The ATPase activity of MLH1 is required to orchestrate DNA double-strand breaks and end processing during class switch recombination (Q35894189)

11 August 2017

The ATPase activity of MLH1 is required to orchestrate DNA double-strand breaks and end processing during class switch recombination (English)

1 reference

11 August 2017

Richard Chahwan

1

0 references

Sergio Roa

object named as

Sergio Roa

7

0 references

Matthew D Scharff

6

object named as

Matthew D Scharff

1 reference

11 August 2017

Johanna M M van Oers

2

1 reference

11 August 2017

Elena Avdievich

3

1 reference

11 August 2017

Chunfang Zhao

4

1 reference

11 August 2017

Winfried Edelmann

5

1 reference

11 August 2017

language of work or name

English

0 references

publication date

26 March 2012

1 reference

Journal of Experimental Medicine

11 August 2017

1 reference

11 August 2017

209

1 reference

11 August 2017

4

1 reference

11 August 2017

671-678

1 reference

Mismatch-mediated error prone repair at the immunoglobulin genes

11 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

Complex regulation and function of activation-induced cytidine deaminase

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

Mismatch repair proteins MSH2, MLH1, and EXO1 are important for class-switch recombination events occurring in B cells that lack nonhomologous end joining

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

Mapping of switch recombination junctions, a tool for studying DNA repair pathways during immunoglobulin class switching

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

Conservation of functional asymmetry in the mammalian MutLα ATPase

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

Structure of the endonuclease domain of MutL: unlicensed to cut.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

MSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sites

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

Defective mismatch repair, microsatellite mutation bias, and variability in clinical cancer phenotypes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

Functions of MutLalpha, replication protein A (RPA), and HMGB1 in 5'-directed mismatch repair

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

H3 trimethyl K9 and H3 acetyl K9 chromatin modifications are associated with class switch recombination

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

Mechanism of somatic hypermutation: critical analysis of strand biased mutation signatures at A:T and G:C base pairs

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

Non-homologous end joining in class switch recombination: the beginning of the end

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

SHMTool: a webserver for comparative analysis of somatic hypermutation datasets

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

Human PMS2 deficiency is associated with impaired immunoglobulin class switch recombination

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

Distinct effects of the recurrent Mlh1G67R mutation on MMR functions, cancer, and meiosis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

Direct visualization of asymmetric adenine-nucleotide-induced conformational changes in MutL alpha

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

IgH class switching and translocations use a robust non-classical end-joining pathway

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

DNA mismatch repair: functions and mechanisms

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

Monovalent cation dependence and preference of GHKL ATPases and kinases

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

Contribution of human mlh1 and pms2 ATPase activities to DNA mismatch repair

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

GHKL, an emergent ATPase/kinase superfamily

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

Megabase chromatin domains involved in DNA double-strand breaks in vivo

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

Transformation of MutL by ATP binding and hydrolysis: a switch in DNA mismatch repair

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

Hypermutation in Ig V genes from mice deficient in the MLH1 mismatch repair protein

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

An atypical topoisomerase II from Archaea with implications for meiotic recombination

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

Meiotic pachytene arrest in MLH1-deficient mice

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328365

The multifaceted mismatch-repair system

27 July 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20111531

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20111531

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20111531

MutL: conducting the cell's response to mismatched and misaligned DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20111531

Mutations within the hMLH1 and hPMS2 subunits of the human MutLalpha mismatch repair factor affect its ATPase activity, but not its ability to interact with hMutSalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20111531

Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20111531

PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20111531

Functional Significance and Clinical Phenotype of Nontruncating Mismatch Repair Variants of MLH1

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22451719

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The MutL ATPase is required for mismatch repair

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22451719

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1084/JEM.20111531

1 reference

11 August 2017

1 reference

11 August 2017

PubMed publication ID

22451719

1 reference