Aire regulates negative selection of organ-specific T cells (Q28213185)

4

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Sylvie Lesage

object named as

Sylvie Lesage

2

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Adrian Liston

object named as

Adrian Liston

1

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author name string

Judith Wilson

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Christopher C Goodnow

Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice

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language of work or name

English

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publication date

April 2003

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published in

Nature Immunology

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volume

4

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page(s)

350-4

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issue

4

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cites work

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A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis.

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The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein

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Mutations in the AIRE gene: effects on subcellular location and transactivation function of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy protein

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Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

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Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla.

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Localization of the APECED protein in distinct nuclear structures

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Projection of an immunological self shadow within the thymus by the aire protein

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Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes.

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Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus

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Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

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Some quantitative aspects of T-cell repertoire selection: the requirement for regulatory T cells

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RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouse

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T lymphocyte tolerance: from thymic deletion to peripheral control mechanisms

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High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire

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Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position

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