Self-representation in the thymus: an extended view (Q35877206)

10 August 2017

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title

Self-representation in the thymus: an extended view (English)

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10 August 2017

Bruno Kyewski

1

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10 August 2017

Jens Derbinski

series ordinal

2

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10 August 2017

publication date

1 September 2004

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Nature Reviews Immunology

10 August 2017

published in

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10 August 2017

volume

4

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10 August 2017

issue

9

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10 August 2017

page(s)

688-698

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Innate immunity: the virtues of a nonclonal system of recognition

10 August 2017

cites work

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Self-antigen presentation by thymic stromal cells: a subtle division of labor

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Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.

21 January 2018

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Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters

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Multiple sclerosis candidate autoantigens except myelin oligodendrocyte glycoprotein are transcribed in human thymus.

21 January 2018

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Different patterns of nicotinic acetylcholine receptor subunit transcription in human thymus.

21 January 2018

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Promiscuous gene expression and central T-cell tolerance: more than meets the eye.

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Back to central tolerance

21 January 2018

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The intrathymic expression of insulin-related genes: implications for pathophysiology and prevention of Type 1 diabetes

21 January 2018

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Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance

21 January 2018

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21 January 2018

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Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR.

21 January 2018

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Stem cells of the skin epithelium

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Medullary thymic epithelium: a mosaic of epithelial "self"?

21 January 2018

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Organization of thymic medullary epithelial heterogeneity: implications for mechanisms of epithelial differentiation.

21 January 2018

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Lymphotoxin pathway directs thymic Aire expression

21 January 2018

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Autoimmune regulator: from loss of function to autoimmunity.

21 January 2018

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Projection of an immunological self shadow within the thymus by the aire protein

21 January 2018

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Aire regulates negative selection of organ-specific T cells

21 January 2018

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The autoimmune regulator (AIRE) is a DNA-binding protein

21 January 2018

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NF-kappa B-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner.

21 January 2018

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Human thymic stromal lymphopoietin promotes dendritic cell-mediated CD4+ T cell homeostatic expansion.

21 January 2018

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The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.

21 January 2018

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Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.

21 January 2018

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Thymus epithelium induces tissue-specific tolerance

21 January 2018

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An immunologically privileged retinal antigen elicits tolerance: major role for central selection mechanisms

21 January 2018

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Thymic emigration: conveyor belts or lucky dips?

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Dynamics of CD8+ T cell priming by dendritic cells in intact lymph nodes

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Chemokines and lymphopoiesis in human thymus.

21 January 2018

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CCR7 directs the migration of thymocytes into the thymic medulla

21 January 2018

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The strategy of T cell antigen-presenting cell encounter in antigen-draining lymph nodes revealed by imaging of initial T cell activation.

21 January 2018

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T cell tolerance to a neo-self antigen expressed by thymic epithelial cells: the soluble form is more effective than the membrane-bound form

21 January 2018

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Quantitative constraints on the scope of negative selection

21 January 2018

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Expression of self-antigen in the thymus: a little goes a long way.

21 January 2018

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Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses

21 January 2018

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Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells

21 January 2018

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Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

21 January 2018

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An essential role for Scurfin in CD4+CD25+ T regulatory cells

21 January 2018

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

21 January 2018

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Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential

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Regulating the immune response to transplants. a role for CD4+ regulatory cells?

21 January 2018

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The genetic background of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy and its autoimmune disease components

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Prevalence and clinical associations of 10 defined autoantibodies in autoimmune polyendocrine syndrome type I.

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Does GAD have a unique role in triggering IDDM?

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Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells.

21 January 2018

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High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire

21 January 2018

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Glycosylation of type II collagen is of major importance for T cell tolerance and pathology in collagen-induced arthritis

21 January 2018

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A listing of human tumor antigens recognized by T cells

21 January 2018

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Anti-sperm antibodies from infertile patients and their cognate sperm antigens: a review. Identity between SAGA-1, the H6-3C4 antigen, and CD52.

21 January 2018

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Apoptosis and CD95 ligand in immune privileged sites

21 January 2018

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Thymic selection revisited: how essential is it?

21 January 2018

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The role of DNA breaks in genomic instability and tumorigenesis

21 January 2018

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21 January 2018

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Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation

21 January 2018

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Cell migration and the control of post-natal T-cell lymphopoiesis in the thymus

21 January 2018

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Two subsets of epithelial cells in the thymic medulla

21 January 2018

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Developing a new paradigm for thymus organogenesis.

21 January 2018

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Antigen presentation by dendritic cells in vivo

21 January 2018

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Clinical review 130: Addison's disease 2001.

21 January 2018

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Characterization of H+,K+-ATPase T cell epitopes in human autoimmune gastritis.

21 January 2018

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The genetics of autoimmune thyroid disease.

21 January 2018

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Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system

21 January 2018

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Unravelling the pathogenesis of myasthenia gravis

21 January 2018

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Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion

21 January 2018

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Predominant selection of T cells specific for the glycosylated collagen type II epitope (263-270) in humanized transgenic mice and in rheumatoid arthritis

21 January 2018

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Specific cytotoxic T lymphocyte responses against Melan-A/MART1, tyrosinase and gp100 in vitiligo by the use of major histocompatibility complex/peptide tetramers: the role of cellular immunity in the etiopathogenesis of vitiligo.

21 January 2018

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Cytotoxic T lymphocyte reactivity to gp100, MelanA/MART-1, and tyrosinase, in HLA-A2-positive vitiligo patients

21 January 2018

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Peripheral T-cell tolerance: the contribution of permissive T-cell migration into parenchymal tissues of the neonate

21 January 2018

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Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues II. Concomitant and mutually exclusive synthesis of trichocytic and epithelial cytokeratins in diverse human and bovine tissues (hair follicle, nail bed and matrix

31 March 2020

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T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus

31 March 2020

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The major myelin protein genes are expressed in the human thymus.

31 March 2020

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How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model

31 March 2020

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An acetylcholine receptor alpha subunit promoter confers intrathymic expression in transgenic mice. Implications for tolerance of a transgenic self-antigen and for autoreactivity in myasthenia gravis

31 March 2020

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Mechanisms of immune tolerance induction through the thymic expression of a peripheral tissue-specific protein

31 March 2020

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Tolerance, danger, and the extended family

31 March 2020

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Gut instincts: thoughts on intestinal epithelial stem cells

31 March 2020

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Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes

31 March 2020

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Tight junction-related structures in the absence of a lumen: occludin, claudins and tight junction plaque proteins in densely packed cell formations of stratified epithelia and squamous cell carcinomas

31 March 2020

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Proinsulin expression by Hassall's corpuscles in the mouse thymus.

31 March 2020

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Anergy induced by thymic medullary epithelium

31 March 2020

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Tolerance induction by thymic medullary epithelium

31 March 2020

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Intrathymic and extrathymic tolerance in bone marrow chimeras

31 March 2020

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Deletion of high-avidity T cells by thymic epithelium

31 March 2020

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Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance

31 March 2020

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Chemokines define distinct microenvironments in the developing thymus

31 March 2020

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Evidence for a thymus-dependent form of tolerance that is not based on elimination or anergy of reactive T cells

31 March 2020

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A model for developmentally acquired thymus-dependent tolerance to central and peripheral antigens

31 March 2020

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Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

31 March 2020

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Origin of regulatory T cells with known specificity for antigen

31 March 2020

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GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes

31 March 2020

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Controlling the controls: GAD65 autoreactive T cells in type 1 diabetes

31 March 2020

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Mice resistant to experimental autoimmune encephalomyelitis have increased thymic expression of myelin basic protein and increased MBP specific T cell tolerance

31 March 2020

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Heterozygous null mutation of myelin P0 protein enhances susceptibility to autoimmune neuritis targeting P0 peptide

31 March 2020

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Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice

31 March 2020

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The epitope spreading cascade during progression of experimental autoimmune encephalomyelitis and multiple sclerosis

31 March 2020

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Differential expression of human nicotinic acetylcholine receptor alpha subunit variants in muscle and non-muscle tissues

31 March 2020

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Differential splicing of the IA-2 mRNA in pancreas and lymphoid organs as a permissive genetic mechanism for autoimmunity against the IA-2 type 1 diabetes autoantigen

31 March 2020

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31 March 2020

Cancer Tumor antigens

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Structure and expression of the mouse casein gene locus

31 March 2020

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Presentation and intercellular transfer of self antigen within the thymic microenvironment: expression of the E alpha peptide-I-Ab complex by isolated thymic stromal cells

31 March 2020

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Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node

31 March 2020

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Insulin-dependent diabetes mellitus

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1436

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10 August 2017

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