A review of selected anti-tumour therapeutic agents and reasons for multidrug resistance occurrence (Q35868560)

10 August 2017

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title

A review of selected anti-tumour therapeutic agents and reasons for multidrug resistance occurrence (English)

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10 August 2017

multiple drug resistance

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Sawicka M

1

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10 August 2017

Kalinowska M

series ordinal

2

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10 August 2017

Skierski J

series ordinal

3

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10 August 2017

Lewandowski W

series ordinal

4

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10 August 2017

1 September 2004

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Journal of Pharmacy and Pharmacology

10 August 2017

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10 August 2017

56

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10 August 2017

9

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10 August 2017

1067-1081

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Biochemical, cellular, and pharmacological aspects of the multidrug transporter

10 August 2017

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Eukaryotic DNA topoisomerase II beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Cross-talk between Bcr-Abl tyrosine kinase, protein kinase C and telomerase-a potential reason for resistance to Glivec in chronic myelogenous leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Membrane topology and glycosylation of the human multidrug resistance-associated protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Identification of a multidrug resistance-like system in Tetrahymena pyriformis: evidence for a new detoxication mechanism in freshwater ciliates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

SB203580, a specific inhibitor of p38-MAPK pathway, is a new reversal agent of P-glycoprotein-mediated multidrug resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

A family of drug transporters: the multidrug resistance-associated proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Toxicologic and pharmacokinetic study of low doses of verapamil combined with doxorubicin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Cardioprotective effects of verapamil on myocardial structure and function in a murine model of chronic Trypanosoma cruzi infection (Brazil Strain): an echocardiographic study

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Dynamics of human DNA topoisomerases IIalpha and IIbeta in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Characterization and modulation of drug resistance of human paediatric rhabdomyosarcoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Gleevec for the treatment of chronic myelogenous leukemia: US. Food and Drug Administration regulatory mechanisms, accelerated approval, and orphan drug status

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

EVE/cyclosporin (etoposide, vincristine, epirubicin with high-dose cyclosporin)-chemotherapy selected for multidrug resistance modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Dual topoisomerase I/II inhibitors in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

P-glycoprotein inserted in planar lipid bilayers formed by liposomes opened on amorphous carbon and Langmuir-Blodgett monolayer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Effect of modification of 6-[(aminoalkyl)amino]-7H-benzo[e]-perimidin-7-ones on their cytotoxic activity toward sensitive and multidrug resistant tumor cell lines. Synthesis and biological evaluation

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Combined genetic polymorphism and risk for development of lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Effects of P-glycoprotein inhibitors on cadmium accumulation in cultured renal epithelial cells, LLC-PK1, and OK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Classification of anticancer drugs—a new system based on therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Multidrug resistance-associated proteins in glaucoma surgery

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Inhibition of P-glycoprotein: rapid assessment of its implication in blood-brain barrier integrity and drug transport to the brain by an in vitro model of the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

The role of topotecan in the treatment of advanced cervical cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Recognition of DNA modified by antitumor cisplatin by “latent” and “active” protein p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Experimental reversal of P-glycoprotein-mediated multidrug resistance by pharmacological chemosensitisers

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

The multidrug resistance of tumour cells was reversed by tetrandrine in vitro and in xenografts derived from human breast adenocarcinoma MCF-7/adr cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Structure and biological activity of cationic [PtLCl(DMSO)]NO(3).DMSO complex containing a chelated diaminosugar: methyl-3,4-diamino-2,3,4,6-tetradeoxy-alpha-L-lyxopyranoside

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Verapamil suppresses the emergence of P-glycoprotein-mediated multi-drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

MDR1 inhibition: less resistance or less relevance?

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Critical appraisals of approaches for predictive designs in anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Mechanisms of cancer drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Genetic analysis of the multidrug transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Alterations in the expression of cytochrome c oxidase subunits in doxorubicin-resistant leukemia K562 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Dynamics of multidrug resistance: P-glycoprotein analyses with positron emission tomography

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Comparison of the protective effects of amifostine and dexrazoxane against the toxicity of doxorubicin in spontaneously hypertensive rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Clinical experience with topotecan in relapsed ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

ABC transporters: physiology, structure and mechanism--an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

ras mutation and platinum resistance in human ovarian carcinomas in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Treatment options for endometrial cancer: experience with topotecan

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

DNA and its associated processes as targets for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Doxorubicin-induced congestive heart failure in elderly patients with metastatic breast cancer, with long-term follow-up: the M.D. Anderson experience

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

A formula for predicting optimal dosage of nedaplatin based on renal function in adult cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Structure, Recognition, and Processing of Cisplatin-DNA Adducts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

A dual mechanism of action of the anticancer agent F 11782 on human topoisomerase II alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

A new structural model for P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Mechanisms of resistance to cisplatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Transmembrane organization of mouse P-glycoprotein determined by epitope insertion and immunofluorescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

DA-125, a novel anthracycline derivative showing high-affinity DNA binding and topoisomerase II inhibitory activities, exerts cytotoxicity via c-Jun N-terminal kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Reversal of P-glycoprotein-mediated multidrug resistance by ginsenoside Rg(3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

P-glycoprotein inhibition by the multidrug resistance-reversing agent MS-209 enhances bioavailability and antitumor efficacy of orally administered paclitaxel

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Induction of apoptosis in mouse brain capillary endothelial cells by cyclosporin A and tacrolimus

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Functional and physical interactions between ERCC1 and MSH2 complexes for resistance to cis-diamminedichloroplatinum(II) in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Structural organization of the human TOP2A and TOP2B genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

ATP binding cassette transporters and drug resistance in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Modulation of excision repair cross complementation group 1 (ERCC-1) mRNA expression by pharmacological agents in human ovarian carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

The copper transporter CTR1 regulates cisplatin uptake in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Characterization of the human topoisomerase IIbeta (TOP2B) promoter activity: essential roles of the nuclear factor-Y (NF-Y)- and specificity protein-1 (Sp1)-binding sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Concurrent chemoradiotherapy with new platinum compound nedaplatin in oral cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Cell cycle-coupled relocation of types I and II topoisomerases and modulation of catalytic enzyme activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Mechanism of action of the dual topoisomerase-I and -II inhibitor TAS-103 and activity against (multi)drug resistant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Identification of functional nuclear export sequences in human topoisomerase IIalpha and beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Weekly topotecan in the management of ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Verapamil decreases P-glycoprotein expression in multidrug-resistant human leukemic cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Molecular analysis of mechanisms regulating drug sensitivity and the development of new chemotherapy strategies for genitourinary carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Epirubicin or epirubicin and cisplatin as first-line therapy in advanced breast cancer. A phase III study

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Influence of chemosensitizers on resistance mechanisms in daunorubicin-resistant Ehrlich ascites tumour cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Molecular mechanisms of multidrug resistance in cancer chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Tricyclic isoxazoles are novel inhibitors of the multidrug resistance protein (MRP1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Glutathione and related enzymes in multidrug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Analysis of glutathione: implication in redox and detoxification

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Detection of a P-glycoprotein related pump in Chironomus larvae and its inhibition by verapamil and cyclosporin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

The role of the MDR protein in altered drug translocation across tumor cell membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Platinum Compounds: a New Class of Potent Antitumour Agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

STI-571: an anticancer protein-tyrosine kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Combined effect of polymorphic GST genes on individual susceptibility to lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Cyclosporin A inhibits the extrusion pump function of p-glycoprotein in the inner ear of mice treated with vinblastine and doxorubicin

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Dexrazoxane significantly impairs the induction of doxorubicin resistance in the human leukaemia line, K562

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Insights into the structure and substrate interactions of the P-glycoprotein multidrug transporter from spectroscopic studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Reduced activity of topoisomerase II in an Adriamycin-resistant human stomach-adenocarcinoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Multidrug resistance in acute myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Changing concepts in multiple myeloma: from conventional chemotherapy to high-dose treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Pharmacogenomics of ABC transporters and its role in cancer chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Synthesis and biological evaluation of 2,7-Dihydro-3H-dibenzo[de,h]cinnoline-3,7-dione derivatives, a novel group of anticancer agents active on a multidrug resistant cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Glutathion S transferase pi indicates chemotherapy resistance in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Mechanisms of transport across cell membranes of complexes contained in antitumour drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

The medicinal chemistry of multidrug resistance (MDR) reversing drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Inhibition of DNA topoisomerases I and II, and growth inhibition of human cancer cell lines by a marine microalgal polysaccharide

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Human placental transport of vinblastine, vincristine, digoxin and progesterone: contribution of P-glycoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Antibiotic efflux pumps in eukaryotic cells: occurrence and impact on antibiotic cellular pharmacokinetics, pharmacodynamics and toxicodynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Partial characterization of the DNA repair protein complex, containing the ERCC1, ERCC4, ERCC11 and XPF correcting activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Verapamil: new insight into the molecular mechanism of drug oxidation in the human heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Association between glutathione S-transferase p1 polymorphisms and lung cancer risk in Caucasians: a case-control study

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Mechanisms of resistance imatinib (STI571) in preclinical models and in leukemia patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

A new era in cancer therapeutics?

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Increased intracellular doxorubicin by anti-FAS monoclonal antibody: a mechanism that enhances the cytotoxicity in renal cell carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Total synthesis of dendroamide A, a novel cyclic peptide that reverses multiple drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Cyclin A in cell cycle control and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Topoisomerase II alpha content and topoisomerase II catalytic activity cannot explain drug sensitivities to topoisomerase II inhibitors in lung cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Decreased cisplatin/DNA adduct formation is associated with cisplatin resistance in human head and neck cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Involvement of phosphatidylinositol-3-kinase in membrane ruffling induced by P-glycoprotein substrates in multidrug-resistant carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Prolonged wild-type p53 protein accumulation and cisplatin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Reversal of adriamycin resistance in ovarian carcinoma cell line by combination of verapamil and low-level ultrasound.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Cisplatin and DNA repair in cancer chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

New metal complexes as potential therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Induction of P-glycoprotein expression in astrocytes following intracerebroventricular kainate injections.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Shiga-like toxin II modifies brain distribution of a P-glycoprotein substrate, doxorubicin, and P-glycoprotein expression in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

Frequency of glutathione S-transferase M1 deletion in smokers with emphysema and lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357044265

21 January 2018

Identifiers

DOI

10.1211/0022357044265

1 reference

10 August 2017

1 reference