 January 2018

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Neuronal expression of a functional receptor for the C5a complement activation fragment

21 January 2018

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The role of complement and activated microglia in the pathogenesis of Alzheimer's disease

21 January 2018

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Acetylcholinesterase clustering at the neuromuscular junction involves perlecan and dystroglycan

21 January 2018

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Neurological cholinesterases in the normal brain and in Alzheimer's disease: relationship to plaques, tangles, and patterns of selective vulnerability.

21 January 2018

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Neuropathological verisimilitude in animal models of Alzheimer's disease: key to elucidating neurodegenerative pathways and identifying new targets for drug discovery

21 January 2018

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Caspase activity sows the seeds of neuronal death

21 January 2018

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Activation of a caspase 3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neurons

21 January 2018

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Involvement of an ICE-like protease in Fas-mediated apoptosis

21 January 2018

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Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-gamma

21 January 2018

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Action of amyloid beta-protein on protein kinase C activity.

21 January 2018

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Evidence for the involvement of protein kinase C in neurodegenerative changes in cultured human cortical neurons

21 January 2018

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Phosphorylation sites of protein kinase C delta in H2O2-treated cells and its activation by tyrosine kinase in vitro

21 January 2018

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Cell surface-bound elastase and cathepsin G on human neutrophils: a novel, non-oxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteinases

21 January 2018

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Heparin selectively inhibits a protein kinase C-dependent mechanism of cell cycle progression in calf aortic smooth muscle cells

21 January 2018

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A new molecular link between the fibrillar and granulovacuolar lesions of Alzheimer's disease

21 January 2018

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Amyloid beta-protein stimulates casein kinase I and casein kinase II activities.

21 January 2018

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Serum amyloid A protein enhances the activity of secretory non-pancreatic phospholipase A2.

21 January 2018

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Synergy by secretory phospholipase A2 and glutamate on inducing cell death and sustained arachidonic acid metabolic changes in primary cortical neuronal cultures.

21 January 2018

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Serine proteases and their serpin inhibitors in Alzheimer's disease

21 January 2018

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Localization of the heparin-binding site of glia-derived nexin/protease nexin-1 by site-directed mutagenesis

21 January 2018

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Protein kinase C potentiation of N-methyl-D-aspartate receptor activity is not mediated by phosphorylation of N-methyl-D-aspartate receptor subunits

21 January 2018

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Dual effects of PKNalpha and protein kinase C on phosphorylation of tau protein by glycogen synthase kinase-3beta.

21 January 2018

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Neuronal cell death and tPA.

21 January 2018

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Proteolytic activities that mediate apoptosis

21 January 2018

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Cathepsin G: localization in human cerebral cortex and generation of amyloidogenic fragments from the beta-amyloid precursor protein

21 January 2018

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Actions of heparin that may affect the malignant process

21 January 2018

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Immunohistochemical detection of myeloperoxidase and its oxidation products in Kupffer cells of human liver

21 January 2018

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MPO and APOEepsilon4 polymorphisms interact to increase risk for AD in Finnish males.

21 January 2018

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Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity

21 January 2018

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Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia

21 January 2018

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Potentiation of excitotoxicity in transgenic mice overexpressing neuronal cyclooxygenase-2

21 January 2018

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Protein oxidation in the brain in Alzheimer's disease

21 January 2018

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Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through N-methyl-D-aspartic acid-receptors and phospholipase A2

21 January 2018

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Glutamate receptor signaling interplay modulates stress-sensitive mitogen-activated protein kinases and neuronal cell death.

21 January 2018

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Superinduction of cyclooxygenase-2 by NO(*) and agonist challenge involves transcriptional regulation mediated by AP-1 activation

21 January 2018

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Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

21 January 2018

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Changes in caspase expression in Alzheimer's disease: comparison with development and aging.

21 January 2018

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A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor

21 January 2018

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Caspases: intracellular signaling by proteolysis

21 January 2018

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Cathepsin B-mediated activation of the proinflammatory caspase-11.

21 January 2018

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Inhibition of human caspases by peptide-based and macromolecular inhibitors

21 January 2018

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Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. Association with endothelial cell proliferation.

21 January 2018

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Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases.

21 January 2018

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A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

21 January 2018

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Regulation of endosome sorting by a specific PP2A isoform

21 January 2018

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

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BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

21 January 2018

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Maturation and pro-peptide cleavage of beta-secretase

21 January 2018

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Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

21 January 2018

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Beta-secretase processing of the beta-amyloid precursor protein in transgenic mice is efficient in neurons but inefficient in astrocytes

21 January 2018

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

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Evolution in the structure and function of aspartic proteases

21 January 2018

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Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration.

21 January 2018

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Inhibition of tau phosphorylating protein kinase cdk5 prevents beta-amyloid-induced neuronal death.

21 January 2018

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Expression of cyclin-dependent kinase 5 and its activator p35 in models of induced apoptotic death in neurons of the substantia nigra in vivo

21 January 2018

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A model of the complex between cyclin-dependent kinase 5 and the activation domain of neuronal Cdk5 activator

21 January 2018

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Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

21 January 2018

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A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation

21 January 2018

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TIMP-2 reduces proteolytic opening of blood-brain barrier by type IV collagenase

21 January 2018

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Inhibition of leucocyte elastase by heparin and its derivatives

21 January 2018

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Cytokine regulation of metalloproteinase gene expression

21 January 2018

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Matrix metalloproteinases and diseases of the CNS.

21 January 2018

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Metalloproteinases and their inhibitors in matrix remodeling

21 January 2018

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Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans.

21 January 2018

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Abnormalities of neural circuitry in Alzheimer's disease: hippocampus and cortical cholinergic innervation

21 January 2018

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Glycosylation of microtubule-associated protein tau: an abnormal posttranslational modification in Alzheimer's disease.

21 January 2018

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Non-enzymic glycation of fibrous collagen: reaction products of glucose and ribose

21 January 2018

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RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

21 January 2018

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Lactoferrin regulates the activity of heparin proteoglycan-bound mast cell chymase: characterization of the binding of heparin to lactoferrin

21 January 2018

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Neurotoxicity of polyamines and pharmacological neuroprotection in cultures of rat cerebellar granule cells.

21 January 2018

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Thrombin stimulates vascular smooth muscle cell polyamine synthesis by inducing cationic amino acid transporter and ornithine decarboxylase gene expression.

21 January 2018

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The role of proteoglycans in cell adhesion, migration and proliferation

21 January 2018

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Neuronal calcium signaling

21 January 2018

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Calcium dysregulation in neuronal aging and Alzheimer's disease: history and new directions

21 January 2018

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Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium

21 January 2018

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Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study.

21 January 2018

1 reference

Inhibition of cortical acetylcholine release and cognitive performance by histamine H3 receptor activation in rats

21 January 2018

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Histamine H3 receptor-mediated impairment of contextual fear conditioning and in-vivo inhibition of cholinergic transmission in the rat basolateral amygdala

21 January 2018

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Delayed onset of Alzheimer's disease with nonsteroidal anti-inflammatory and histamine H2 blocking drugs.

21 January 2018

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The anti-inflammatory action of heparin: Heparin as an antagonist to histamine, bradykinin and prostaglandin E1

21 January 2018

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Receptor-mediated transport of human amyloid beta-protein 1-40 and 1-42 at the blood-brain barrier.

21 January 2018

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The influence of cytokines on the integrity of the blood-brain barrier in vitro.

21 January 2018

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Opening of the blood-brain barrier during cortical superfusion with histamine.

21 January 2018

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Ultrastructural features of the blood-brain barrier in biopsy tissue from Alzheimer's disease patients.

21 January 2018

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A population study on blood-brain barrier function in 85-year-olds: relation to Alzheimer's disease and vascular dementia.

21 January 2018

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beta-Amyloid-mediated vasoactivity and vascular endothelial damage.

21 January 2018

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Quantitative neuronal c-fos and c-jun expression in Alzheimer's disease.

21 January 2018

1 reference

EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology

21 January 2018

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Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain.

21 January 2018

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COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex

21 January 2018

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Neurodegeneration. A silent channel opens its gates.

21 January 2018

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Channel-opening mechanism of a kainate-activated glutamate receptor: kinetic investigations using a laser-pulse photolysis technique.

21 January 2018

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Tissue-transglutaminase in rat and human brain: light and electron immunocytochemical analysis and in situ hybridization study

21 January 2018

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Inhibition of synaptically evoked cortical acetylcholine release by intracortical glutamate: involvement of GABAergic neurons

21 January 2018

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Potentiation of nuclear activator protein-1 DNA binding following brief exposure to N-methyl-D-aspartate in immature cultured rat hippocampal neurons

21 January 2018

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Stimulated increase in free cytosolic Ca(2+) and protein kinase C activity in human cerebrocortical synaptosomes

21 January 2018

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Measured increase in intracellular Ca(2+) during stimulated release of endogenous glutamate from human cerebrocortical synaptosomes

21 January 2018

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Recombinant plasma-type platelet-activating factor acetylhydrolase attenuates NMDA-induced hippocampal neuronal apoptosis.

21 January 2018

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Cyclooxygenases in the central nervous system: implications for treatment of neurological disorders

21 January 2018

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Maturational regulation and regional induction of cyclooxygenase-2 in rat brain: implications for Alzheimer's disease.

21 January 2018

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Modulation of the NMDA receptor by polyamines

21 January 2018

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Polyamines potentiate NMDA induced whole-cell currents in cultured striatal neurons

21 January 2018

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Transglutaminase bonds in neurofibrillary tangles and paired helical filament tau early in Alzheimer's disease

21 January 2018

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The role of apoptosis in neurodegenerative diseases

21 January 2018

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Transglutaminase activity is involved in polyamine-induced programmed cell death.

21 January 2018

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Tissue transglutaminase: a possible role in neurodegenerative diseases

21 January 2018

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Differential expression of multiple transglutaminases in human brain. Increased expression and cross-linking by transglutaminases 1 and 2 in Alzheimer's disease

21 January 2018

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The effects of insulin-like growth factor (IGF)-1, IGF-2, and des-IGF-1 on neuronal loss after hypoxic-ischemic brain injury in adult rats: evidence for a role for IGF binding proteins.

21 January 2018

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Pharmacology of neurotrophic factors

21 January 2018

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Preferential association of the insulin-like growth factors I and II with metabolically inactive and active carrier-bound complexes in serum

21 January 2018

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Glycosaminoglycans inhibit formation of the 140 kDa insulin-like growth factor-binding protein complex

21 January 2018

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The insulin-like growth factor system: basic and clinical aspects

21 January 2018

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Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid- and human amylin-induced toxicity.

21 January 2018

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A role for IGF-1 in the rescue of CNS neurons following hypoxic-ischemic injury

21 January 2018

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Activation of the insulin-like growth factor-I receptor inhibits tumor necrosis factor-induced cell death

21 January 2018

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Insulin-like growth factor I reverses experimental diabetic autonomic neuropathy

21 January 2018

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Basic FGF, NGF, and IGFs protect hippocampal and cortical neurons against iron-induced degeneration.

21 January 2018

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Cell death and control of cell survival in the oligodendrocyte lineage

21 January 2018

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Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study

21 January 2018

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Oxidative stress induces increase in intracellular amyloid beta-protein production and selective activation of betaI and betaII PKCs in NT2 cells

21 January 2018

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Modulation of the age at onset of Parkinson's disease by apolipoprotein E genotypes

21 January 2018

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21 January 2018

Identifiers

DOI

10.1159/000080034

1 reference

10 August 2017

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PubMed ID

15286460