Genomic and functional analysis identifies CRKL as an oncogene amplified in lung cancer (Q35873554)

10 August 2017

Genomic and functional analysis identifies CRKL as an oncogene amplified in lung cancer (English)

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10 August 2017

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12

J R Pollack

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10 August 2017

Y H Kim

1

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10 August 2017

K A Kwei

2

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10 August 2017

L Girard

3

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10 August 2017

K Salari

4

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10 August 2017

J Kao

5

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10 August 2017

M Pacyna-Gengelbach

6

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10 August 2017

P Wang

7

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10 August 2017

T Hernandez-Boussard

8

1 reference

10 August 2017

A F Gazdar

9

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10 August 2017

I Petersen

10

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10 August 2017

J D Minna

11

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10 August 2017

language of work or name

English

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publication date

7 December 2009

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10 August 2017

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29

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10

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10 August 2017

1421-1430

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https://scigraph.springernature.com/pub.10.1038/onc.2009.437

10 August 2017

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cites work

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11 July 2018

Cancer statistics, 2008

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Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer

11 July 2018

1 reference

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Characterizing the cancer genome in lung adenocarcinoma

11 July 2018

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Oncogenic cooperation and coamplification of developmental transcription factor genes in lung cancer

11 July 2018

1 reference

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Spatial smoothing and hot spot detection for CGH data using the fused lasso

11 July 2018

1 reference

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Lung cancer cell lines harboring MET gene amplification are dependent on Met for growth and survival

11 July 2018

1 reference

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Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene-expression subtypes of breast cancer

11 July 2018

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Active (p)CrkL is overexpressed in human malignancies: potential role as a surrogate parameter for therapeutic tyrosine kinase inhibition

11 July 2018

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High resolution analysis of non-small cell lung cancer cell lines by whole genome tiling path array CGH.

11 July 2018

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Array-based comparative genomic hybridization identifies localized DNA amplifications and homozygous deletions in pancreatic cancer

11 July 2018

1 reference

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Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis

11 July 2018

1 reference

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High-resolution genomic profiles of human lung cancer

11 July 2018

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Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins

11 July 2018

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EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

11 July 2018

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

11 July 2018

1 reference

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c-MET mutational analysis in small cell lung cancer: novel juxtamembrane domain mutations regulating cytoskeletal functions

11 July 2018

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The docking protein Gab2 is overexpressed and estrogen regulated in human breast cancer

11 July 2018

1 reference

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The human genome browser at UCSC

11 July 2018

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Crk family adaptors-signalling complex formation and biological roles

11 July 2018

1 reference

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Met receptor tyrosine kinase: enhanced signaling through adapter proteins

11 July 2018

1 reference

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Cell-penetrating SH3 domain blocker peptides inhibit proliferation of primary blast cells from CML patients

11 July 2018

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Selective GRB2 SH2 inhibitors as anti-Ras therapy

11 July 2018

1 reference

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Genome-wide analysis of DNA copy-number changes using cDNA microarrays

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320568

Role of the adapter protein CRKL in signal transduction of normal hematopoietic and BCR/ABL-transformed cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320568

Tyrosine 207 in CRKL is the BCR/ABL phosphorylation site

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320568

The CRKL adaptor protein transforms fibroblasts and functions in transformation by the BCR-ABL oncogene

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320568

Isolation and chromosomal localization of CRKL, a human crk-like gene

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320568

Cellular interactions of CRKL, and SH2-SH3 adaptor protein

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320568

The SH2 domain protein GRB-7 is co-amplified, overexpressed and in a tight complex with HER2 in breast cancer

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320568

Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320568

Crkl enhances leukemogenesis in BCR/ABL P190 transgenic mice.

24 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19966867

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Overexpression of the Grb2 gene in human breast cancer cell lines

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19966867

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/ONC.2009.437

1 reference

10 August 2017

1 reference

10 August 2017

1 reference