MRE11/RAD50/NBS1: complex activities (Q35862243)

10 August 2017

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title

MRE11/RAD50/NBS1: complex activities (English)

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10 August 2017

2

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10 August 2017

Nora Assenmacher

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10 August 2017

10 August 2004

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10 August 2017

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10 August 2017

113

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10 August 2017

4

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10 August 2017

157-166

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https://scigraph.springernature.com/pub.10.1007/s00412-004-0306-4

10 August 2017

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cites work

ATP hydrolysis is required for cohesin's association with chromosomes

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12 December 2020

Chromosomal cohesin forms a ring

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12 December 2020

Overexpression, purification, and characterization of the SbcCD protein from Escherichia coli.

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12 December 2020

Mutations in the MRE11, RAD50, XRS2, and MRE2 genes alter chromatin configuration at meiotic DNA double-stranded break sites in premeiotic and meiotic cells

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12 December 2020

Recombination: a frank view of exchanges and vice versa.

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12 December 2020

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

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12 December 2020

Conserved domains in DNA repair proteins and evolution of repair systems

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12 December 2020

Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest

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12 December 2020

NurA, a novel 5'-3' nuclease gene linked to rad50 and mre11 homologs of thermophilic Archaea

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12 December 2020

Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation

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12 December 2020

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

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12 December 2020

Superfamily of UvrA-related NTP-binding proteins. Implications for rational classification of recombination/repair systems

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12 December 2020

Role of the nuclease activity of Saccharomyces cerevisiae Mre11 in repair of DNA double-strand breaks in mitotic cells.

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12 December 2020

Interaction of FANCD2 and NBS1 in the DNA damage response

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12 December 2020

NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors

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12 December 2020

Werner syndrome protein, the MRE11 complex and ATR: menage-à-trois in guarding genome stability during DNA replication?

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12 December 2020

Effects of mutations of RAD50, RAD51, RAD52, and related genes on illegitimate recombination in Saccharomyces cerevisiae

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12 December 2020

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

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12 December 2020

NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain

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12 December 2020

The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

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12 December 2020

ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses

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12 December 2020

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

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12 December 2020

Enhanced phosphorylation of p53 by ATM in response to DNA damage

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12 December 2020

The coiled-coil of the human Rad50 DNA repair protein contains specific segments of increased flexibility

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12 December 2020

The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

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12 December 2020

Structural and functional analysis of Mre11-3.

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12 December 2020

Regulation of Mre11/Rad50 by Nbs1: effects on nucleotide-dependent DNA binding and association with ataxia-telangiectasia-like disorder mutant complexes.

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12 December 2020

MDC1 is required for the intra-S-phase DNA damage checkpoint

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12 December 2020

Two early genes of bacteriophage T5 encode proteins containing an NTP-binding sequence motif and probably involved in DNA replication, recombination and repair

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12 December 2020

Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination

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12 December 2020

Mating-type gene switching in Saccharomyces cerevisiae

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12 December 2020

Positional cloning of the gene for Nijmegen breakage syndrome

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12 December 2020

DNA replication-dependent nuclear dynamics of the Mre11 complex.

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12 December 2020

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

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12 December 2020

Membrane-associated DNase activity controlled by genes 46 and 47 of bacteriophage T4D and elevated DNase activity associated with the T4 das mutation.

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12 December 2020

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

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12 December 2020

The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance

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12 December 2020

Mechanism and regulation of human non-homologous DNA end-joining

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12 December 2020

The sbcC and sbcD genes of Escherichia coli encode a nuclease involved in palindrome inviability and genetic recombination.

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12 December 2020

Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process

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12 December 2020

Nijmegen breakage syndrome gene, NBS1, and molecular links to factors for genome stability

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12 December 2020

Mre11 assembles linear DNA fragments into DNA damage signaling complexes

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12 December 2020

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

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12 December 2020

Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage

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12 December 2020

BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

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12 December 2020

A mechanistic basis for Mre11-directed DNA joining at microhomologies

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12 December 2020

Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

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12 December 2020

Cancer predisposition and hematopoietic failure in Rad50(S/S) mice

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12 December 2020

Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiae

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12 December 2020

Yeast Xrs2 Binds DNA and Helps Target Rad50 and Mre11 to DNA Ends

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12 December 2020

The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

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12 December 2020

A 160-bp palindrome is a Rad50.Rad32-dependent mitotic recombination hotspot in Schizosaccharomyces pombe

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12 December 2020

Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation

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12 December 2020

Recombination-dependent DNA replication in phage T4.

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12 December 2020

The FHA domain is a modular phosphopeptide recognition motif.

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12 December 2020

The SbcCD nuclease of Escherichia coli is a structural maintenance of chromosomes (SMC) family protein that cleaves hairpin DNA

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12 December 2020

The Saccharomyces cerevisiae mre11(ts) allele confers a separation of DNA repair and telomere maintenance functions

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12 December 2020

The complex matter of DNA double-strand break detection

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12 December 2020

Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes

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12 December 2020

The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

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12 December 2020

Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways

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12 December 2020

Requirement of the MRN complex for ATM activation by DNA damage

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12 December 2020

DNA double-strand breaks and the RAD50-RAD57 genes in Saccharomyces.

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12 December 2020

Disruption of Drosophila Rad50 causes pupal lethality, the accumulation of DNA double-strand breaks and the induction of apoptosis in third instar larvae

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12 December 2020

Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing

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12 December 2020

Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination

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12 December 2020

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12 December 2020

Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest

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12 December 2020

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12 December 2020

DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex

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12 December 2020

Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

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12 December 2020

The Mre11-Rad50-Xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae

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12 December 2020

DNA end-binding specificity of human Rad50/Mre11 is influenced by ATP.

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12 December 2020

Association of Mre11p with double-strand break sites during yeast meiosis.

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12 December 2020

Molecular architecture of SMC proteins and the yeast cohesin complex

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12 December 2020

Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53

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12 December 2020

ATM-dependent phosphorylation of nibrin in response to radiation exposure

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12 December 2020

Human Rad50/Mre11 is a flexible complex that can tether DNA ends

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12 December 2020

Equal Sister Chromatid Exchange Is a Major Mechanism of Double-Strand Break Repair in Yeast

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12 December 2020

Structure of the Rad50 x Mre11 DNA repair complex from Saccharomyces cerevisiae by electron microscopy

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12 December 2020

Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae

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12 December 2020

The Mre11 complex and ATM: collaborating to navigate S phase

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12 December 2020

Tying up loose ends: nonhomologous end-joining in Saccharomyces cerevisiae

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12 December 2020

The tight linkage between DNA replication and double-strand break repair in bacteriophage T4.

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12 December 2020

DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability

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12 December 2020

Asymmetry of DNA replication fork progression in Werner's syndrome

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12 December 2020

DNA damage-dependent nuclear dynamics of the Mre11 complex

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12 December 2020

Recombinational DNA repair and human disease

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12 December 2020

The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements

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12 December 2020

Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells

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12 December 2020

The Mre11 complex is required for ATM activation and the G2/M checkpoint

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12 December 2020

Fission yeast Rad50 stimulates sister chromatid recombination and links cohesion with repair

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12 December 2020

A DNA damage response pathway controlled by Tel1 and the Mre11 complex

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12 December 2020

Mechanism and control of meiotic recombination initiation

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12 December 2020

A bipolar DNA helicase gene, herA, clusters with rad50, mre11 and nurA genes in thermophilic archaea

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12 December 2020

V(D)J recombination: RAG proteins, repair factors, and regulation

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12 December 2020

A model for ATP hydrolysis-dependent binding of cohesin to DNA.

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12 December 2020

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

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12 December 2020

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures

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12 December 2020

Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication.

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12 December 2020

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

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12 December 2020

Chk2 activation dependence on Nbs1 after DNA damage

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12 December 2020

Mre11 and Rad50 from Pyrococcus furiosus: cloning and biochemical characterization reveal an evolutionarily conserved multiprotein machine

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12 December 2020

Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice.

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12 December 2020

Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95

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12 December 2020

Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways

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12 December 2020

Nucleolytic processing of a protein-bound DNA end by the E. coli SbcCD (MR) complex.

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12 December 2020

Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae

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12 December 2020

DNA cleavage and degradation by the SbcCD protein complex from Escherichia coli

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12 December 2020

Telomere maintenance without telomerase

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12 December 2020

Mammalian X ray sensitive mutants: a tool for the elucidation of the cellular response to ionizing radiation

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12 December 2020

MlaA, a hexameric ATPase linked to the Mre11 complex in archaeal genomes

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12 December 2020

The BRCT Domain Is a Phospho-Protein Binding Domain

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12 December 2020

MDC1 is a mediator of the mammalian DNA damage checkpoint

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12 December 2020

Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily

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12 December 2020

Mediator proteins orchestrate enzyme-ssDNA assembly during T4 recombination-dependent DNA replication and repair

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12 December 2020

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint

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12 December 2020

Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells

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12 December 2020

Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis

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12 December 2020

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

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12 December 2020

Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation

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12 December 2020

Nuclear retention of ATM at sites of DNA double strand breaks

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12 December 2020

DNA replication meets genetic exchange: chromosomal damage and its repair by homologous recombination

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12 December 2020

Linkage between Werner syndrome protein and the Mre11 complex via Nbs1.

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12 December 2020

The yeast Xrs2 complex functions in S phase checkpoint regulation

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12 December 2020

Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase

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12 December 2020

Distinct pathways of nonhomologous end joining that are differentially regulated by DNA-dependent protein kinase-mediated phosphorylation

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12 December 2020

10.1007/S00412-004-0306-4

Identifiers

DOI

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10 August 2017

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PubMed ID

15309560