Ras, PI(3)K and mTOR signalling controls tumour cell growth (Q29614734)

Europe PubMed Central

title

Ras, PI(3)K and mTOR signalling controls tumour cell growth (English)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16724053

30 April 2017

author name string

Shaw RJ

series ordinal

1

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30 April 2017

Cantley LC

series ordinal

2

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16724053

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16724053

30 April 2017

language of work or name

1 reference

30 April 2017

publication date

25 May 2006

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16724053

30 April 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16724053

30 April 2017

volume

441

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30 April 2017

page(s)

424-30

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16724053

30 April 2017

issue

7092

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Signalling networks that cause cancer

30 April 2017

cites work

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Targeting the PI3K-Akt pathway in human cancer: rationale and promise

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Oncogenic PI3K deregulates transcription and translation

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7 January 2021

TOR signaling in growth and metabolism

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7 January 2021

Guilty as charged: B-RAF is a human oncogene

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7 January 2021

Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization

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7 January 2021

Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate

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7 January 2021

NF1 tumor suppressor gene function: narrowing the GAP

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7 January 2021

A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity

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7 January 2021

RAS is regulated by the let-7 microRNA family

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7 January 2021

High frequency of mutations of the PIK3CA gene in human cancers

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7 January 2021

Mutant PIK3CA promotes cell growth and invasion of human cancer cells

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7 January 2021

Colorectal cancer: mutations in a signalling pathway

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7 January 2021

The TCL1 family of oncoproteins: co-activators of transformation

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7 January 2021

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

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7 January 2021

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

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7 January 2021

PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

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7 January 2021

Mechanisms of tumor suppression by the SCF(Fbw7).

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7 January 2021

Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage

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7 January 2021

PTEN gene targeting reveals a radiation-induced size checkpoint in human cancer cells

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7 January 2021

Lack of PTEN sequesters CHK1 and initiates genetic instability.

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7 January 2021

The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network

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7 January 2021

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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7 January 2021

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

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7 January 2021

FoxOs at the crossroads of cellular metabolism, differentiation, and transformation

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7 January 2021

Common mechanism for oncogenic activation of MLL by forkhead family proteins

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7 January 2021

United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling

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7 January 2021

Beginnings of a signal-transduction pathway for bioenergetic control of cell survival

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7 January 2021

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

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7 January 2021

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

1 reference

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7 January 2021

mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes

1 reference

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7 January 2021

TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium

1 reference

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7 January 2021

Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors.

1 reference

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7 January 2021

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

1 reference

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7 January 2021

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04869

7 January 2021

The NF1 tumor suppressor critically regulates TSC2 and mTOR.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04869

7 January 2021

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

1 reference

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7 January 2021

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

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7 January 2021

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

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7 January 2021

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

1 reference

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7 January 2021

New roles for the LKB1-->AMPK pathway.

1 reference

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7 January 2021

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

1 reference

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7 January 2021

The LKB1 tumor suppressor negatively regulates mTOR signaling

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7 January 2021

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

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7 January 2021

TSC2 mediates cellular energy response to control cell growth and survival

1 reference

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7 January 2021

Hypoxia-induced energy stress regulates mRNA translation and cell growth

1 reference

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7 January 2021

Regulation of Raf-1 by direct feedback phosphorylation.

1 reference

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7 January 2021

A conditional feedback loop regulates Ras activity through EphA2.

1 reference

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7 January 2021

Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

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7 January 2021

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

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7 January 2021

Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling

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7 January 2021

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

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7 January 2021

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

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7 January 2021

Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2

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7 January 2021

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

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7 January 2021

The Akt-mTOR tango and its relevance to cancer

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7 January 2021

Handicapping the race to develop inhibitors of the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway

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7 January 2021

Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04869

7 January 2021

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04869

7 January 2021

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04869

7 January 2021

ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04869

7 January 2021

Crosstalk between Pten and Ras signaling pathways in tumor development.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04869

7 January 2021

BRAF alterations are associated with complex mutational profiles in malignant melanoma.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04869

7 January 2021

Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04869

7 January 2021

The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04869

7 January 2021

Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04869

7 January 2021

ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04869

7 January 2021

Ras effectors: buying shares in Ras plc.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04869

7 January 2021

Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04869

7 January 2021

RalGDS is required for tumor formation in a model of skin carcinogenesis.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04869

7 January 2021

Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04869

7 January 2021

Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04869

7 January 2021

The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04869

7 January 2021

Rheb binds and regulates the mTOR kinase

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04869

7 January 2021

The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04869

7 January 2021

Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04869

7 January 2021

Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04869

7 January 2021

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04869

7 January 2021

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04869

7 January 2021

Upstream and downstream of mTOR

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04869

7 January 2021

Role of VHL gene mutation in human cancer

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04869

7 January 2021

Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04869

7 January 2021

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16724053

Identifiers

2 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

561326

1031370745

0 references

561326

1 reference

Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16724053

2 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017