Antiprion immunotherapy: to suppress or to stimulate? (Q35877214)

10 August 2017

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title

Antiprion immunotherapy: to suppress or to stimulate? (English)

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10 August 2017

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Adriano Aguzzi

1

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Christina J. Sigurdson

series ordinal

2

object named as

Christina J Sigurdson

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10 August 2017

1 September 2004

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Nature Reviews Immunology

10 August 2017

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10 August 2017

4

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10 August 2017

9

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10 August 2017

725-736

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Games played by rogue proteins in prion disorders and Alzheimer's disease

10 August 2017

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A novel progressive spongiform encephalopathy in cattle.

21 January 2018

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Bovine spongiform encephalopathy and early onset variant Creutzfeldt-Jakob disease

21 January 2018

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Inactivation of transmissible degenerative encephalopathy agents: A review

21 January 2018

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A route for prion neuroinvasion.

21 January 2018

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Scrapie prion protein contains a phosphatidylinositol glycolipid

21 January 2018

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Cellular prion protein status in sheep: tissue-specific biochemical signatures

21 January 2018

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Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

21 January 2018

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Prion protein is necessary for normal synaptic function.

21 January 2018

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Prion protein structural features indicate possible relations to signal peptidases.

21 January 2018

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Prion protein-deficient cells show altered response to oxidative stress due to decreased SOD-1 activity.

21 January 2018

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Normal prion protein has an activity like that of superoxide dismutase.

21 January 2018

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Impairment of superoxide dismutase activation by N-terminally truncated prion protein (PrP) in PrP-deficient neuronal cell line

21 January 2018

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Eight prion strains have PrP(Sc) molecules with different conformations

21 January 2018

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Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein

21 January 2018

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A 'unified theory' of prion propagation

21 January 2018

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RNA molecules stimulate prion protein conversion

21 January 2018

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Prion research: the next frontiers.

21 January 2018

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Soluble dimeric prion protein binds PrP(Sc) in vivo and antagonizes prion disease.

21 January 2018

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Mammalian prion biology: one century of evolving concepts

21 January 2018

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A protease-resistant protein is a structural component of the scrapie prion.

21 January 2018

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

21 January 2018

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Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie

21 January 2018

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Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.

21 January 2018

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Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene

21 January 2018

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Mice devoid of PrP are resistant to scrapie

21 January 2018

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Normal host prion protein necessary for scrapie-induced neurotoxicity.

21 January 2018

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Specificity of lymphoreticular accumulation of prion protein for variant Creutzfeldt-Jakob disease.

21 January 2018

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Detection of disease‐specific PrP in the distal ileum of cattle exposed orally to the agent of bovine spongiform encephalopathy

21 January 2018

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Preliminary observations on the pathogenesis of experimental bovine spongiform encephalopathy (BSE): an update.

21 January 2018

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Extraneural pathologic prion protein in sporadic Creutzfeldt-Jakob disease.

21 January 2018

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Pathogenesis of prion diseases: possible implications of microglial cells

21 January 2018

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Evidence for an early inflammatory response in the central nervous system of mice with scrapie.

21 January 2018

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Atypical inflammation in the central nervous system in prion disease

21 January 2018

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A crucial role for B cells in neuroinvasive scrapie.

21 January 2018

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Complement facilitates early prion pathogenesis.

21 January 2018

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Prion pathogenesis in the absence of Toll-like receptor signalling

21 January 2018

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Prions and the immune system: a journey through gut, spleen, and nerves

21 January 2018

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Oral prion infection requires normal numbers of Peyer's patches but not of enteric lymphocytes

21 January 2018

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Migrating intestinal dendritic cells transport PrP(Sc) from the gut.

21 January 2018

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Infected splenic dendritic cells are sufficient for prion transmission to the CNS in mouse scrapie

21 January 2018

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Lymph nodal prion replication and neuroinvasion in mice devoid of follicular dendritic cells

21 January 2018

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Impaired prion replication in spleens of mice lacking functional follicular dendritic cells

21 January 2018

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Follicular dendritic cell dedifferentiation by treatment with an inhibitor of the lymphotoxin pathway dramatically reduces scrapie susceptibility

21 January 2018

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PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain.

21 January 2018

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Efficient lymphoreticular prion propagation requires PrP(c) in stromal and hematopoietic cells.

21 January 2018

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A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen

21 January 2018

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Cerebral targeting indicates vagal spread of infection in hamsters fed with scrapie

21 January 2018

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Sympathetic innervation of lymphoreticular organs is rate limiting for prion neuroinvasion

21 January 2018

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Effectiveness of anthracycline against experimental prion disease in Syrian hamsters.

21 January 2018

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Porphyrin and phthalocyanine antiscrapie compounds.

21 January 2018

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Branched polyamines cure prion-infected neuroblastoma cells

21 January 2018

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PrP(CWD) lymphoid cell targets in early and advanced chronic wasting disease of mule deer

21 January 2018

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The requirement of membrane lymphotoxin for the presence of dendritic cells in lymphoid tissues

21 January 2018

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Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function

21 January 2018

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A Toll-like receptor recognizes bacterial DNA

21 January 2018

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Postexposure prophylaxis against prion disease with a stimulator of innate immunity

21 January 2018

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Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration

21 January 2018

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Prion protein is a component of the multimolecular signaling complex involved in T cell activation.

21 January 2018

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Cellular isoform of the scrapie agent protein participates in lymphocyte activation

21 January 2018

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Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies.

21 January 2018

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Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody

21 January 2018

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Antibodies inhibit prion propagation and clear cell cultures of prion infectivity

21 January 2018

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Dominant-negative inhibition of prion replication in transgenic mice

21 January 2018

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Normal host prion protein (PrPC) is required for scrapie spread within the central nervous system

21 January 2018

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Induction of antibodies against murine full-length prion protein in wild-type mice

21 January 2018

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vCJD tissue distribution and transmission by transfusion--a worst-case scenario coming true?

21 January 2018

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Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusion.

21 January 2018

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Interventional strategies against prion diseases

21 January 2018

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A new variant of Creutzfeldt-Jakob disease in the UK.

21 January 2018

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Transmission of BSE by blood transfusion in sheep

21 January 2018

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Human prion diseases: epidemiology and integrated risk assessment

21 January 2018

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Prions: health scare and biological challenge.

21 January 2018

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Course of experimental scrapie virus infection in the goat

21 January 2018

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Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cells

21 January 2018

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Oral transmission of kuru, Creutzfeldt-Jakob disease, and scrapie to nonhuman primates

21 January 2018

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Humanized knock-in mice expressing chimeric prion protein showed varied susceptibility to different human prions

21 January 2018

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BSE prions propagate as either variant CJD-like or sporadic CJD-like prion strains in transgenic mice expressing human prion protein

21 January 2018

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Comparison of the neuropathological characteristics of bovine spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (vCJD) in mice.

21 January 2018

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First experimental transmission of fatal familial insomnia.

21 January 2018

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Transmission of scrapie in hamsters.

21 January 2018

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Markedly increased susceptibility to natural sheep scrapie of transgenic mice expressing ovine prp.

21 January 2018

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The host range of chronic wasting disease is altered on passage in ferrets.

21 January 2018

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Natural and experimental oral infection of nonhuman primates by bovine spongiform encephalopathy agents

21 January 2018

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Transmission of feline spongiform encephalopathy to mice.

21 January 2018

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Transmission of prion diseases by blood transfusion

21 January 2018

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Neuro-immune connection in spread of prions in the body?

21 January 2018

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Cannibals and garbage piles

21 January 2018

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Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion

21 January 2018

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Transepithelial prion transport by M cells

21 January 2018

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PrP expression in B lymphocytes is not required for prion neuroinvasion

21 January 2018

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21 January 2018

A suspicious signature

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Diagnosis of new variant Creutzfeldt-Jakob disease by tonsil biopsy

21 January 2018

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Altered circadian activity rhythms and sleep in mice devoid of prion protein

21 January 2018

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21 January 2018

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Turning off follicular dendritic cells

21 January 2018

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Monoclonal antibodies inhibit prion replication and delay the development of prion disease

21 January 2018

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BSE transmission to macaques

21 January 2018

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Identification of a protein that purifies with the scrapie prion.

21 January 2018

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Embryonic activation and developmental expression of the murine prion protein gene.

31 March 2020

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Brain copper content and cuproenzyme activity do not vary with prion protein expression level

31 March 2020

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No superoxide dismutase activity of cellular prion protein in vivo.

31 March 2020

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Novel proteinaceous infectious particles cause scrapie

31 March 2020

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Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brain

31 March 2020

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High prion and PrPSc levels but delayed onset of disease in scrapie-inoculated mice heterozygous for a disrupted PrP gene

31 March 2020

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Distribution and accumulation of PrP in gut-associated and peripheral lymphoid tissue of scrapie-affected Suffolk sheep

31 March 2020

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Oral transmission and early lymphoid tropism of chronic wasting disease PrPres in mule deer fawns (Odocoileus hemionus)

31 March 2020

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New Zealand sheep with scrapie-susceptible PrP genotypes succumb to experimental challenge with a sheep-passaged scrapie isolate (SSBP/1)

31 March 2020

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Pathogenesis of Scrapie in the Mouse: the Role of the Spleen

31 March 2020

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Self-replication and scrapie

31 March 2020

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Further Observations on the Experimental Production of Scrapie in Goats and Sheep

31 March 2020

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Distribution of the scrapie agent in the tissues of experimentally inoculated goats

31 March 2020

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Detection of PrPSc in lymphoid tissues of lambs experimentally exposed to the scrapie agent

31 March 2020

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Temporary inactivation of follicular dendritic cells delays neuroinvasion of scrapie

31 March 2020

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Scrapie replication in lymphoid tissues depends on prion protein-expressing follicular dendritic cells

31 March 2020

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Sequential appearance and accumulation of pathognomonic markers in the central nervous system of hamsters orally infected with scrapie

31 March 2020

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Potent inhibition of scrapie-associated PrP accumulation by congo red

31 March 2020

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Amphotericin B delays the incubation period of scrapie in intracerebrally inoculated hamsters.

31 March 2020

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Prophylactic potential of pentosan polysulphate in transmissible spongiform encephalopathies

31 March 2020

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Reversion of prion protein conformational changes by synthetic b-sheet breaker peptides

31 March 2020

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Replication of scrapie in spleens of SCID mice follows reconstitution with wild-type mouse bone marrow

31 March 2020

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Sites of prion protein accumulation in scrapie-infected mouse spleen revealed by immuno-electron microscopy

31 March 2020

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Role of spleen macrophages in the clearance of scrapie agent early in pathogenesis

31 March 2020

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Cross-Linking Cellular Prion Protein Triggers Neuronal Apoptosis in Vivo

31 March 2020

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Manipulation of lymphoid microenvironments in nonhuman primates by an inhibitor of the lymphotoxin pathway

31 March 2020

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Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies

31 March 2020

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New variant of Creutzfeldt-Jakob disease in a 26-year-old French man

31 March 2020

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Virologic and neurohistologic findings in dairy goats affected with natural scrapie

31 March 2020

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Replication of the scrapie agent in ocular neural tissues

31 March 2020

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Spread of scrapie to sheep and goats by oral dosing with foetal membranes from scrapie-affected sheep

31 March 2020

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Infection as the Etiology of Spongiform Encephalopathy (Creutzfeldt-Jakob Disease)

31 March 2020

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Experimental transmission of human subacute spongiform encephalopathy to small rodents. IV. Positive transmission from a typical case of Gerstmann-Sträussler-Scheinker's disease

31 March 2020

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Spongiform encephalopathy transmitted experimentally from Creutzfeldt-Jakob and familial Gerstmann-Sträussler-Scheinker diseases.

31 March 2020

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Strain characterization of natural sheep scrapie and comparison with BSE

31 March 2020

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Early detection of PrPres in BSE-infected bovine PrP transgenic mice.

31 March 2020

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Transmission of bovine spongiform encephalopathy and scrapie to mice: strain variation and the species barrier

31 March 2020

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Identification of two biologically distinct strains of transmissible mink encephalopathy in hamsters.

31 March 2020

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Humoral immune response to native eukaryotic prion protein correlates with anti-prion protection.

31 March 2020

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Abnormal isoform of prion protein accumulates in follicular dendritic cells in mice with Creutzfeldt-Jakob disease

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Scrapie pathogenesis in subclinically infected B-cell-deficient mice

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI1437

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10 August 2017

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PubMed ID

15343371