A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors (Q35852826)

10 August 2017

A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors (English)

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10 August 2017

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Debra Akin

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10 August 2017

S Keisin Wang

2

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10 August 2017

Pouran Habibzadegah-Tari

3

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10 August 2017

Brian Law

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10 August 2017

David Ostrov

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10 August 2017

Min Li

6

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10 August 2017

Xiao-Ming Yin

7

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10 August 2017

Jae-Sung Kim

8

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10 August 2017

Nicole Horenstein

9

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10 August 2017

William A Dunn

10

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10 August 2017

language of work or name

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30 October 2014

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10 August 2017

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10

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10 August 2017

2021-2035

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describes a project that uses

10 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4502682/fullTextXML

inferred from PubMed Central ID database lookup

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The mechanism and physiological function of macroautophagy.

11 July 2018

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An overview of autophagy: morphology, mechanism, and regulation

11 July 2018

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Inhibition of c-Met activation sensitizes osteosarcoma cells to cisplatin via suppression of the PI3K-Akt signaling

11 July 2018

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Phase II trial of trastuzumab in combination with cytotoxic chemotherapy for treatment of metastatic osteosarcoma with human epidermal growth factor receptor 2 overexpression: a report from the children's oncology group

11 July 2018

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Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy

11 July 2018

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HMGB1 promotes drug resistance in osteosarcoma

11 July 2018

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Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks

11 July 2018

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11 July 2018

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Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13

11 July 2018

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Role of autophagy in cancer prevention

11 July 2018

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Phosphorylated c-Jun and Fra-1 induce matrix metalloproteinase-1 and thereby regulate invasion activity of 143B osteosarcoma cells

11 July 2018

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Autophagy-deficient mice develop multiple liver tumors

11 July 2018

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High-throughput fluorescence assay for small-molecule inhibitors of autophagins/Atg4.

11 July 2018

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Kinetics comparisons of mammalian Atg4 homologues indicate selective preferences toward diverse Atg8 substrates

11 July 2018

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A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions

11 July 2018

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Autophagy is essential for mouse sense of balance

11 July 2018

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LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis

11 July 2018

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c-Jun NH2-terminal kinase activation is essential for DRAM-dependent induction of autophagy and apoptosis in 2-methoxyestradiol-treated Ewing sarcoma cells

11 July 2018

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Autophagy regulates lipid metabolism

11 July 2018

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Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma

11 July 2018

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Quantitation of autophagy by luciferase release assay.

11 July 2018

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Autophagy is activated in pancreatic cancer cells and correlates with poor patient outcome

11 July 2018

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Autophagy: an emerging target for cancer therapy.

11 July 2018

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Small molecule regulators of autophagy identified by an image-based high-throughput screen

11 July 2018

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Regulation of macroautophagy by mTOR and Beclin 1 complexes

11 July 2018

1 reference

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Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion

11 July 2018

1 reference

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Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis

11 July 2018

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Autophagy suppresses tumor progression by limiting chromosomal instability

11 July 2018

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Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on SRC kinase for survival

11 July 2018

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Comparative biology of human and canine osteosarcoma.

11 July 2018

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Development and validation of a modular, extensible docking program: DOCK 5.

11 July 2018

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Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells

11 July 2018

1 reference

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Signalling and autophagy regulation in health, aging and disease

11 July 2018

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Effects of RNA interference of Atg4B on the limited proteolysis of LC3 in PC12 cells and expression of Atg4B in various rat tissues

11 July 2018

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Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

11 July 2018

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Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagy

11 July 2018

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Synthesis and pharmacological activities of some mononuclear Ru(II) complexes

11 July 2018

1 reference

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WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502682

Regulation and role of autophagy in mammalian cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502682

HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502682

PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502682

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502682

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502682

Starvation-induced lysosomal degradation of aldolase B requires glutamine 111 in a signal sequence for chaperone-mediated transport

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502682

Dissection of autophagosome biogenesis into distinct nucleation and expansion steps

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502682

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502682

Mechanism and regulation of protein degradation in liver

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502682

Mechanism and control of protein and RNA degradation in the rat hepatocyte: two modes of autophagic sequestration

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502682

Studies on the mechanisms of autophagy: formation of the autophagic vacuole

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502682

Cytoskeletal elements are required for the formation and maturation of autophagic vacuoles

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502682

Ubiquitin-activating enzyme, E1, is associated with maturation of autophagic vacuoles

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502682

High expression of LC3B is associated with progression and poor outcome in triple-negative breast cancer

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502682

Autophagy can contribute to cell death when combining targeted therapy

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502682

Hypoxia-induced autophagy contributes to the chemoresistance of hepatocellular carcinoma cells

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502682

Enhancer of zeste homolog 2 downregulates E-cadherin by mediating histone H3 methylation in gastric cancer cells

24 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.4161%2FAUTO.32229

Tissue-specific Autophagy Alterations and Increased Tumorigenesis in Mice Deficient in Atg4C/Autophagin-3

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.4161%2FAUTO.32229

N-phenyl-2-pyridinecarbothioamides as gastric mucosal protectants

21 January 2018

1 reference

12 December 2020

Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes

1 reference

12 December 2020

The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes

1 reference

12 December 2020

LC3, an autophagosome marker, is highly expressed in gastrointestinal cancers

1 reference

12 December 2020

Identifiers

DOI

10.4161/AUTO.32229

1 reference

10 August 2017

1 reference

10 August 2017

PubMed publication ID

25483883

1 reference