Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein. (Q40704865)

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13 November 2019

title

Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein (English)

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13 November 2019

main subject

multiple drug resistance

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1

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13 November 2019

author name string

David M Clarke

series ordinal

2

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13 November 2019

language of work or name

English

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publication date

9 September 2002

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Journal of Biological Chemistry

13 November 2019

published in

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13 November 2019

volume

277

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13 November 2019

issue

46

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13 November 2019

page(s)

44332-44338

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Molecular genetic analysis and biochemical characterization of mammalian P-glycoproteins involved in multidrug resistance

13 November 2019

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HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.

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Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs

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Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

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Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

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Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

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Membrane topology of a cysteine-less mutant of human P-glycoprotein

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Transmembrane organization of mouse P-glycoprotein determined by epitope insertion and immunofluorescence

21 January 2018

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The minimum functional unit of human P-glycoprotein appears to be a monomer.

21 January 2018

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The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface.

21 January 2018

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Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance

21 January 2018

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Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity

21 January 2018

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ATP hydrolysis cycles and mechanism in P-glycoprotein and CFTR.

21 January 2018

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Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS-verapamil

21 January 2018

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Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site.

21 January 2018

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Human epidermal growth factor precursor: cDNA sequence, expression in vitro and gene organization

21 January 2018

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Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.

21 January 2018

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DNA sequencing with chain-terminating inhibitors

21 January 2018

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Superfolding of the partially unfolded core-glycosylated intermediate of human P-glycoprotein into the mature enzyme is promoted by substrate-induced transmembrane domain interactions.

21 January 2018

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Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein

21 January 2018

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Altered drug-stimulated ATPase activity in mutants of the human multidrug resistance protein

21 January 2018

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Novel sulfhydryl reagents

21 January 2018

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P-glycoprotein. Associations between domains and between domains and molecular chaperones

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Mutational analysis of human P-glycoprotein.

21 January 2018

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Blockage of drug resistance in vitro by disulfiram, a drug used to treat alcoholism

21 January 2018

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Cross-linking of human multidrug resistance P-glycoprotein by the substrate, tris-(2-maleimidoethyl)amine, is altered by ATP hydrolysis. Evidence for rotation of a transmembrane helix.

21 January 2018

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Determining the dimensions of the drug-binding domain of human P-glycoprotein using thiol cross-linking compounds as molecular rulers

21 January 2018

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Identification of the cyclosporin-binding site in P-glycoprotein

21 January 2018

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Identification of ligand-binding regions of P-glycoprotein by activated-pharmacophore photoaffinity labeling and matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry.

21 January 2018

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A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdr3 drug efflux pumps

21 January 2018

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Mutations to amino acids located in predicted transmembrane segment 6 (TM6) modulate the activity and substrate specificity of human P-glycoprotein

21 January 2018

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The packing of the transmembrane segments of human multidrug resistance P-glycoprotein is revealed by disulfide cross-linking analysis.

21 January 2018

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Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

21 January 2018

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Multidrug resistance transporter P-glycoprotein has distinct but interacting binding sites for cytotoxic drugs and reversing agents

21 January 2018

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Inhibition of Oxidative Cross-linking between Engineered Cysteine Residues at Positions 332 in Predicted Transmembrane Segments (TM) 6 and 975 in Predicted TM12 of Human P-glycoprotein by Drug Substrates

21 January 2018

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Identification of Residues in the Drug-binding Site of Human P-glycoprotein Using a Thiol-reactive Substrate

21 January 2018

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Identification of Residues in the Drug-binding Domain of Human P-glycoprotein

21 January 2018

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Identification of Residues within the Drug-binding Domain of the Human Multidrug Resistance P-glycoprotein by Cysteine-scanning Mutagenesis and Reaction with Dibromobimane

21 January 2018

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Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators

21 January 2018

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Molecular dissection of the human multidrug resistance P-glycoprotein

21 January 2018

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Drug-stimulated ATPase Activity of Human P-glycoprotein Requires Movement between Transmembrane Segments 6 and 12

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M208433200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12223492%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

1 reference