What can the HLA transgenic mouse tell us about autoimmune diabetes? (Q35878811)

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1 January 2020

review article

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title

What can the HLA transgenic mouse tell us about autoimmune diabetes? (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15349728%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

1

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1 January 2020

author name string

L Wen

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15349728%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

publication date

2 September 2004

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1 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15349728%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

volume

47

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15349728%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

issue

9

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15349728%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

page(s)

1476-1487

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https://scigraph.springernature.com/pub.10.1007/s00125-004-1505-5

1 January 2020

exact match

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cites work

Type 1 diabetes-predisposing MHC alleles influence the selection of glutamic acid decarboxylase (GAD) 65-specific T cells in a transgenic model.

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Epitope-enhanced conserved HIV-1 peptide protects HLA-A2-transgenic mice against virus expressing HIV-1 antigen

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H-2 class I knockout, HLA-A2.1-transgenic mice: a versatile animal model for preclinical evaluation of antitumor immunotherapeutic strategies

21 January 2018

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12 December 2020

T cell epitopes of insulin defined in HLA-DR4 transgenic mice are derived from preproinsulin and proinsulin

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12 December 2020

Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes

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12 December 2020

HLA and Insulin-Dependent Diabetes. A protective perspective

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12 December 2020

Immunotherapy of the nonobese diabetic mouse: treatment with an antibody to T-helper lymphocytes

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12 December 2020

Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice

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12 December 2020

HLA-DR and HLA-DQ polymorphism in human thyroglobulin-induced autoimmune thyroiditis: DR3 and DQ8 transgenic mice are susceptible

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12 December 2020

Immunopathogenesis of collagen arthritis.

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12 December 2020

Novel breast-tumor-associated MUC1-derived peptides: characterization in Db-/- x beta2 microglobulin (beta2m) null mice transgenic for a chimeric HLA-A2.1/Db-beta2 microglobulin single chain

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12 December 2020

Spontaneous inflammatory disease in HLA-B27 transgenic mice is independent of MHC class II molecules: a direct role for B27 heavy chains and not B27-derived peptides

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12 December 2020

Age-dependent HLA genetic heterogeneity of type 1 insulin-dependent diabetes mellitus

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12 December 2020

Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice

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12 December 2020

Optimization and immune recognition of multiple novel conserved HLA-A2, human immunodeficiency virus type 1-specific CTL epitopes

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12 December 2020

Association of the AChRα-subunit Gene (CHRNA), DQA1*0101, and the DR3 Haplotype in Myasthenia Gravis. Evidence for a Three-gene Disease Model in a Subgroup of Patients

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12 December 2020

Recombinant TCR ligand induces tolerance to myelin oligodendrocyte glycoprotein 35-55 peptide and reverses clinical and histological signs of chronic experimental autoimmune encephalomyelitis in HLA-DR2 transgenic mice.

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12 December 2020

Generation of humanized mice susceptible to peptide-induced inflammatory heart disease

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12 December 2020

Modulation of insulitis and type 1 diabetes by transgenic HLA-DR3 and DQ8 in NOD mice lacking endogenous MHC class II.

1 reference

12 December 2020

Incidence of childhood type 1 diabetes worldwide. Diabetes Mondiale (DiaMond) Project Group

1 reference

12 December 2020

Mapping myasthenia gravis-associated T cell epitopes on human acetylcholine receptors in HLA transgenic mice

1 reference

12 December 2020

Worldwide increase in incidence of Type I diabetes--the analysis of the data on published incidence trends

1 reference

12 December 2020

Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes

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12 December 2020

HLA-DQ beta-chain polymorphism linked to myasthenia gravis

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12 December 2020

NOD background genes influence T cell responses to GAD 65 in HLA-DQ8 transgenic mice

1 reference

12 December 2020

The regulatory role of DR4 in a spontaneous diabetes DQ8 transgenic model

1 reference

12 December 2020

HLA class II transgenic mice: models of the human CD4+ T-cell immune response.

1 reference

12 December 2020

The role of CD4 vs. CD8 T cells in IDDM.

1 reference

12 December 2020

Human MHC class I transgenic mice deficient for H2 class I expression facilitate identification and characterization of new HLA class I-restricted viral T cell epitopes

1 reference

12 December 2020

Cross-reactive rubella virus and glutamic acid decarboxylase (65 and 67) protein determinants recognised by T cells of patients with type I diabetes mellitus

1 reference

12 December 2020

DNA immunization with hepatitis C virus (HCV) polycistronic genes or immunization by HCV DNA priming-recombinant canarypox virus boosting induces immune responses and protection from recombinant HCV-vaccinia virus infection in HLA-A2.1-transgenic mi

1 reference

12 December 2020

Major histocompatibility complex class I-deficient NOD-B2mnull mice are diabetes and insulitis resistant

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12 December 2020

Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401.

1 reference

12 December 2020

Identification of HLA-class-II-restricted epitopes of autoantigens in transgenic mice

1 reference

12 December 2020

Identification of autoantigen epitopes in MHC class II transgenic mice.

1 reference

12 December 2020

The T cell response of HLA-DR transgenic mice to human myelin basic protein and other antigens in the presence and absence of human CD4.

1 reference

12 December 2020

ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules

1 reference

12 December 2020

Tolerance to islet antigens and prevention from diabetes induced by limited apoptosis of pancreatic beta cells

1 reference

12 December 2020

Different HLA DR-DQ associations in subgroups of idiopathic myasthenia gravis

1 reference

12 December 2020

CD4+ and CD8+ T-cell clones from congenital rubella syndrome patients with IDDM recognize overlapping GAD65 protein epitopes

1 reference

12 December 2020

HLA associations in type 1 diabetes: merging genetics and immunology

1 reference

12 December 2020

Islet-infiltrating lymphocytes from prediabetic NOD mice rapidly transfer diabetes to NOD-scid/scid mice

1 reference

12 December 2020

Functional interaction between human histocompatibility leukocyte antigen (HLA) class II and mouse CD4 molecule in antigen recognition by T cells in HLA-DR and DQ transgenic mice.

1 reference

12 December 2020

Molecular mimicry in type 1 diabetes mellitus revisited: T-cell clones to GAD65 peptides with sequence homology to Coxsackie or proinsulin peptides do not crossreact with homologous counterpart

1 reference

12 December 2020

Glutamic acid decarboxylase T lymphocyte responses associated with susceptibility or resistance to type I diabetes: analysis in disease discordant human twins, non-obese diabetic mice and HLA-DQ transgenic mice

1 reference

12 December 2020

Induction of type I diabetes by interferon-alpha in transgenic mice

1 reference

12 December 2020

HLA antigens and age at diagnosis of insulin-dependent diabetes mellitus

1 reference

12 December 2020

Optimized autoantibody-based risk assessment in family members. Implications for future intervention trials

1 reference

12 December 2020

Transcomplementation of HLA genes in IDDM. HLA-DQ alpha- and beta-chains produce hybrid molecules in DR3/4 heterozygotes

1 reference

12 December 2020

Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients

1 reference

12 December 2020

The HLA class I A locus affects susceptibility to type 1 diabetes

1 reference

12 December 2020

Molecular properties of HLA-DQ alleles conferring susceptibility to or protection from insulin-dependent diabetes mellitus: keys to the fate of islet beta-cells

1 reference

12 December 2020

Coexpression of susceptible and resistant HLA class II transgenes in murine experimental autoimmune thyroiditis: DQ8 molecules downregulate DR3-mediated thyroiditis.

1 reference

12 December 2020

Binding of conserved islet peptides by human and murine MHC class II molecules associated with susceptibility to type I diabetes

1 reference

12 December 2020

Major DQ8-restricted T-cell epitopes for human GAD65 mapped using human CD4, DQA1*0301, DQB1*0302 transgenic IA(null) NOD mice

1 reference

12 December 2020

Pancreatic expression of B7 co-stimulatory molecules in the non-obese diabetic mouse

1 reference

12 December 2020

Mice lacking MHC class II molecules

1 reference

12 December 2020

The NOD mouse model of type 1 diabetes: as good as it gets?

1 reference

12 December 2020

The role of CD8+ T cells in the initiation of insulin-dependent diabetes mellitus

1 reference

12 December 2020

Effects of the second HLA-DQ haplotype on the association with childhood insulin-dependent diabetes mellitus

1 reference

12 December 2020

In vivo evidence for the contribution of human histocompatibility leukocyte antigen (HLA)-DQ molecules to the development of diabetes

1 reference

12 December 2020

T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes

1 reference

12 December 2020

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

1 reference

12 December 2020

Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase-like protein (phogrin) related to IA-2.

1 reference

12 December 2020

Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice

1 reference

12 December 2020

Correlations between the incidence of childhood-onset type I diabetes in Europe and HLA genotypes

1 reference

12 December 2020

Characterization of self-glutamic acid decarboxylase 65-reactive CD4+ T-cell clones established from Japanese patients with insulin-dependent diabetes mellitus

1 reference

12 December 2020

Autoimmune diabetes in HLA-DR3/DQ8 transgenic mice expressing the co-stimulatory molecule B7-1 in the beta cells of islets of Langerhans

1 reference

12 December 2020

Induction of insulitis by glutamic acid decarboxylase peptide-specific and HLA-DQ8-restricted CD4(+) T cells from human DQ transgenic mice

1 reference

12 December 2020

Transgenic mouse models of rheumatoid arthritis

1 reference

12 December 2020

A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor

1 reference

12 December 2020

Comparative vaccine studies in HLA-A2.1-transgenic mice reveal a clustered organization of epitopes presented in hepatitis C virus natural infection

1 reference

12 December 2020

HLA-DR binding analysis of peptides from islet antigens in IDDM

1 reference

12 December 2020

Islet abnormalities in the pathogenesis of autoimmune diabetes.

1 reference

12 December 2020

Twin-to-twin pancreas transplantation: reversal and reenactment of the pathogenesis of type I diabetes

1 reference

12 December 2020

HLA-DQ-restricted, islet-specific T-cell clones of a type I diabetic patient. T-cell receptor sequence similarities to insulitis-inducing T-cells of nonobese diabetic mice

1 reference

12 December 2020

Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4.

1 reference

12 December 2020

HLA-DQB1 polymorphism determines incidence, onset, and severity of collagen-induced arthritis in transgenic mice. Implications in human rheumatoid arthritis

1 reference

12 December 2020

Functional evidence for the mediation of diabetogenic T cell responses by HLA-A2.1 MHC class I molecules through transgenic expression in NOD mice

1 reference

12 December 2020

HLA-encoded genetic predisposition in IDDM: DR4 subtypes may be associated with different degrees of protection

1 reference

12 December 2020

HLA-DQ8 transgenic and NOD mice recognize different epitopes within the cytoplasmic region of the tyrosine phosphatase-like molecule, IA-2.

1 reference

12 December 2020

HLA-DR modulates autoantibody repertoire, but not mortality, in a humanized mouse model of systemic lupus erythematosus

1 reference

12 December 2020

Insulin Antibodies in Insulin-Dependent Diabetics Before Insulin Treatment

1 reference

12 December 2020

Co-expression of HLA DR3 and DQ8 results in the development of spontaneous insulitis and loss of tolerance to GAD65 in transgenic mice

1 reference

12 December 2020

In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis

1 reference

12 December 2020

A genome-wide search for human type 1 diabetes susceptibility genes

1 reference

12 December 2020

Autoimmune cardiomyopathy and heart block develop spontaneously in HLA-DQ8 transgenic IAbeta knockout NOD mice

1 reference

12 December 2020

Pancreatic infiltration but not diabetes occurs in the relative absence of MHC class II-restricted CD4 T cells: studies using NOD/CIITA-deficient mice

1 reference

12 December 2020

A humanized model of experimental autoimmune uveitis in HLA class II transgenic mice

1 reference

12 December 2020

T cell recognition of human pre-proinsulin peptides depends on the polymorphism at HLA DQ locus: a study using HLA DQ8 and DQ6 transgenic mice

1 reference

12 December 2020

Modelling of the MHC II allele I-A(g7) of NOD mouse: pH-dependent changes in specificity at pockets 9 and 6 explain several of the unique properties of this molecule

1 reference

12 December 2020

Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families

1 reference

12 December 2020

Neonatal injection of CD3 antibody into nonobese diabetic mice reduces the incidence of insulitis and diabetes

1 reference

12 December 2020

Identification of susceptibility loci for insulin-dependent diabetes mellitus by trans-racial gene mapping.

1 reference

12 December 2020

T cell clones to epitopes of glutamic acid decarboxylase 65 raised from normal subjects and patients with insulin-dependent diabetes

1 reference

12 December 2020

Cloned T cells from a recent onset IDDM patient reactive with insulin B-chain.

1 reference

12 December 2020

Genetic control of autoimmune diabetes in the NOD mouse

1 reference

12 December 2020

Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(alpha1*0101,beta1*0401) transgenic mice.

1 reference

12 December 2020

Animal models of the spondyloarthropathies

1 reference

12 December 2020

Determination of glutamic acid decarboxylase 65 peptides presented by the type I diabetes-associated HLA-DQ8 class II molecule identifies an immunogenic peptide motif

1 reference

12 December 2020

A gene in the HLA class I region contributes to susceptibility to IDDM in the Finnish population. Childhood Diabetes in Finland (DiMe) Study Group

1 reference

12 December 2020