A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines. (Q35889665)

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scientific article published on 16 December 2011

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English	A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines.	scientific article published on 16 December 2011

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18 January 2020

A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines (English)

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18 January 2020

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18 January 2020

Silvia Ortega-Gutiérrez

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18 January 2020

Bellinda Benhamú

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18 January 2020

María L López-Rodríguez

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18 January 2020

Ander Urruticoechea

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18 January 2020

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18 January 2020

Helena Aguilar Ribeiro

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Helena Aguilar

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18 January 2020

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Carlos Turrado

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18 January 2020

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Sílvia Cufí

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18 January 2020

Glòria Oliveras

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18 January 2020

publication date

16 December 2011

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18 January 2020

Breast Cancer Research

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18 January 2020

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18 January 2020

6

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18 January 2020

R131

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18 January 2020

Epigallocatechin-3-gallate (EGCG) downregulates gelatinase-B (MMP-9) by involvement of FAK/ERK/NFkappaB and AP-1 in the human breast cancer cell line MDA-MB-231.

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11 July 2018

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p63 promotes cell survival through fatty acid synthase

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11 July 2018

Interaction between fatty acid synthase- and ErbB-systems in ovarian cancer cells

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11 July 2018

Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer

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11 July 2018

Green tea catechin inhibits fatty acid synthase without stimulating carnitine palmitoyltransferase-1 or inducing weight loss in experimental animals.

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Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235.

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EGCG inhibits mammary cancer cell migration through inhibition of nitric oxide synthase and guanylate cyclase

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11 July 2018

Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells

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Pharmacological stimulation of brain carnitine palmitoyl-transferase-1 decreases food intake and body weight

1 reference

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11 July 2018

Trastuzumab-resistant HER2-driven breast cancer cells are sensitive to epigallocatechin-3 gallate

1 reference

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11 July 2018

Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells.

1 reference

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11 July 2018

A novel prodrug of the green tea polyphenol (-)-epigallocatechin-3-gallate as a potential anticancer agent

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11 July 2018

Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer.

1 reference

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11 July 2018

Lapatinib induces apoptosis in trastuzumab-resistant breast cancer cells: effects on insulin-like growth factor I signaling.

1 reference

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11 July 2018

Erlotinib directly inhibits HER2 kinase activation and downstream signaling events in intact cells lacking epidermal growth factor receptor expression

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11 July 2018

Modulation of lipid rafts by Omega-3 fatty acids in inflammation and cancer: implications for use of lipids during nutrition support

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11 July 2018

CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis

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Ras, PI(3)K and mTOR signalling controls tumour cell growth

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11 July 2018

Targeting fatty acid synthase: potential for therapeutic intervention in her-2/neu-overexpressing breast cancer

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RNA interference-mediated silencing of the acetyl-CoA-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells

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(-)-Epigallocatechin gallate and polyphenon E inhibit growth and activation of the epidermal growth factor receptor and human epidermal growth factor receptor-2 signaling pathways in human colon cancer cells

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Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells.

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Novel signaling molecules implicated in tumor-associated fatty acid synthase-dependent breast cancer cell proliferation and survival: Role of exogenous dietary fatty acids, p53-p21WAF1/CIP1, ERK1/2 MAPK, p27KIP1, BRCA1, and NF-kappaB.

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12 December 2020

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18 January 2020

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18 January 2020

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18 January 2020

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