Variants on the promoter region of PTEN affect breast cancer progression and patient survival (Q35889659)

10 August 2017

Variants on the promoter region of PTEN affect breast cancer progression and patient survival (English)

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10 August 2017

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10 August 2017

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10 August 2017

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Kristiina Aittomäki

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Liisa Pelttari

Liisa M Pelttari

3

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Tuomas Heikkinen

Tuomas Heikkinen

1

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Dario Greco

Dario Greco

2

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Carl Blomqvist

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Carl Blomqvist

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10 August 2017

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Päivi Heikkilä

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10 August 2017

5

Pia Vahteristo

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10 August 2017

15 December 2011

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10 August 2017

Breast Cancer Research

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10 August 2017

13

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10 August 2017

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10 August 2017

R130

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https://scigraph.springernature.com/pub.10.1186/bcr3076

10 August 2017

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cites work

PTEN level in tumor suppression: how much is too little?

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Subtle variations in Pten dose determine cancer susceptibility

11 July 2018

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Effect of BRCA1/2 mutation on short-term and long-term breast cancer survival: a systematic review and meta-analysis

11 July 2018

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Combined effects of single nucleotide polymorphisms TP53 R72P and MDM2 SNP309, and p53 expression on survival of breast cancer patients

11 July 2018

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PI3K pathway activation in breast cancer is associated with the basal-like phenotype and cancer-specific mortality

11 July 2018

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A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential

11 July 2018

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BAMBI gene is epigenetically silenced in subset of high-grade bladder cancer

11 July 2018

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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

11 July 2018

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The origins of breast cancer prognostic gene expression profiles

11 July 2018

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Tenets of PTEN tumor suppression

11 July 2018

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Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair.

11 July 2018

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Cowden syndrome-affected patients with PTEN promoter mutations demonstrate abnormal protein translation

11 July 2018

1 reference

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Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity.

11 July 2018

1 reference

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Ras, PI(3)K and mTOR signalling controls tumour cell growth

11 July 2018

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Reliability and reproducibility issues in DNA microarray measurements

11 July 2018

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Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts

11 July 2018

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Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer

11 July 2018

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Histopathological features of breast tumours in BRCA1, BRCA2 and mutation-negative breast cancer families

11 July 2018

1 reference

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Bioconductor: open software development for computational biology and bioinformatics

11 July 2018

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Germline PTEN promoter mutations and deletions in Cowden/Bannayan-Riley-Ruvalcaba syndrome result in aberrant PTEN protein and dysregulation of the phosphoinositol-3-kinase/Akt pathway

11 July 2018

1 reference

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A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

11 July 2018

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Regulation of PTEN transcription by p53

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3326572

A probability model for predicting BRCA1 and BRCA2 mutations in breast and breast-ovarian cancer families

11 July 2018

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Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3326572

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3326572

Polymorphisms in PTEN in breast cancer families

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3326572

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3326572

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3326572

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3326572

Identification of the breast cancer susceptibility gene BRCA2

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3326572

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3326572

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3326572

Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3326572

The breast cancer susceptibility mutation PALB2 1592delT is associated with an aggressive tumor phenotype

11 July 2018

1 reference

Breast cancer patients with p53 Pro72 homozygous genotype have a poorer survival

21 January 2018

1 reference

Common genetic variation at PTEN and risk of sporadic breast and prostate cancer

21 January 2018

1 reference

Loss of expression of the PTEN gene protein product is associated with poor outcome in breast cancer

21 January 2018

1 reference

Reduced expression of PTEN correlates with breast cancer progression

21 January 2018

1 reference

PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer

21 January 2018

1 reference

Correlation of CHEK2 protein expression and c.1100delC mutation status with tumor characteristics among unselected breast cancer patients

21 January 2018

1 reference

NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer

21 January 2018

1 reference

The DNA damage signalling kinase ATM is aberrantly reduced or lost in BRCA1/BRCA2-deficient and ER/PR/ERBB2-triple-negative breast cancer

21 January 2018

1 reference

Genetic reclassification of histologic grade delineates new clinical subtypes of breast cancer.

21 January 2018

1 reference

Population-Based Study of BRCA1 and BRCA2 Mutations in 1035 Unselected Finnish Breast Cancer Patients

21 January 2018

1 reference

Ki67 and cyclin A as prognostic factors in early breast cancer. What are the optimal cut-off values?

21 January 2018

1 reference

Localization of the gene for Cowden disease to chromosome 10q22–23

21 January 2018

1 reference

Constipation, polyps, or cancer? let PTEN predict your future

21 January 2018

1 reference

12 December 2020

Reduced expression of PTEN protein and its prognostic implications in invasive ductal carcinoma of the breast

1 reference

12 December 2020

Promoter analysis of tumor suppressor gene PTEN: identification of minimum promoter region

1 reference

12 December 2020

Germline mutations in the breast cancer susceptibility gene PTEN are rare in high-risk non-BRCA1/2 French Canadian breast cancer families

1 reference

12 December 2020

Identifiers

DOI

10.1186/BCR3076

1 reference

PMC publication ID

3326572

Dimensions Publication ID

10 August 2017

0 references

1 reference

PMC publication ID

3326572

10 August 2017

PubMed publication ID

22171747

1 reference

PMC publication ID

3326572